Nitric oxide metabolism in Neisseria meningitidis
Nitric oxide metabolism in Neisseria meningitidis
Neisseria meningitidis, the causative agent of meningococcal disease in humans, is likely to be exposed to nitrosative stress during natural colonization and disease. The genome of N. meningitidis includes the genes aniA and norB, predicted to encode nitrite reductase and nitric oxide (NO) reductase, respectively. These gene products should allow the bacterium to denitrify nitrite to nitrous oxide. We show that N. meningitidis can support growth microaerobically by the denitrification of nitrite via NO and that norB is required for anaerobic growth with nitrite. NorB and, to a lesser extent, the cycP gene product cytochrome c' are able to counteract toxicity due to exogenously added NO. Expression of these genes by N. meningitidis during colonization and disease may confer protection against exogenous or endogenous nitrosative stress.
Aerobiosis, Cytochrome c Group, Neisseria meningitidis, Nitric Oxide, Nitrites, Oxidoreductases, Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
2987-93
Anjum, Muna F
67131223-aacc-4994-a435-baf5ebfb0d95
Stevanin, Tânia M
ff5fc52c-a001-42d6-9b01-3cb24e4758b1
Read, Robert C
b5caca7b-0063-438a-b703-7ecbb6fc2b51
Moir, James W B
f6831b5f-5cfd-4c56-b3cd-6782f413a07f
June 2002
Anjum, Muna F
67131223-aacc-4994-a435-baf5ebfb0d95
Stevanin, Tânia M
ff5fc52c-a001-42d6-9b01-3cb24e4758b1
Read, Robert C
b5caca7b-0063-438a-b703-7ecbb6fc2b51
Moir, James W B
f6831b5f-5cfd-4c56-b3cd-6782f413a07f
Anjum, Muna F, Stevanin, Tânia M, Read, Robert C and Moir, James W B
(2002)
Nitric oxide metabolism in Neisseria meningitidis.
Journal of Bacteriology, 184 (11), .
(doi:10.1128/JB.184.11.2987-2993.2002).
Abstract
Neisseria meningitidis, the causative agent of meningococcal disease in humans, is likely to be exposed to nitrosative stress during natural colonization and disease. The genome of N. meningitidis includes the genes aniA and norB, predicted to encode nitrite reductase and nitric oxide (NO) reductase, respectively. These gene products should allow the bacterium to denitrify nitrite to nitrous oxide. We show that N. meningitidis can support growth microaerobically by the denitrification of nitrite via NO and that norB is required for anaerobic growth with nitrite. NorB and, to a lesser extent, the cycP gene product cytochrome c' are able to counteract toxicity due to exogenously added NO. Expression of these genes by N. meningitidis during colonization and disease may confer protection against exogenous or endogenous nitrosative stress.
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Published date: June 2002
Keywords:
Aerobiosis, Cytochrome c Group, Neisseria meningitidis, Nitric Oxide, Nitrites, Oxidoreductases, Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
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Local EPrints ID: 416551
URI: http://eprints.soton.ac.uk/id/eprint/416551
ISSN: 0021-9193
PURE UUID: 42d81986-b652-482f-8419-2f75b30b4009
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Date deposited: 21 Dec 2017 17:30
Last modified: 16 Mar 2024 04:10
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Author:
Muna F Anjum
Author:
Tânia M Stevanin
Author:
James W B Moir
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