The University of Southampton
University of Southampton Institutional Repository

Nitric oxide metabolism in Neisseria meningitidis

Nitric oxide metabolism in Neisseria meningitidis
Nitric oxide metabolism in Neisseria meningitidis

Neisseria meningitidis, the causative agent of meningococcal disease in humans, is likely to be exposed to nitrosative stress during natural colonization and disease. The genome of N. meningitidis includes the genes aniA and norB, predicted to encode nitrite reductase and nitric oxide (NO) reductase, respectively. These gene products should allow the bacterium to denitrify nitrite to nitrous oxide. We show that N. meningitidis can support growth microaerobically by the denitrification of nitrite via NO and that norB is required for anaerobic growth with nitrite. NorB and, to a lesser extent, the cycP gene product cytochrome c' are able to counteract toxicity due to exogenously added NO. Expression of these genes by N. meningitidis during colonization and disease may confer protection against exogenous or endogenous nitrosative stress.

Aerobiosis, Cytochrome c Group, Neisseria meningitidis, Nitric Oxide, Nitrites, Oxidoreductases, Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
0021-9193
2987-93
Anjum, Muna F
67131223-aacc-4994-a435-baf5ebfb0d95
Stevanin, Tânia M
ff5fc52c-a001-42d6-9b01-3cb24e4758b1
Read, Robert C
b5caca7b-0063-438a-b703-7ecbb6fc2b51
Moir, James W B
f6831b5f-5cfd-4c56-b3cd-6782f413a07f
Anjum, Muna F
67131223-aacc-4994-a435-baf5ebfb0d95
Stevanin, Tânia M
ff5fc52c-a001-42d6-9b01-3cb24e4758b1
Read, Robert C
b5caca7b-0063-438a-b703-7ecbb6fc2b51
Moir, James W B
f6831b5f-5cfd-4c56-b3cd-6782f413a07f

Anjum, Muna F, Stevanin, Tânia M, Read, Robert C and Moir, James W B (2002) Nitric oxide metabolism in Neisseria meningitidis. Journal of Bacteriology, 184 (11), 2987-93. (doi:10.1128/JB.184.11.2987-2993.2002).

Record type: Article

Abstract

Neisseria meningitidis, the causative agent of meningococcal disease in humans, is likely to be exposed to nitrosative stress during natural colonization and disease. The genome of N. meningitidis includes the genes aniA and norB, predicted to encode nitrite reductase and nitric oxide (NO) reductase, respectively. These gene products should allow the bacterium to denitrify nitrite to nitrous oxide. We show that N. meningitidis can support growth microaerobically by the denitrification of nitrite via NO and that norB is required for anaerobic growth with nitrite. NorB and, to a lesser extent, the cycP gene product cytochrome c' are able to counteract toxicity due to exogenously added NO. Expression of these genes by N. meningitidis during colonization and disease may confer protection against exogenous or endogenous nitrosative stress.

Full text not available from this repository.

More information

Published date: June 2002
Keywords: Aerobiosis, Cytochrome c Group, Neisseria meningitidis, Nitric Oxide, Nitrites, Oxidoreductases, Comparative Study, Journal Article, Research Support, Non-U.S. Gov't

Identifiers

Local EPrints ID: 416551
URI: http://eprints.soton.ac.uk/id/eprint/416551
ISSN: 0021-9193
PURE UUID: 42d81986-b652-482f-8419-2f75b30b4009
ORCID for Robert C Read: ORCID iD orcid.org/0000-0002-4297-6728

Catalogue record

Date deposited: 21 Dec 2017 17:30
Last modified: 18 Feb 2021 17:18

Export record

Altmetrics

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×