The epigenetic clock and objectively measured sedentary and walking behavior in older adults: The Lothian Birth Cohort 1936
The epigenetic clock and objectively measured sedentary and walking behavior in older adults: The Lothian Birth Cohort 1936
Background: Estimates of biological age derived from DNA-methylation patterns-known as the epigenetic clock-are associated with mortality, physical and cognitive function, and frailty, but little is known about their relationship with sedentary behavior or physical activity. We investigated the cross-sectional relationship between two such estimates of biological age and objectively measured sedentary and walking behavior in older people. Methods: Participants were 248 members of the Lothian Birth Cohort 1936. At age 79 years, sedentary behavior and physical activity were measured over 7 days using an activPAL activity monitor. Biological age was estimated using two measures of DNA methylation-based age acceleration-i.e., extrinsic and intrinsic epigenetic age acceleration. We used linear regression to assess the relationship between these two estimates of biological age and average daily time spent sedentary, number of sit-to-stand transitions, and step count. Results: Of the six associations examined, only two were statistically significant in initial models adjusted for age and sex alone. Greater extrinsic age acceleration was associated with taking fewer steps (regression coefficient (95% CI) - 0.100 (- 0.008, - 0.001), and greater intrinsic age acceleration was associated with making more sit-to-stand transitions (regression coefficient (95% CI) 0.006 (0.0001, 0.012). When we controlled for multiple statistical testing, neither of these associations survived correction (both P ≥ 0.17). Conclusion: In this cross-sectional study of 79-year-olds, we found no convincing evidence that biological age, as indexed by extrinsic or intrinsic epigenetic age acceleration, was associated with objectively measured sedentary or walking behavior.
Gale, Catharine
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Marioni, Riccardo E.
dd8c1d6f-c3ed-464a-8c41-50bc9b1a0aad
Čukić, Iva
de28d29b-4254-4620-b5c3-46c9ec4e6045
Chastin, Sebastien F.
61122a84-b8e1-4bda-81c9-1af440179a49
Dall, Philippa
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Dontje, Manon
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Skelton, Dawn A.
531ca71e-d164-4257-94d1-38c57d4887a4
Deary, Ian J.
027158ae-fbfb-40ea-98b1-32d2690499ac
study on behalf of the Seniors USP Team
Gale, Catharine
5bb2abb3-7b53-42d6-8aa7-817e193140c8
Marioni, Riccardo E.
dd8c1d6f-c3ed-464a-8c41-50bc9b1a0aad
Čukić, Iva
de28d29b-4254-4620-b5c3-46c9ec4e6045
Chastin, Sebastien F.
61122a84-b8e1-4bda-81c9-1af440179a49
Dall, Philippa
0ef4b0dd-a29a-425c-906a-44d638ee6668
Dontje, Manon
9e40ca02-1844-479e-8caf-e24e63d704cb
Skelton, Dawn A.
531ca71e-d164-4257-94d1-38c57d4887a4
Deary, Ian J.
027158ae-fbfb-40ea-98b1-32d2690499ac
Gale, Catharine, Marioni, Riccardo E., Čukić, Iva, Chastin, Sebastien F., Dall, Philippa, Dontje, Manon, Skelton, Dawn A. and Deary, Ian J.
,
study on behalf of the Seniors USP Team
(2018)
The epigenetic clock and objectively measured sedentary and walking behavior in older adults: The Lothian Birth Cohort 1936.
Clinical Epigenetics, 10 (1), [4].
(doi:10.1186/s13148-017-0438-z).
Abstract
Background: Estimates of biological age derived from DNA-methylation patterns-known as the epigenetic clock-are associated with mortality, physical and cognitive function, and frailty, but little is known about their relationship with sedentary behavior or physical activity. We investigated the cross-sectional relationship between two such estimates of biological age and objectively measured sedentary and walking behavior in older people. Methods: Participants were 248 members of the Lothian Birth Cohort 1936. At age 79 years, sedentary behavior and physical activity were measured over 7 days using an activPAL activity monitor. Biological age was estimated using two measures of DNA methylation-based age acceleration-i.e., extrinsic and intrinsic epigenetic age acceleration. We used linear regression to assess the relationship between these two estimates of biological age and average daily time spent sedentary, number of sit-to-stand transitions, and step count. Results: Of the six associations examined, only two were statistically significant in initial models adjusted for age and sex alone. Greater extrinsic age acceleration was associated with taking fewer steps (regression coefficient (95% CI) - 0.100 (- 0.008, - 0.001), and greater intrinsic age acceleration was associated with making more sit-to-stand transitions (regression coefficient (95% CI) 0.006 (0.0001, 0.012). When we controlled for multiple statistical testing, neither of these associations survived correction (both P ≥ 0.17). Conclusion: In this cross-sectional study of 79-year-olds, we found no convincing evidence that biological age, as indexed by extrinsic or intrinsic epigenetic age acceleration, was associated with objectively measured sedentary or walking behavior.
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Accepted/In Press date: 21 December 2017
e-pub ahead of print date: 8 January 2018
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Local EPrints ID: 416612
URI: http://eprints.soton.ac.uk/id/eprint/416612
ISSN: 1868-7075
PURE UUID: 17d025d1-0fe4-4214-ab91-242589e3cc48
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Date deposited: 03 Jan 2018 17:30
Last modified: 16 Mar 2024 06:02
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Author:
Riccardo E. Marioni
Author:
Iva Čukić
Author:
Sebastien F. Chastin
Author:
Philippa Dall
Author:
Manon Dontje
Author:
Dawn A. Skelton
Author:
Ian J. Deary
Corporate Author: study on behalf of the Seniors USP Team
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