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The epigenetic clock and objectively measured sedentary and walking behavior in older adults: The Lothian Birth Cohort 1936

The epigenetic clock and objectively measured sedentary and walking behavior in older adults: The Lothian Birth Cohort 1936
The epigenetic clock and objectively measured sedentary and walking behavior in older adults: The Lothian Birth Cohort 1936

Background: Estimates of biological age derived from DNA-methylation patterns-known as the epigenetic clock-are associated with mortality, physical and cognitive function, and frailty, but little is known about their relationship with sedentary behavior or physical activity. We investigated the cross-sectional relationship between two such estimates of biological age and objectively measured sedentary and walking behavior in older people. Methods: Participants were 248 members of the Lothian Birth Cohort 1936. At age 79 years, sedentary behavior and physical activity were measured over 7 days using an activPAL activity monitor. Biological age was estimated using two measures of DNA methylation-based age acceleration-i.e., extrinsic and intrinsic epigenetic age acceleration. We used linear regression to assess the relationship between these two estimates of biological age and average daily time spent sedentary, number of sit-to-stand transitions, and step count. Results: Of the six associations examined, only two were statistically significant in initial models adjusted for age and sex alone. Greater extrinsic age acceleration was associated with taking fewer steps (regression coefficient (95% CI) - 0.100 (- 0.008, - 0.001), and greater intrinsic age acceleration was associated with making more sit-to-stand transitions (regression coefficient (95% CI) 0.006 (0.0001, 0.012). When we controlled for multiple statistical testing, neither of these associations survived correction (both P ≥ 0.17). Conclusion: In this cross-sectional study of 79-year-olds, we found no convincing evidence that biological age, as indexed by extrinsic or intrinsic epigenetic age acceleration, was associated with objectively measured sedentary or walking behavior.

1868-7075
Gale, Catharine
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Marioni, Riccardo E.
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Čukić, Iva
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Chastin, Sebastien F.
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Dall, Philippa
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Dontje, Manon
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Skelton, Dawn A.
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Deary, Ian J.
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Cox, Simon
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Coulter, Elaine
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Cukic, Iva
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Dall, Philippa
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Deary, Ian
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Der, Geoff
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Dontje, Manon
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Fitzsimons, Claire
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Gill, Jason
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Granat, Malcolm
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Gray, Cindy
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Greig, Carolyn
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Hindle, Elaine
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Laird, Karen
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Mead, Gillian
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Mutrie, Nanette
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Palmer, Victoria
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Radakovic, Ratko
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Sattar, Naveed
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Shaw, Richard
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Starr, John
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Stewart, Sally
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Wyke, Sally
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study on behalf of the Seniors USP Team
Gale, Catharine
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Marioni, Riccardo E.
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Čukić, Iva
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Chastin, Sebastien F.
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Dall, Philippa
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Dontje, Manon
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Skelton, Dawn A.
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Deary, Ian J.
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Cox, Simon
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Coulter, Elaine
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Cukic, Iva
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Dall, Philippa
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Deary, Ian
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Der, Geoff
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Dontje, Manon
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Fitzsimons, Claire
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Gill, Jason
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Granat, Malcolm
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Gray, Cindy
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Greig, Carolyn
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Hindle, Elaine
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Laird, Karen
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Mead, Gillian
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Mutrie, Nanette
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Palmer, Victoria
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Radakovic, Ratko
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Sattar, Naveed
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Shaw, Richard
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Starr, John
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Stewart, Sally
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Wyke, Sally
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Gale, Catharine, Marioni, Riccardo E., Čukić, Iva, Chastin, Sebastien F., Dall, Philippa, Dontje, Manon, Skelton, Dawn A., Deary, Ian J., Cox, Simon, Coulter, Elaine, Cukic, Iva, Dall, Philippa, Deary, Ian, Der, Geoff, Dontje, Manon, Fitzsimons, Claire, Gill, Jason, Granat, Malcolm, Gray, Cindy, Greig, Carolyn, Hindle, Elaine, Laird, Karen, Mead, Gillian, Mutrie, Nanette, Palmer, Victoria, Radakovic, Ratko, Sattar, Naveed, Shaw, Richard, Starr, John, Stewart, Sally and Wyke, Sally , study on behalf of the Seniors USP Team (2018) The epigenetic clock and objectively measured sedentary and walking behavior in older adults: The Lothian Birth Cohort 1936. Clinical Epigenetics, 10 (1). (doi:10.1186/s13148-017-0438-z).

Record type: Article

Abstract

Background: Estimates of biological age derived from DNA-methylation patterns-known as the epigenetic clock-are associated with mortality, physical and cognitive function, and frailty, but little is known about their relationship with sedentary behavior or physical activity. We investigated the cross-sectional relationship between two such estimates of biological age and objectively measured sedentary and walking behavior in older people. Methods: Participants were 248 members of the Lothian Birth Cohort 1936. At age 79 years, sedentary behavior and physical activity were measured over 7 days using an activPAL activity monitor. Biological age was estimated using two measures of DNA methylation-based age acceleration-i.e., extrinsic and intrinsic epigenetic age acceleration. We used linear regression to assess the relationship between these two estimates of biological age and average daily time spent sedentary, number of sit-to-stand transitions, and step count. Results: Of the six associations examined, only two were statistically significant in initial models adjusted for age and sex alone. Greater extrinsic age acceleration was associated with taking fewer steps (regression coefficient (95% CI) - 0.100 (- 0.008, - 0.001), and greater intrinsic age acceleration was associated with making more sit-to-stand transitions (regression coefficient (95% CI) 0.006 (0.0001, 0.012). When we controlled for multiple statistical testing, neither of these associations survived correction (both P ≥ 0.17). Conclusion: In this cross-sectional study of 79-year-olds, we found no convincing evidence that biological age, as indexed by extrinsic or intrinsic epigenetic age acceleration, was associated with objectively measured sedentary or walking behavior.

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Accepted/In Press date: 21 December 2017
e-pub ahead of print date: 8 January 2018

Identifiers

Local EPrints ID: 416612
URI: https://eprints.soton.ac.uk/id/eprint/416612
ISSN: 1868-7075
PURE UUID: 17d025d1-0fe4-4214-ab91-242589e3cc48

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Date deposited: 03 Jan 2018 17:30
Last modified: 18 Mar 2018 05:01

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Contributors

Author: Catharine Gale
Author: Riccardo E. Marioni
Author: Iva Čukić
Author: Sebastien F. Chastin
Author: Philippa Dall
Author: Manon Dontje
Author: Dawn A. Skelton
Author: Ian J. Deary
Author: Simon Cox
Author: Elaine Coulter
Author: Iva Cukic
Author: Philippa Dall
Author: Ian Deary
Author: Geoff Der
Author: Manon Dontje
Author: Claire Fitzsimons
Author: Jason Gill
Author: Malcolm Granat
Author: Cindy Gray
Author: Carolyn Greig
Author: Elaine Hindle
Author: Karen Laird
Author: Gillian Mead
Author: Nanette Mutrie
Author: Victoria Palmer
Author: Ratko Radakovic
Author: Naveed Sattar
Author: Richard Shaw
Author: John Starr
Author: Sally Stewart
Author: Sally Wyke

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