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Opsonic phagocytosis of Streptococcus pneumoniae by alveolar macrophages is not impaired in human immunodeficiency virus-infected Malawian adults

Opsonic phagocytosis of Streptococcus pneumoniae by alveolar macrophages is not impaired in human immunodeficiency virus-infected Malawian adults
Opsonic phagocytosis of Streptococcus pneumoniae by alveolar macrophages is not impaired in human immunodeficiency virus-infected Malawian adults

Streptococcus pneumoniae is a major cause of pneumonia, bacteremia, and meningitis, especially among adults infected with the human immunodeficiency virus (HIV). Alveolar macrophages (AMs) are critical components of cellular defense against bacterial infection and are both infected and affected by HIV. In this study, AMs obtained at bronchoscopy from 44 Malawian adults (24 HIV positive and 20 HIV negative) were exposed in vitro to opsonized S. pneumoniae and coagulase-negative staphylococci. AMs from HIV-positive and -negative volunteers showed no significant difference in binding to or internalization of either S. pneumoniae or coagulase-negative staphylococci. In HIV-positive subjects, the presence of detectable HIV in lung fluid was not associated with AM impairment. AMs from HIV-infected adults did not exhibit impaired pneumococcal phagocytosis in the assay used. This suggests that an alternative mechanism of susceptibility is operating in these individuals.

Adult, Coagulase, Female, HIV Infections, Humans, Macrophages, Alveolar, Malawi, Male, Opsonin Proteins, Phagocytosis, Staphylococcus, Streptococcus pneumoniae, Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
0022-1899
1345-1349
Gordon, Stephen B.
d004fb35-bf59-4028-a55f-56eb478706a2
Molyneux, Malcolm E.
2da5a12a-1c16-49bc-9b13-c068029e9676
Boeree, Martin J.
a467db34-05ec-4b20-b97a-5cc990aa142c
Kanyanda, Stonard
c6e306c0-22ef-445c-a286-e11b6e90dcd9
Chaponda, Mas
1e8c8667-8bce-4816-b7ee-edebc02dfb7d
Squire, S. Bertel
8bc79e0a-59dc-4d89-b5c2-580bc38f2d31
Read, Robert C.
b5caca7b-0063-438a-b703-7ecbb6fc2b51
Gordon, Stephen B.
d004fb35-bf59-4028-a55f-56eb478706a2
Molyneux, Malcolm E.
2da5a12a-1c16-49bc-9b13-c068029e9676
Boeree, Martin J.
a467db34-05ec-4b20-b97a-5cc990aa142c
Kanyanda, Stonard
c6e306c0-22ef-445c-a286-e11b6e90dcd9
Chaponda, Mas
1e8c8667-8bce-4816-b7ee-edebc02dfb7d
Squire, S. Bertel
8bc79e0a-59dc-4d89-b5c2-580bc38f2d31
Read, Robert C.
b5caca7b-0063-438a-b703-7ecbb6fc2b51

Gordon, Stephen B., Molyneux, Malcolm E., Boeree, Martin J., Kanyanda, Stonard, Chaponda, Mas, Squire, S. Bertel and Read, Robert C. (2001) Opsonic phagocytosis of Streptococcus pneumoniae by alveolar macrophages is not impaired in human immunodeficiency virus-infected Malawian adults. The Journal of Infectious Diseases, 184 (10), 1345-1349. (doi:10.1086/324080).

Record type: Article

Abstract

Streptococcus pneumoniae is a major cause of pneumonia, bacteremia, and meningitis, especially among adults infected with the human immunodeficiency virus (HIV). Alveolar macrophages (AMs) are critical components of cellular defense against bacterial infection and are both infected and affected by HIV. In this study, AMs obtained at bronchoscopy from 44 Malawian adults (24 HIV positive and 20 HIV negative) were exposed in vitro to opsonized S. pneumoniae and coagulase-negative staphylococci. AMs from HIV-positive and -negative volunteers showed no significant difference in binding to or internalization of either S. pneumoniae or coagulase-negative staphylococci. In HIV-positive subjects, the presence of detectable HIV in lung fluid was not associated with AM impairment. AMs from HIV-infected adults did not exhibit impaired pneumococcal phagocytosis in the assay used. This suggests that an alternative mechanism of susceptibility is operating in these individuals.

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More information

Published date: 15 November 2001
Keywords: Adult, Coagulase, Female, HIV Infections, Humans, Macrophages, Alveolar, Malawi, Male, Opsonin Proteins, Phagocytosis, Staphylococcus, Streptococcus pneumoniae, Comparative Study, Journal Article, Research Support, Non-U.S. Gov't

Identifiers

Local EPrints ID: 416634
URI: https://eprints.soton.ac.uk/id/eprint/416634
ISSN: 0022-1899
PURE UUID: 45067a05-c181-4635-b1e6-32ad0e08d285
ORCID for Robert C. Read: ORCID iD orcid.org/0000-0002-4297-6728

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Date deposited: 03 Jan 2018 17:31
Last modified: 20 Jul 2019 00:42

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Contributors

Author: Stephen B. Gordon
Author: Malcolm E. Molyneux
Author: Martin J. Boeree
Author: Stonard Kanyanda
Author: Mas Chaponda
Author: S. Bertel Squire
Author: Robert C. Read ORCID iD

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