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New revelations from an old receptor: Immunoregulatory functions of the inhibitory Fc gamma receptor, FcγRIIB (CD32B)

New revelations from an old receptor: Immunoregulatory functions of the inhibitory Fc gamma receptor, FcγRIIB (CD32B)
New revelations from an old receptor: Immunoregulatory functions of the inhibitory Fc gamma receptor, FcγRIIB (CD32B)
The Fc gamma receptor IIB (FcγRIIB/CD32B), was generated million years ago during evolution. It is the sole inhibitory receptor for immunoglobulin (Ig) G, and has long been associated with the regulation of humoral immunity and innate immune homeostasis. However, new and surprising functions of FcγRIIB are emerging. In particular, FcγRIIB has been shown to perform unexpected activatory roles in both immune-signaling and monoclonal antibody (mAb) immunotherapy. Furthermore, although immunoreceptor tyrosine-based inhibitory motif (ITIM) signaling is an integral part of FcγRIIB regulatory activity, it is now clear that inhibition/activation of immune responses can occur independently of the ITIM. In light of these new findings, we present an overview of the established and non-canonical functions of FcγRIIB and discuss how this knowledge might be exploited therapeutically.
0741-5400
Roghanian, Ali
e2b032c2-60a0-4522-a3d8-56a768792f36
Stopforth, Richard J.
2d3e18ff-5563-4247-9150-f0f337fb585f
Dahal, Lekh N.
1e993a7a-b007-4187-82ea-e28dd3920b66
Cragg, Mark S.
ec97f80e-f3c8-49b7-a960-20dff648b78c
Roghanian, Ali
e2b032c2-60a0-4522-a3d8-56a768792f36
Stopforth, Richard J.
2d3e18ff-5563-4247-9150-f0f337fb585f
Dahal, Lekh N.
1e993a7a-b007-4187-82ea-e28dd3920b66
Cragg, Mark S.
ec97f80e-f3c8-49b7-a960-20dff648b78c

Roghanian, Ali, Stopforth, Richard J., Dahal, Lekh N. and Cragg, Mark S. (2018) New revelations from an old receptor: Immunoregulatory functions of the inhibitory Fc gamma receptor, FcγRIIB (CD32B). Journal of Leukocyte Biology. (doi:10.1002/JLB.2MIR0917-354R).

Record type: Article

Abstract

The Fc gamma receptor IIB (FcγRIIB/CD32B), was generated million years ago during evolution. It is the sole inhibitory receptor for immunoglobulin (Ig) G, and has long been associated with the regulation of humoral immunity and innate immune homeostasis. However, new and surprising functions of FcγRIIB are emerging. In particular, FcγRIIB has been shown to perform unexpected activatory roles in both immune-signaling and monoclonal antibody (mAb) immunotherapy. Furthermore, although immunoreceptor tyrosine-based inhibitory motif (ITIM) signaling is an integral part of FcγRIIB regulatory activity, it is now clear that inhibition/activation of immune responses can occur independently of the ITIM. In light of these new findings, we present an overview of the established and non-canonical functions of FcγRIIB and discuss how this knowledge might be exploited therapeutically.

Text
Roghanian et al. JLB FcγRIIB mini-review (Oct 17) - Accepted Manuscript
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More information

Accepted/In Press date: 15 December 2017
e-pub ahead of print date: 6 February 2018

Identifiers

Local EPrints ID: 416675
URI: https://eprints.soton.ac.uk/id/eprint/416675
ISSN: 0741-5400
PURE UUID: c1aaed43-ff4f-4677-a7af-250bc38d8249
ORCID for Mark S. Cragg: ORCID iD orcid.org/0000-0003-2077-089X

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Date deposited: 04 Jan 2018 17:30
Last modified: 14 Mar 2019 05:21

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