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Expression of PI3K signaling associated with T cells in psoriasis is inhibited by seletalisib, a PI3Kδ inhibitor, and is required for functional activity

Expression of PI3K signaling associated with T cells in psoriasis is inhibited by seletalisib, a PI3Kδ inhibitor, and is required for functional activity
Expression of PI3K signaling associated with T cells in psoriasis is inhibited by seletalisib, a PI3Kδ inhibitor, and is required for functional activity
The phosphoinositide 3-kinase (PI3K) pathway plays a key role in many cellular processes, including cell proliferation, survival, and protein synthesis, with the PI3K isoform, PI3Kδ, involved in normal T-cell development and function (Jarmin et al., 2008, Lucas et al., 2016, Vanhaesebroeck et al., 2012). Evidence to suggest that PI3K signaling might play a role in psoriasis comes from reports of increased expression of phosphorylated protein kinase B, mammalian target of rapamycin, and ribosomal protein S6 (pS6), which are downstream in the PI3K signaling pathway, in lesional psoriatic skin compared with nonlesional skin and healthy controls (Buerger et al., 2013, Madonna et al., 2012, Rosenberger et al., 2007). In addition, PI3Kδ knock-in mice, expressing a catalytically inactive form of PI3Kδ (p110δD910A/D910A), and PI3Kγ knockout mice are greatly protected from imiquimod-induced psoriasis-like skin inflammation compared with wild-type mice (Roller et al., 2012).
0022-202X
1-4
Yager, Nicole
079005d5-296c-4f62-a71f-2cd14d04b43a
Haddadeen, Ciara
8f6d1127-c1fb-478a-bd3f-5ca002d7f268
Powell, Mark
bb9e9071-11b3-468a-8776-fc8556b32b81
Payne, Andrew
b158f374-d4ff-460d-ade6-f411ac487ab7
Allen, Rodger
61c5e0a7-c0e3-4a16-a338-f4b35a55815f
Healy, Eugene
400fc04d-f81a-474a-ae25-7ff894be0ebd
Yager, Nicole
079005d5-296c-4f62-a71f-2cd14d04b43a
Haddadeen, Ciara
8f6d1127-c1fb-478a-bd3f-5ca002d7f268
Powell, Mark
bb9e9071-11b3-468a-8776-fc8556b32b81
Payne, Andrew
b158f374-d4ff-460d-ade6-f411ac487ab7
Allen, Rodger
61c5e0a7-c0e3-4a16-a338-f4b35a55815f
Healy, Eugene
400fc04d-f81a-474a-ae25-7ff894be0ebd

Yager, Nicole, Haddadeen, Ciara, Powell, Mark, Payne, Andrew, Allen, Rodger and Healy, Eugene (2018) Expression of PI3K signaling associated with T cells in psoriasis is inhibited by seletalisib, a PI3Kδ inhibitor, and is required for functional activity. Journal of Investigative Dermatology, 1-4. (doi:10.1016/j.jid.2017.12.028).

Record type: Article

Abstract

The phosphoinositide 3-kinase (PI3K) pathway plays a key role in many cellular processes, including cell proliferation, survival, and protein synthesis, with the PI3K isoform, PI3Kδ, involved in normal T-cell development and function (Jarmin et al., 2008, Lucas et al., 2016, Vanhaesebroeck et al., 2012). Evidence to suggest that PI3K signaling might play a role in psoriasis comes from reports of increased expression of phosphorylated protein kinase B, mammalian target of rapamycin, and ribosomal protein S6 (pS6), which are downstream in the PI3K signaling pathway, in lesional psoriatic skin compared with nonlesional skin and healthy controls (Buerger et al., 2013, Madonna et al., 2012, Rosenberger et al., 2007). In addition, PI3Kδ knock-in mice, expressing a catalytically inactive form of PI3Kδ (p110δD910A/D910A), and PI3Kγ knockout mice are greatly protected from imiquimod-induced psoriasis-like skin inflammation compared with wild-type mice (Roller et al., 2012).

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Accepted/In Press date: 21 December 2017
e-pub ahead of print date: 5 January 2018

Identifiers

Local EPrints ID: 416786
URI: https://eprints.soton.ac.uk/id/eprint/416786
ISSN: 0022-202X
PURE UUID: 4abce21d-b6d4-42e6-b070-faa343ab700b

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Date deposited: 10 Jan 2018 17:30
Last modified: 15 Aug 2019 04:27

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