Mannose-binding lectin regulates the inflammatory response of human professional phagocytes to Neisseria meningitidis serogroup B
Mannose-binding lectin regulates the inflammatory response of human professional phagocytes to Neisseria meningitidis serogroup B
The influence of the innate immune protein mannose-binding lectin (MBL) on the response of human phagocytes to Neisseria meningitidis was investigated. MBL increased the association of killed meningococci with neutrophils, monocytes, and macrophages by increasing the proportion of cells that recognized bacteria. MBL down-regulated the normal change in expression of the leukocyte adhesion molecules CD11b and CD62L. In an ex vivo model, the addition of MBL to the blood of MBL-deficient donors influenced the production of monocyte-derived inflammatory cytokines. The addition of high concentrations of MBL (>6 microg/mL) profoundly decreased the production of interleukin (IL)-6, IL-1beta, and tumor necrosis factor-alpha by monocytes in response to meningococci, whereas lower concentrations enhanced the production of IL-6 and IL-1beta. These results suggest that MBL not only is involved in complement activation but also is a potent regulator of inflammatory pathways and, as such, may affect the severity of meningococcal disease.
CD11 Antigens, Carrier Proteins, Cytokines, Humans, Inflammation, L-Selectin, Lectins, Mannose-Binding Lectins, Meningitis, Meningococcal, Monocytes, Neisseria meningitidis, Neutrophils, Phagocytes, Phagocytosis, Serotyping, Journal Article, Research Support, Non-U.S. Gov't
1152-1162
Jack, D L
be8b5f4c-b73a-454d-89bf-d5e47c7ac624
Read, R.C.
b5caca7b-0063-438a-b703-7ecbb6fc2b51
Tenner, A.J.
30fb9553-f51c-4523-bf0f-5c79cd6315fd
Frosch, M.
83d0ca82-349b-46a4-8d87-176cafd95945
Turner, M.W.
d4814746-0fcb-40db-8b3e-9dc44986c5af
Klein, N.J.
f01b50e5-cb25-4558-99aa-b697d534fb55
1 November 2001
Jack, D L
be8b5f4c-b73a-454d-89bf-d5e47c7ac624
Read, R.C.
b5caca7b-0063-438a-b703-7ecbb6fc2b51
Tenner, A.J.
30fb9553-f51c-4523-bf0f-5c79cd6315fd
Frosch, M.
83d0ca82-349b-46a4-8d87-176cafd95945
Turner, M.W.
d4814746-0fcb-40db-8b3e-9dc44986c5af
Klein, N.J.
f01b50e5-cb25-4558-99aa-b697d534fb55
Jack, D L, Read, R.C., Tenner, A.J., Frosch, M., Turner, M.W. and Klein, N.J.
(2001)
Mannose-binding lectin regulates the inflammatory response of human professional phagocytes to Neisseria meningitidis serogroup B.
The Journal of Infectious Diseases, 184 (9), .
(doi:10.1086/323803).
Abstract
The influence of the innate immune protein mannose-binding lectin (MBL) on the response of human phagocytes to Neisseria meningitidis was investigated. MBL increased the association of killed meningococci with neutrophils, monocytes, and macrophages by increasing the proportion of cells that recognized bacteria. MBL down-regulated the normal change in expression of the leukocyte adhesion molecules CD11b and CD62L. In an ex vivo model, the addition of MBL to the blood of MBL-deficient donors influenced the production of monocyte-derived inflammatory cytokines. The addition of high concentrations of MBL (>6 microg/mL) profoundly decreased the production of interleukin (IL)-6, IL-1beta, and tumor necrosis factor-alpha by monocytes in response to meningococci, whereas lower concentrations enhanced the production of IL-6 and IL-1beta. These results suggest that MBL not only is involved in complement activation but also is a potent regulator of inflammatory pathways and, as such, may affect the severity of meningococcal disease.
This record has no associated files available for download.
More information
Published date: 1 November 2001
Keywords:
CD11 Antigens, Carrier Proteins, Cytokines, Humans, Inflammation, L-Selectin, Lectins, Mannose-Binding Lectins, Meningitis, Meningococcal, Monocytes, Neisseria meningitidis, Neutrophils, Phagocytes, Phagocytosis, Serotyping, Journal Article, Research Support, Non-U.S. Gov't
Identifiers
Local EPrints ID: 416809
URI: http://eprints.soton.ac.uk/id/eprint/416809
ISSN: 0022-1899
PURE UUID: 9cde47cd-262d-4956-8759-d842a9b37375
Catalogue record
Date deposited: 10 Jan 2018 17:30
Last modified: 16 Mar 2024 04:10
Export record
Altmetrics
Contributors
Author:
D L Jack
Author:
A.J. Tenner
Author:
M. Frosch
Author:
M.W. Turner
Author:
N.J. Klein
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics
