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Mannose-binding lectin regulates the inflammatory response of human professional phagocytes to Neisseria meningitidis serogroup B

Mannose-binding lectin regulates the inflammatory response of human professional phagocytes to Neisseria meningitidis serogroup B
Mannose-binding lectin regulates the inflammatory response of human professional phagocytes to Neisseria meningitidis serogroup B

The influence of the innate immune protein mannose-binding lectin (MBL) on the response of human phagocytes to Neisseria meningitidis was investigated. MBL increased the association of killed meningococci with neutrophils, monocytes, and macrophages by increasing the proportion of cells that recognized bacteria. MBL down-regulated the normal change in expression of the leukocyte adhesion molecules CD11b and CD62L. In an ex vivo model, the addition of MBL to the blood of MBL-deficient donors influenced the production of monocyte-derived inflammatory cytokines. The addition of high concentrations of MBL (>6 microg/mL) profoundly decreased the production of interleukin (IL)-6, IL-1beta, and tumor necrosis factor-alpha by monocytes in response to meningococci, whereas lower concentrations enhanced the production of IL-6 and IL-1beta. These results suggest that MBL not only is involved in complement activation but also is a potent regulator of inflammatory pathways and, as such, may affect the severity of meningococcal disease.

CD11 Antigens, Carrier Proteins, Cytokines, Humans, Inflammation, L-Selectin, Lectins, Mannose-Binding Lectins, Meningitis, Meningococcal, Monocytes, Neisseria meningitidis, Neutrophils, Phagocytes, Phagocytosis, Serotyping, Journal Article, Research Support, Non-U.S. Gov't
0022-1899
1152-1162
Jack, D L
be8b5f4c-b73a-454d-89bf-d5e47c7ac624
Read, R.C.
b5caca7b-0063-438a-b703-7ecbb6fc2b51
Tenner, A.J.
30fb9553-f51c-4523-bf0f-5c79cd6315fd
Frosch, M.
83d0ca82-349b-46a4-8d87-176cafd95945
Turner, M.W.
d4814746-0fcb-40db-8b3e-9dc44986c5af
Klein, N.J.
f01b50e5-cb25-4558-99aa-b697d534fb55
Jack, D L
be8b5f4c-b73a-454d-89bf-d5e47c7ac624
Read, R.C.
b5caca7b-0063-438a-b703-7ecbb6fc2b51
Tenner, A.J.
30fb9553-f51c-4523-bf0f-5c79cd6315fd
Frosch, M.
83d0ca82-349b-46a4-8d87-176cafd95945
Turner, M.W.
d4814746-0fcb-40db-8b3e-9dc44986c5af
Klein, N.J.
f01b50e5-cb25-4558-99aa-b697d534fb55

Jack, D L, Read, R.C., Tenner, A.J., Frosch, M., Turner, M.W. and Klein, N.J. (2001) Mannose-binding lectin regulates the inflammatory response of human professional phagocytes to Neisseria meningitidis serogroup B. The Journal of Infectious Diseases, 184 (9), 1152-1162. (doi:10.1086/323803).

Record type: Article

Abstract

The influence of the innate immune protein mannose-binding lectin (MBL) on the response of human phagocytes to Neisseria meningitidis was investigated. MBL increased the association of killed meningococci with neutrophils, monocytes, and macrophages by increasing the proportion of cells that recognized bacteria. MBL down-regulated the normal change in expression of the leukocyte adhesion molecules CD11b and CD62L. In an ex vivo model, the addition of MBL to the blood of MBL-deficient donors influenced the production of monocyte-derived inflammatory cytokines. The addition of high concentrations of MBL (>6 microg/mL) profoundly decreased the production of interleukin (IL)-6, IL-1beta, and tumor necrosis factor-alpha by monocytes in response to meningococci, whereas lower concentrations enhanced the production of IL-6 and IL-1beta. These results suggest that MBL not only is involved in complement activation but also is a potent regulator of inflammatory pathways and, as such, may affect the severity of meningococcal disease.

Full text not available from this repository.

More information

Published date: 1 November 2001
Keywords: CD11 Antigens, Carrier Proteins, Cytokines, Humans, Inflammation, L-Selectin, Lectins, Mannose-Binding Lectins, Meningitis, Meningococcal, Monocytes, Neisseria meningitidis, Neutrophils, Phagocytes, Phagocytosis, Serotyping, Journal Article, Research Support, Non-U.S. Gov't

Identifiers

Local EPrints ID: 416809
URI: https://eprints.soton.ac.uk/id/eprint/416809
ISSN: 0022-1899
PURE UUID: 9cde47cd-262d-4956-8759-d842a9b37375
ORCID for R.C. Read: ORCID iD orcid.org/0000-0002-4297-6728

Catalogue record

Date deposited: 10 Jan 2018 17:30
Last modified: 14 Mar 2019 01:36

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