The University of Southampton
University of Southampton Institutional Repository

Bacterial meningitis in Malawian adults: pneumococcal disease is common, severe, and seasonal

Bacterial meningitis in Malawian adults: pneumococcal disease is common, severe, and seasonal
Bacterial meningitis in Malawian adults: pneumococcal disease is common, severe, and seasonal

We prospectively collected laboratory details and outcome data on all patients with laboratory-confirmed cases of meningitis that presented to our unit in Blantyre, Malawi, from 1 April 1998 through 31 March 1999. There were 502 patients with cases of meningitis; the most common causative organisms were Cryptococcus neoformans and Streptococcus pneumoniae. This pattern probably reflects the local human immunodeficiency virus (HIV) seroprevalence (31%) and is different from the pattern in 1974, when Neisseria meningitidis was the most common isolate. There has been an 8-fold increase in the number of meningitis cases per year since 1974, and a doubling of the percentage of medical admissions due to meningitis. The inpatient mortality rate among patients with cases of pneumococcal meningitis was 61%, and in the group as a whole was 41%. Despite the HIV-related pattern of infecting pathogens among these cases of meningitis and the increased incidence of the condition, there was evidence that the typical seasonal pattern of pneumococcal meningitis, which peaks in the cold, dry season, was preserved.

Adult, Cryptococcosis, Cryptococcus neoformans, Drug Resistance, Microbial, Female, Humans, Malawi, Male, Meningitis, Bacterial, Meningitis, Meningococcal, Meningitis, Pneumococcal, Neisseria meningitidis, Prospective Studies, Seasons, Journal Article, Research Support, Non-U.S. Gov't
1058-4838
53-57
Gordon, S B
d004fb35-bf59-4028-a55f-56eb478706a2
Walsh, A.L.
3b6caee2-69c5-45d3-9e45-0b7ba6c114ec
Chaponda, M.
1e8c8667-8bce-4816-b7ee-edebc02dfb7d
Gordon, M.A.
d63b6bc8-5b49-4848-9910-35885e6bc563
Soko, D.
1848bc4c-5e15-4712-b412-b2ffb268f1cf
Mbwvinji, M.
f630b7dd-82d7-48cd-a346-8713285bd6f4
Molyneux, M.E.
2da5a12a-1c16-49bc-9b13-c068029e9676
Read, R.C.
b5caca7b-0063-438a-b703-7ecbb6fc2b51
Gordon, S B
d004fb35-bf59-4028-a55f-56eb478706a2
Walsh, A.L.
3b6caee2-69c5-45d3-9e45-0b7ba6c114ec
Chaponda, M.
1e8c8667-8bce-4816-b7ee-edebc02dfb7d
Gordon, M.A.
d63b6bc8-5b49-4848-9910-35885e6bc563
Soko, D.
1848bc4c-5e15-4712-b412-b2ffb268f1cf
Mbwvinji, M.
f630b7dd-82d7-48cd-a346-8713285bd6f4
Molyneux, M.E.
2da5a12a-1c16-49bc-9b13-c068029e9676
Read, R.C.
b5caca7b-0063-438a-b703-7ecbb6fc2b51

Gordon, S B, Walsh, A.L., Chaponda, M., Gordon, M.A., Soko, D., Mbwvinji, M., Molyneux, M.E. and Read, R.C. (2000) Bacterial meningitis in Malawian adults: pneumococcal disease is common, severe, and seasonal. Clinical Infectious Diseases, 31 (1), 53-57. (doi:10.1086/313910).

Record type: Article

Abstract

We prospectively collected laboratory details and outcome data on all patients with laboratory-confirmed cases of meningitis that presented to our unit in Blantyre, Malawi, from 1 April 1998 through 31 March 1999. There were 502 patients with cases of meningitis; the most common causative organisms were Cryptococcus neoformans and Streptococcus pneumoniae. This pattern probably reflects the local human immunodeficiency virus (HIV) seroprevalence (31%) and is different from the pattern in 1974, when Neisseria meningitidis was the most common isolate. There has been an 8-fold increase in the number of meningitis cases per year since 1974, and a doubling of the percentage of medical admissions due to meningitis. The inpatient mortality rate among patients with cases of pneumococcal meningitis was 61%, and in the group as a whole was 41%. Despite the HIV-related pattern of infecting pathogens among these cases of meningitis and the increased incidence of the condition, there was evidence that the typical seasonal pattern of pneumococcal meningitis, which peaks in the cold, dry season, was preserved.

Full text not available from this repository.

More information

Published date: July 2000
Keywords: Adult, Cryptococcosis, Cryptococcus neoformans, Drug Resistance, Microbial, Female, Humans, Malawi, Male, Meningitis, Bacterial, Meningitis, Meningococcal, Meningitis, Pneumococcal, Neisseria meningitidis, Prospective Studies, Seasons, Journal Article, Research Support, Non-U.S. Gov't

Identifiers

Local EPrints ID: 416853
URI: https://eprints.soton.ac.uk/id/eprint/416853
ISSN: 1058-4838
PURE UUID: ff06cfa9-7d2c-4018-8a71-42d3373ebcab
ORCID for R.C. Read: ORCID iD orcid.org/0000-0002-4297-6728

Catalogue record

Date deposited: 11 Jan 2018 17:30
Last modified: 20 Jul 2019 00:42

Export record

Altmetrics

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of https://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×