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Differential recognition of obligate anaerobic bacteria by human mannose-binding lectin

Differential recognition of obligate anaerobic bacteria by human mannose-binding lectin
Differential recognition of obligate anaerobic bacteria by human mannose-binding lectin

Deficiency of the innate, humoral immune component mannose-binding lectin (MBL) predisposes individuals to a variety of infections, but the importance of MBL in infection by anaerobes has not been addressed. The attachment of MBL to a wide range of anaerobic bacteria associated with human disease and colonization was surveyed. The results suggest that for the species we examined, resistance to MBL binding may be associated with organisms that are more commonly pathogenic and that MBL binding to some bacteria may be phase variable.

Bacteria, Anaerobic, Carrier Proteins, Collectins, Galactose, Gram-Negative Bacteria, Gram-Positive Bacteria, Lectins, Mannose, Protein Binding, Journal Article, Research Support, Non-U.S. Gov't
0009-9104
223-228
Townsend, R.
f684df45-51a1-4e43-9033-b74265e22e2a
Read, R.C.
b5caca7b-0063-438a-b703-7ecbb6fc2b51
Turner, M.W.
8a3aa06d-eded-4906-a117-0f6e4887455a
Klein, N.J.
f01b50e5-cb25-4558-99aa-b697d534fb55
Jack, D.L.
91f0e626-c2f4-4de2-bfbe-afd2e9284578
Townsend, R.
f684df45-51a1-4e43-9033-b74265e22e2a
Read, R.C.
b5caca7b-0063-438a-b703-7ecbb6fc2b51
Turner, M.W.
8a3aa06d-eded-4906-a117-0f6e4887455a
Klein, N.J.
f01b50e5-cb25-4558-99aa-b697d534fb55
Jack, D.L.
91f0e626-c2f4-4de2-bfbe-afd2e9284578

Townsend, R., Read, R.C., Turner, M.W., Klein, N.J. and Jack, D.L. (2001) Differential recognition of obligate anaerobic bacteria by human mannose-binding lectin. Clinical and Experimental Immunology, 124 (2), 223-228. (doi:10.1046/j.1365-2249.2001.01549.x).

Record type: Article

Abstract

Deficiency of the innate, humoral immune component mannose-binding lectin (MBL) predisposes individuals to a variety of infections, but the importance of MBL in infection by anaerobes has not been addressed. The attachment of MBL to a wide range of anaerobic bacteria associated with human disease and colonization was surveyed. The results suggest that for the species we examined, resistance to MBL binding may be associated with organisms that are more commonly pathogenic and that MBL binding to some bacteria may be phase variable.

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More information

Accepted/In Press date: 16 February 2001
Published date: May 2001
Keywords: Bacteria, Anaerobic, Carrier Proteins, Collectins, Galactose, Gram-Negative Bacteria, Gram-Positive Bacteria, Lectins, Mannose, Protein Binding, Journal Article, Research Support, Non-U.S. Gov't

Identifiers

Local EPrints ID: 416855
URI: https://eprints.soton.ac.uk/id/eprint/416855
ISSN: 0009-9104
PURE UUID: 9a42dfa6-c04b-4137-8bf0-4aafce9ec9e1
ORCID for R.C. Read: ORCID iD orcid.org/0000-0002-4297-6728

Catalogue record

Date deposited: 11 Jan 2018 17:30
Last modified: 14 Mar 2019 01:36

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Contributors

Author: R. Townsend
Author: R.C. Read ORCID iD
Author: M.W. Turner
Author: N.J. Klein
Author: D.L. Jack

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