Nonalcoholic fatty liver disease in children
Nonalcoholic fatty liver disease in children
Nonalcoholic steatohepatitis, a progressive form of nonalcoholic fatty liver disease (NAFLD), is one of the most common hepatic diseases in children who present with particular risk factors including obesity, sedentary lifestyle, and/or a predisposing genetic background. The worldwide prevalence of NAFLD in children is a worrying phenomenon because this disease is closely associated with the development of both cirrhosis and cardiometabolic syndrome in adulthood. To date, the etiopathogenesis of primary NAFLD in children is unknown. Understanding the pathogenetic mechanisms provides the basis to characterize early predictors of the disease and noninvasive diagnostic tools and to design novel specific treatments and possible management strategies. Despite a few clinical trials on the use of antioxidants combined with lifestyle intervention for NAFLD, no treatment exists for children with NAFLD. In this review, the authors provide an overview of current concepts in epidemiology, histological features, etiopathogenesis, diagnosis, and treatment of NAFLD in pediatric population.
1-13
Mann, Jake
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Valenti, Luca
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Scorletti, Eleonora
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Byrne, Christopher
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Nobili, Valerio
9c3a1aa7-3130-415c-8cec-00ab0e665ab1
February 2018
Mann, Jake
a5c12970-1d2c-4fe6-86ac-5726ff9b28e6
Valenti, Luca
5aa1145d-fc50-4cbe-a054-e0702229553f
Scorletti, Eleonora
42bb0659-ac67-4a73-bf36-a881fe6c1563
Byrne, Christopher
1370b997-cead-4229-83a7-53301ed2a43c
Nobili, Valerio
9c3a1aa7-3130-415c-8cec-00ab0e665ab1
Mann, Jake, Valenti, Luca, Scorletti, Eleonora, Byrne, Christopher and Nobili, Valerio
(2018)
Nonalcoholic fatty liver disease in children.
Seminars in Liver Disease, 38 (01), .
(doi:10.1055/s-0038-1627456).
Abstract
Nonalcoholic steatohepatitis, a progressive form of nonalcoholic fatty liver disease (NAFLD), is one of the most common hepatic diseases in children who present with particular risk factors including obesity, sedentary lifestyle, and/or a predisposing genetic background. The worldwide prevalence of NAFLD in children is a worrying phenomenon because this disease is closely associated with the development of both cirrhosis and cardiometabolic syndrome in adulthood. To date, the etiopathogenesis of primary NAFLD in children is unknown. Understanding the pathogenetic mechanisms provides the basis to characterize early predictors of the disease and noninvasive diagnostic tools and to design novel specific treatments and possible management strategies. Despite a few clinical trials on the use of antioxidants combined with lifestyle intervention for NAFLD, no treatment exists for children with NAFLD. In this review, the authors provide an overview of current concepts in epidemiology, histological features, etiopathogenesis, diagnosis, and treatment of NAFLD in pediatric population.
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Accepted/In Press date: 27 December 2017
e-pub ahead of print date: 22 February 2018
Published date: February 2018
Identifiers
Local EPrints ID: 416882
URI: http://eprints.soton.ac.uk/id/eprint/416882
ISSN: 0272-8087
PURE UUID: db600ef4-200c-407d-b688-b26e9d181248
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Date deposited: 12 Jan 2018 17:30
Last modified: 16 Mar 2024 06:05
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Contributors
Author:
Jake Mann
Author:
Luca Valenti
Author:
Eleonora Scorletti
Author:
Valerio Nobili
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