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Magnetic stimulation in the microscale: the development of a 6x6 array of micro-coils for stimulation of excitable cells in vitro

Magnetic stimulation in the microscale: the development of a 6x6 array of micro-coils for stimulation of excitable cells in vitro
Magnetic stimulation in the microscale: the development of a 6x6 array of micro-coils for stimulation of excitable cells in vitro
In this study we present the development of a prototype device, designed for micro-magnetic stimulation of excitable cells in vitro. Each platform consists of a 6x6 two-dimensional array of micro-coils, in an attempt to achieve highly localised magnetic flux patterns. The coils are fabricated with standard micro-fabrication techniques, including steps of photolithography, dry etching and electroplating. The further interfacing of the micro-magnetic chip into a biocompatible platform is also described. The samples are characterised electrically, while a finite element method simulation study is performed and reveals a 141mV-strong electric potential induced in the vicinity of a micro-coil. Since applications in neuronal cells is our primary focus, modelling with NEURON software is used for demonstrating the capability of the platform to activate adjacent cells. Finally, an experimental validation of the proof of concept is performed with the measurement of induced current into a custom-made phantom gel that shows similar electric properties with brain tissue.
Rizou, Maria-Eleni
3043e5bb-670b-4a38-878b-f0301a65afea
Prodromakis, Themistoklis
d58c9c10-9d25-4d22-b155-06c8437acfbf
Rizou, Maria-Eleni
3043e5bb-670b-4a38-878b-f0301a65afea
Prodromakis, Themistoklis
d58c9c10-9d25-4d22-b155-06c8437acfbf

Rizou, Maria-Eleni and Prodromakis, Themistoklis (2018) Magnetic stimulation in the microscale: the development of a 6x6 array of micro-coils for stimulation of excitable cells in vitro. Biomedical Physics & Engineering Express, 4 (2). (doi:10.1088/2057-1976/aaa0dd).

Record type: Article

Abstract

In this study we present the development of a prototype device, designed for micro-magnetic stimulation of excitable cells in vitro. Each platform consists of a 6x6 two-dimensional array of micro-coils, in an attempt to achieve highly localised magnetic flux patterns. The coils are fabricated with standard micro-fabrication techniques, including steps of photolithography, dry etching and electroplating. The further interfacing of the micro-magnetic chip into a biocompatible platform is also described. The samples are characterised electrically, while a finite element method simulation study is performed and reveals a 141mV-strong electric potential induced in the vicinity of a micro-coil. Since applications in neuronal cells is our primary focus, modelling with NEURON software is used for demonstrating the capability of the platform to activate adjacent cells. Finally, an experimental validation of the proof of concept is performed with the measurement of induced current into a custom-made phantom gel that shows similar electric properties with brain tissue.

Text
Rizou+et+al_2017_Biomed._Phys._Eng._Express_10.1088_2057-1976_aaa0dd - Accepted Manuscript
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Accepted/In Press date: 12 December 2017
e-pub ahead of print date: 22 January 2018
Published date: 22 January 2018

Identifiers

Local EPrints ID: 416908
URI: https://eprints.soton.ac.uk/id/eprint/416908
PURE UUID: 2eb7b4bf-6dbb-46b1-98e0-45c7442fcf24
ORCID for Themistoklis Prodromakis: ORCID iD orcid.org/0000-0002-6267-6909

Catalogue record

Date deposited: 13 Jan 2018 17:30
Last modified: 10 Dec 2019 05:36

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