Response to oral and intravenous azithromycin in a patient with toxoplasma encephalitis and AIDS
Response to oral and intravenous azithromycin in a patient with toxoplasma encephalitis and AIDS
We present a patient with AIDS and toxoplasma encephalitis who was unable to tolerate established therapy with sulphadiazine or clindamycin but responded to oral azithromycin and pyrimethamine. The patient was maintained on oral azithromycin but subsequently relapsed after 8 months. The recurrence was successfully treated with intravenous azithromycin. The case illustrates that azithromycin can be used to treat patients with toxoplasma encephalitis who are unable to tolerate or fail to respond to other therapeutic agents. Failure of oral azithromycin may be due to inadequate tissue concentrations and patients may further benefit from intravenous administration.
AIDS-Related Opportunistic Infections, Administration, Oral, Adult, Anti-Bacterial Agents, Azithromycin, Encephalitis, Humans, Infusions, Intravenous, Male, Toxoplasmosis, Cerebral, Case Reports, Journal Article
227-229
Wiselka, M.J.
c7a9c751-4e85-4e44-aac5-35de2b848383
Read, R.
b5caca7b-0063-438a-b703-7ecbb6fc2b51
Finch, R.G.
6492b427-f814-4123-a753-c20502679abe
November 1996
Wiselka, M.J.
c7a9c751-4e85-4e44-aac5-35de2b848383
Read, R.
b5caca7b-0063-438a-b703-7ecbb6fc2b51
Finch, R.G.
6492b427-f814-4123-a753-c20502679abe
Wiselka, M.J., Read, R. and Finch, R.G.
(1996)
Response to oral and intravenous azithromycin in a patient with toxoplasma encephalitis and AIDS.
Journal of Infection, 33 (3), .
(doi:10.1016/S0163-4453(96)92393-2).
Abstract
We present a patient with AIDS and toxoplasma encephalitis who was unable to tolerate established therapy with sulphadiazine or clindamycin but responded to oral azithromycin and pyrimethamine. The patient was maintained on oral azithromycin but subsequently relapsed after 8 months. The recurrence was successfully treated with intravenous azithromycin. The case illustrates that azithromycin can be used to treat patients with toxoplasma encephalitis who are unable to tolerate or fail to respond to other therapeutic agents. Failure of oral azithromycin may be due to inadequate tissue concentrations and patients may further benefit from intravenous administration.
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Accepted/In Press date: 25 June 1996
Published date: November 1996
Keywords:
AIDS-Related Opportunistic Infections, Administration, Oral, Adult, Anti-Bacterial Agents, Azithromycin, Encephalitis, Humans, Infusions, Intravenous, Male, Toxoplasmosis, Cerebral, Case Reports, Journal Article
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Local EPrints ID: 417035
URI: http://eprints.soton.ac.uk/id/eprint/417035
ISSN: 0163-4453
PURE UUID: babc12a9-3d56-4fca-9079-b0cc1d5c11d4
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Date deposited: 17 Jan 2018 17:30
Last modified: 16 Mar 2024 04:10
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Author:
M.J. Wiselka
Author:
R.G. Finch
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