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Clinical and laboratory findings in the Paul-Bunnell negative glandular fever-fatigue syndrome

Clinical and laboratory findings in the Paul-Bunnell negative glandular fever-fatigue syndrome
Clinical and laboratory findings in the Paul-Bunnell negative glandular fever-fatigue syndrome

Forty-one patients with recurrent fatigue were studied for evidence of symptom clustering, abnormal laboratory findings and infection with novel viruses. Symptom enquiry and investigations were repeated 4 months later. Four patients were found to have diseases compatible with their symptoms. In those remaining, an initial acute onset of symptoms was associated with an intermittent course, tender glands and a raised number of T suppressor lymphocytes. Raised numbers of T suppressor lymphocytes at follow-up correlated with resolution of symptoms. Antibodies to human herpesvirus 6 (HHV-6) were found in 75% of the patients as compared to 53% of a control group and more patients than controls were strongly seropositive. Some patients with chronic fatigue have a pattern of illness which suggests glandular fever, although acute infection with Epstein-Barr virus (EBV) is not demonstrated. Primary or reactivation infection with HHV-6 may have a role in this syndrome.

Adolescent, Adult, Antibodies, Viral, Fatigue Syndrome, Chronic, Female, Herpesvirus 6, Human, Humans, Infectious Mononucleosis, Leukocyte Count, Male, Middle Aged, Recurrence, Referral and Consultation, Surveys and Questionnaires, Time Factors, Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
0163-4453
157-165
Read, R.
b5caca7b-0063-438a-b703-7ecbb6fc2b51
Larson, E.
5be9e286-2431-488c-b97a-1864e0059f88
Harvey, J.
6a62bfca-3d77-4222-a153-6c8f59f33e28
Edwards, A.
59c01056-ed68-421d-9535-a5c77f3dd0ec
Thomson, B.
6edf05f7-484c-438b-a656-51b09aee1e99
Briggs, M.
15503235-9de2-4a2d-a176-47d918b49d7a
Fox, J.
f081df01-d2c6-44e5-89ec-13492947e14a
Read, R.
b5caca7b-0063-438a-b703-7ecbb6fc2b51
Larson, E.
5be9e286-2431-488c-b97a-1864e0059f88
Harvey, J.
6a62bfca-3d77-4222-a153-6c8f59f33e28
Edwards, A.
59c01056-ed68-421d-9535-a5c77f3dd0ec
Thomson, B.
6edf05f7-484c-438b-a656-51b09aee1e99
Briggs, M.
15503235-9de2-4a2d-a176-47d918b49d7a
Fox, J.
f081df01-d2c6-44e5-89ec-13492947e14a

Read, R., Larson, E., Harvey, J., Edwards, A., Thomson, B., Briggs, M. and Fox, J. (1990) Clinical and laboratory findings in the Paul-Bunnell negative glandular fever-fatigue syndrome. Journal of Infection, 21 (2), 157-165. (doi:10.1016/0163-4453(90)91675-4).

Record type: Article

Abstract

Forty-one patients with recurrent fatigue were studied for evidence of symptom clustering, abnormal laboratory findings and infection with novel viruses. Symptom enquiry and investigations were repeated 4 months later. Four patients were found to have diseases compatible with their symptoms. In those remaining, an initial acute onset of symptoms was associated with an intermittent course, tender glands and a raised number of T suppressor lymphocytes. Raised numbers of T suppressor lymphocytes at follow-up correlated with resolution of symptoms. Antibodies to human herpesvirus 6 (HHV-6) were found in 75% of the patients as compared to 53% of a control group and more patients than controls were strongly seropositive. Some patients with chronic fatigue have a pattern of illness which suggests glandular fever, although acute infection with Epstein-Barr virus (EBV) is not demonstrated. Primary or reactivation infection with HHV-6 may have a role in this syndrome.

Full text not available from this repository.

More information

Accepted/In Press date: 13 March 1990
Published date: September 1990
Keywords: Adolescent, Adult, Antibodies, Viral, Fatigue Syndrome, Chronic, Female, Herpesvirus 6, Human, Humans, Infectious Mononucleosis, Leukocyte Count, Male, Middle Aged, Recurrence, Referral and Consultation, Surveys and Questionnaires, Time Factors, Comparative Study, Journal Article, Research Support, Non-U.S. Gov't

Identifiers

Local EPrints ID: 417037
URI: https://eprints.soton.ac.uk/id/eprint/417037
ISSN: 0163-4453
PURE UUID: f293fd42-db0c-43a5-b063-72c071f3e484
ORCID for R. Read: ORCID iD orcid.org/0000-0002-4297-6728

Catalogue record

Date deposited: 17 Jan 2018 17:30
Last modified: 14 Mar 2019 01:36

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