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von Willebrand factor is an acute phase reactant in man

von Willebrand factor is an acute phase reactant in man
von Willebrand factor is an acute phase reactant in man

Plasma von Willebrand factor antigen (vWfAg) concentrations in 19 patients with acute infectious illnesses of bacterial, viral or parasitic origin were significantly elevated with a mean greater than 3-fold above normal. In individual patients the elevation of vWf correlated strongly with the elevation of serum C-reactive protein (CRP). When patients were studied longitudinally, vWfAg and CRP concentrations both returned to normal values over 3-4 weeks. Similarly, in 14 volunteers infected with cold virus, vWfAg and CRP levels rose significantly and fell together during the course of infection. VWf is thus an acute phase reactant in man.

Acute-Phase Proteins, C-Reactive Protein, Humans, Infection, Picornaviridae Infections, Rhinovirus, Time Factors, von Willebrand Factor, Journal Article
0049-3848
387-394
Pottinger, B.E.
9490a98c-52fc-43a6-82c6-227bca4958df
Read, R.C.
b5caca7b-0063-438a-b703-7ecbb6fc2b51
Paleolog, E.M.
d69e2c82-9ea0-42d9-bcd9-6b549da0de2f
Higgins, P.G.
f1bf7f79-9155-484d-b974-9a546b001a3a
Pearson, J.D.
0a9cff41-5f02-4ab0-a00e-c7bf1e3238fa
Pottinger, B.E.
9490a98c-52fc-43a6-82c6-227bca4958df
Read, R.C.
b5caca7b-0063-438a-b703-7ecbb6fc2b51
Paleolog, E.M.
d69e2c82-9ea0-42d9-bcd9-6b549da0de2f
Higgins, P.G.
f1bf7f79-9155-484d-b974-9a546b001a3a
Pearson, J.D.
0a9cff41-5f02-4ab0-a00e-c7bf1e3238fa

Pottinger, B.E., Read, R.C., Paleolog, E.M., Higgins, P.G. and Pearson, J.D. (1989) von Willebrand factor is an acute phase reactant in man. Thrombosis Research, 53 (4), 387-394. (doi:10.1016/0049-3848(89)90317-4).

Record type: Article

Abstract

Plasma von Willebrand factor antigen (vWfAg) concentrations in 19 patients with acute infectious illnesses of bacterial, viral or parasitic origin were significantly elevated with a mean greater than 3-fold above normal. In individual patients the elevation of vWf correlated strongly with the elevation of serum C-reactive protein (CRP). When patients were studied longitudinally, vWfAg and CRP concentrations both returned to normal values over 3-4 weeks. Similarly, in 14 volunteers infected with cold virus, vWfAg and CRP levels rose significantly and fell together during the course of infection. VWf is thus an acute phase reactant in man.

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More information

Accepted/In Press date: 8 December 1988
Published date: 15 February 1989
Keywords: Acute-Phase Proteins, C-Reactive Protein, Humans, Infection, Picornaviridae Infections, Rhinovirus, Time Factors, von Willebrand Factor, Journal Article

Identifiers

Local EPrints ID: 417039
URI: http://eprints.soton.ac.uk/id/eprint/417039
ISSN: 0049-3848
PURE UUID: b7c91dcf-9956-43a4-8375-295f3c241908
ORCID for R.C. Read: ORCID iD orcid.org/0000-0002-4297-6728

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Date deposited: 17 Jan 2018 17:30
Last modified: 18 Feb 2021 17:18

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Contributors

Author: B.E. Pottinger
Author: R.C. Read ORCID iD
Author: E.M. Paleolog
Author: P.G. Higgins
Author: J.D. Pearson

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