von Willebrand factor is an acute phase reactant in man
von Willebrand factor is an acute phase reactant in man
Plasma von Willebrand factor antigen (vWfAg) concentrations in 19 patients with acute infectious illnesses of bacterial, viral or parasitic origin were significantly elevated with a mean greater than 3-fold above normal. In individual patients the elevation of vWf correlated strongly with the elevation of serum C-reactive protein (CRP). When patients were studied longitudinally, vWfAg and CRP concentrations both returned to normal values over 3-4 weeks. Similarly, in 14 volunteers infected with cold virus, vWfAg and CRP levels rose significantly and fell together during the course of infection. VWf is thus an acute phase reactant in man.
Acute-Phase Proteins, C-Reactive Protein, Humans, Infection, Picornaviridae Infections, Rhinovirus, Time Factors, von Willebrand Factor, Journal Article
387-394
Pottinger, B.E.
9490a98c-52fc-43a6-82c6-227bca4958df
Read, R.C.
b5caca7b-0063-438a-b703-7ecbb6fc2b51
Paleolog, E.M.
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Higgins, P.G.
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Pearson, J.D.
0a9cff41-5f02-4ab0-a00e-c7bf1e3238fa
15 February 1989
Pottinger, B.E.
9490a98c-52fc-43a6-82c6-227bca4958df
Read, R.C.
b5caca7b-0063-438a-b703-7ecbb6fc2b51
Paleolog, E.M.
d69e2c82-9ea0-42d9-bcd9-6b549da0de2f
Higgins, P.G.
f1bf7f79-9155-484d-b974-9a546b001a3a
Pearson, J.D.
0a9cff41-5f02-4ab0-a00e-c7bf1e3238fa
Pottinger, B.E., Read, R.C., Paleolog, E.M., Higgins, P.G. and Pearson, J.D.
(1989)
von Willebrand factor is an acute phase reactant in man.
Thrombosis Research, 53 (4), .
(doi:10.1016/0049-3848(89)90317-4).
Abstract
Plasma von Willebrand factor antigen (vWfAg) concentrations in 19 patients with acute infectious illnesses of bacterial, viral or parasitic origin were significantly elevated with a mean greater than 3-fold above normal. In individual patients the elevation of vWf correlated strongly with the elevation of serum C-reactive protein (CRP). When patients were studied longitudinally, vWfAg and CRP concentrations both returned to normal values over 3-4 weeks. Similarly, in 14 volunteers infected with cold virus, vWfAg and CRP levels rose significantly and fell together during the course of infection. VWf is thus an acute phase reactant in man.
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Accepted/In Press date: 8 December 1988
Published date: 15 February 1989
Keywords:
Acute-Phase Proteins, C-Reactive Protein, Humans, Infection, Picornaviridae Infections, Rhinovirus, Time Factors, von Willebrand Factor, Journal Article
Identifiers
Local EPrints ID: 417039
URI: http://eprints.soton.ac.uk/id/eprint/417039
ISSN: 0049-3848
PURE UUID: b7c91dcf-9956-43a4-8375-295f3c241908
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Date deposited: 17 Jan 2018 17:30
Last modified: 16 Mar 2024 04:10
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Contributors
Author:
B.E. Pottinger
Author:
E.M. Paleolog
Author:
P.G. Higgins
Author:
J.D. Pearson
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