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No genetic association between attention-deficit/hyperactivity disorder (ADHD) and Parkinson’s disease in nine ADHD candidate SNPs

No genetic association between attention-deficit/hyperactivity disorder (ADHD) and Parkinson’s disease in nine ADHD candidate SNPs
No genetic association between attention-deficit/hyperactivity disorder (ADHD) and Parkinson’s disease in nine ADHD candidate SNPs

Attention-deficit/hyperactivity disorder (ADHD) and Parkinson’s disease (PD) involve pathological changes in brain structures such as the basal ganglia, which are essential for the control of motor and cognitive behavior and impulsivity. The cause of ADHD and PD remains unknown, but there is increasing evidence that both seem to result from a complicated interplay of genetic and environmental factors affecting numerous cellular processes and brain regions. To explore the possibility of common genetic pathways within the respective pathophysiologies, nine ADHD candidate single nucleotide polymorphisms (SNPs) in seven genes were tested for association with PD in 5333 cases and 12,019 healthy controls: one variant, respectively, in the genes coding for synaptosomal-associated protein 25k (SNAP25), the dopamine (DA) transporter (SLC6A3; DAT1), DA receptor D4 (DRD4), serotonin receptor 1B (HTR1B), tryptophan hydroxylase 2 (TPH2), the norepinephrine transporter SLC6A2 and three SNPs in cadherin 13 (CDH13). Information was extracted from a recent meta-analysis of five genome-wide association studies, in which 7,689,524 SNPs in European samples were successfully imputed. No significant association was observed after correction for multiple testing. Therefore, it is reasonable to conclude that candidate variants implicated in the pathogenesis of ADHD do not play a substantial role in PD.

ADHD, CDH13, Dopamine transporter, GWAS, Parkinson’s disease, SNPs
1866-6116
121-127
Geissler, Julia M.
f8c28768-add1-4ec4-92b5-519bd112d628
Burn, David J.
c03da9e0-b16c-4304-b236-3395dbbe7840
Harris, Clare
ad7c242c-7033-46b4-afd3-398b98f24d85
Morrison, Karen E.
f00890f0-2fde-4dbd-a73b-7422e1b0ede8
Walker, Robert
c8fbfe1c-349d-497f-b24e-0295c84c4634
Romanos, Marcel
5c528f4e-c368-4ad3-956a-02ab952eac73
Gerlach, Manfred
a2eba42f-727a-4120-a774-9d30b2c23813
Berg, Daniela
8c642343-acb1-4b23-aa50-4f3eb5785399
Schulte, Claudia
835f596e-3ee2-4e3c-8b8a-30608c059d48
International Parkinson Disease Genomics Consortium members
Geissler, Julia M.
f8c28768-add1-4ec4-92b5-519bd112d628
Burn, David J.
c03da9e0-b16c-4304-b236-3395dbbe7840
Harris, Clare
ad7c242c-7033-46b4-afd3-398b98f24d85
Morrison, Karen E.
f00890f0-2fde-4dbd-a73b-7422e1b0ede8
Walker, Robert
c8fbfe1c-349d-497f-b24e-0295c84c4634
Romanos, Marcel
5c528f4e-c368-4ad3-956a-02ab952eac73
Gerlach, Manfred
a2eba42f-727a-4120-a774-9d30b2c23813
Berg, Daniela
8c642343-acb1-4b23-aa50-4f3eb5785399
Schulte, Claudia
835f596e-3ee2-4e3c-8b8a-30608c059d48

Geissler, Julia M., Romanos, Marcel, Gerlach, Manfred, Berg, Daniela and Schulte, Claudia , International Parkinson Disease Genomics Consortium members (2017) No genetic association between attention-deficit/hyperactivity disorder (ADHD) and Parkinson’s disease in nine ADHD candidate SNPs. ADHD Attention Deficit and Hyperactivity Disorders, 9 (2), 121-127. (doi:10.1007/s12402-017-0219-8).

Record type: Article

Abstract

Attention-deficit/hyperactivity disorder (ADHD) and Parkinson’s disease (PD) involve pathological changes in brain structures such as the basal ganglia, which are essential for the control of motor and cognitive behavior and impulsivity. The cause of ADHD and PD remains unknown, but there is increasing evidence that both seem to result from a complicated interplay of genetic and environmental factors affecting numerous cellular processes and brain regions. To explore the possibility of common genetic pathways within the respective pathophysiologies, nine ADHD candidate single nucleotide polymorphisms (SNPs) in seven genes were tested for association with PD in 5333 cases and 12,019 healthy controls: one variant, respectively, in the genes coding for synaptosomal-associated protein 25k (SNAP25), the dopamine (DA) transporter (SLC6A3; DAT1), DA receptor D4 (DRD4), serotonin receptor 1B (HTR1B), tryptophan hydroxylase 2 (TPH2), the norepinephrine transporter SLC6A2 and three SNPs in cadherin 13 (CDH13). Information was extracted from a recent meta-analysis of five genome-wide association studies, in which 7,689,524 SNPs in European samples were successfully imputed. No significant association was observed after correction for multiple testing. Therefore, it is reasonable to conclude that candidate variants implicated in the pathogenesis of ADHD do not play a substantial role in PD.

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More information

Accepted/In Press date: 18 January 2017
e-pub ahead of print date: 7 February 2017
Published date: June 2017
Keywords: ADHD, CDH13, Dopamine transporter, GWAS, Parkinson’s disease, SNPs

Identifiers

Local EPrints ID: 417056
URI: http://eprints.soton.ac.uk/id/eprint/417056
ISSN: 1866-6116
PURE UUID: 00557d78-8945-4c52-ac9e-128f44aed469
ORCID for Karen E. Morrison: ORCID iD orcid.org/0000-0003-0216-5717

Catalogue record

Date deposited: 18 Jan 2018 17:30
Last modified: 07 Oct 2020 02:09

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Contributors

Author: Julia M. Geissler
Author: David J. Burn
Author: Clare Harris
Author: Karen E. Morrison ORCID iD
Author: Robert Walker
Author: Marcel Romanos
Author: Manfred Gerlach
Author: Daniela Berg
Author: Claudia Schulte
Corporate Author: International Parkinson Disease Genomics Consortium members

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