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Choroid plexus in the central canal of the spinal cord causing recurrent syringomyelia

Choroid plexus in the central canal of the spinal cord causing recurrent syringomyelia
Choroid plexus in the central canal of the spinal cord causing recurrent syringomyelia

BACKGROUND: Syringomyelia is a fluid filled cavitation within the substance of the spinal cord. This condition usually follows a primary pathology that disrupts the normal CSF circulation or disturbs the microcirculation and cytoarchitecture of the spinal cord parenchyma. However, an aetiology of recurrent syringomyelia resulted from an ectopic choroid plexus (CP) has not been discussed. Ectopic CP rests may be found within the central nervous system. Although there has been a single report, describing ectopic intramedullary spinal cord CP, to our knowledge, extra-cranial non-malignant CP in the central canal of the spinal cord has not been reported.

CASE DESCRIPTION: We report CP in the central canal of the spinal cord in a 23-year-old male patient who had developmental delay and diabetes mellitus type I who presented with dissociated sensory changes and muscle wastage predominantly on the right upper and lower limbs. MRI demonstrated a multi-loculated spinal cord syringomyelia stretching from cervical (C3) to the conus medullaris causing recurrent neurological deficits. Central canal spinal cord lesion's biopsy revealed CP. Decompression and syringo-subarachnoid shunt insertion stabilised the patient's neurology.

CONCLUSION: Our illustrative case reveals the presence of CP in the central canal of the spinal cord that may suggest a role in the aetiology of recurrent syringomyelia. While management poses a challenge to neurosurgeons, prompt decompression and shunting of the syringomyelia remains a favourable approach with acceptable outcomes. Further investigation into the pathophysiology of central canal CP ectopic causing recurrent syringomyelia and its correlation with spinal cord development may help future treatments.

Journal Article
1878-8750
Shtaya, Anan
7b9d3363-83f4-41a9-ae6d-3de05cabb937
Sadek, Ahmed-Ramadan
745c319c-82b0-4eb4-b8ea-48ea7be1f2fa
Nicoll, James A.R.
88c0685f-000e-4eb7-8f72-f36b4985e8ed
Nader-Sepahi, Ali
477f6a66-ee44-4e00-8c77-782050804e99
Shtaya, Anan
7b9d3363-83f4-41a9-ae6d-3de05cabb937
Sadek, Ahmed-Ramadan
745c319c-82b0-4eb4-b8ea-48ea7be1f2fa
Nicoll, James A.R.
88c0685f-000e-4eb7-8f72-f36b4985e8ed
Nader-Sepahi, Ali
477f6a66-ee44-4e00-8c77-782050804e99

Shtaya, Anan, Sadek, Ahmed-Ramadan, Nicoll, James A.R. and Nader-Sepahi, Ali (2017) Choroid plexus in the central canal of the spinal cord causing recurrent syringomyelia. World Neurosurgery. (doi:10.1016/j.wneu.2017.12.143).

Record type: Article

Abstract

BACKGROUND: Syringomyelia is a fluid filled cavitation within the substance of the spinal cord. This condition usually follows a primary pathology that disrupts the normal CSF circulation or disturbs the microcirculation and cytoarchitecture of the spinal cord parenchyma. However, an aetiology of recurrent syringomyelia resulted from an ectopic choroid plexus (CP) has not been discussed. Ectopic CP rests may be found within the central nervous system. Although there has been a single report, describing ectopic intramedullary spinal cord CP, to our knowledge, extra-cranial non-malignant CP in the central canal of the spinal cord has not been reported.

CASE DESCRIPTION: We report CP in the central canal of the spinal cord in a 23-year-old male patient who had developmental delay and diabetes mellitus type I who presented with dissociated sensory changes and muscle wastage predominantly on the right upper and lower limbs. MRI demonstrated a multi-loculated spinal cord syringomyelia stretching from cervical (C3) to the conus medullaris causing recurrent neurological deficits. Central canal spinal cord lesion's biopsy revealed CP. Decompression and syringo-subarachnoid shunt insertion stabilised the patient's neurology.

CONCLUSION: Our illustrative case reveals the presence of CP in the central canal of the spinal cord that may suggest a role in the aetiology of recurrent syringomyelia. While management poses a challenge to neurosurgeons, prompt decompression and shunting of the syringomyelia remains a favourable approach with acceptable outcomes. Further investigation into the pathophysiology of central canal CP ectopic causing recurrent syringomyelia and its correlation with spinal cord development may help future treatments.

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1-s2.0-S1878875017322593-main - Accepted Manuscript
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More information

Accepted/In Press date: 21 December 2017
e-pub ahead of print date: 30 December 2017
Additional Information: Copyright © 2017 Elsevier Inc. All rights reserved.
Keywords: Journal Article

Identifiers

Local EPrints ID: 417091
URI: https://eprints.soton.ac.uk/id/eprint/417091
ISSN: 1878-8750
PURE UUID: 567eba8d-164c-4623-981c-b33e301a3af3
ORCID for James A.R. Nicoll: ORCID iD orcid.org/0000-0002-9444-7246

Catalogue record

Date deposited: 19 Jan 2018 17:30
Last modified: 20 Jul 2019 04:34

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