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Clay nanoparticles for regenerative medicine and biomaterial design: a review of clay bioactivity

Clay nanoparticles for regenerative medicine and biomaterial design: a review of clay bioactivity
Clay nanoparticles for regenerative medicine and biomaterial design: a review of clay bioactivity
Clay nanoparticles, composites and hydrogels are emerging as a new class of biomaterial with exciting potential for tissue engineering and regenerative medicine applications. Clay particles have been extensively explored in polymeric nanocomposites for self-assembly and enhanced mechanical properties as well as for their potential as drug delivery modifiers. In recent years, a cluster of studies have explored cellular interactions with clay nanoparticles alone or in combination with polymeric matrices. These pioneering studies have suggested new and unforeseen utility for certain clays as bioactive additives able to enhance cellular functions including adhesion, proliferation and differentiation, most notably for osteogenesis. This review examines the recent literature describing the potential effects of clay-based nanomaterials on cell function and examines the potential role of key clay physicochemical properties in influencing such interactions and their exciting possibilities for regenerative medicine.
0142-9612
1-28
Mousa, Mohamed
f415be35-3a79-48c2-b6f5-e03fc564c5e2
Evans, Nicholas D.
06a05c97-bfed-4abb-9244-34ec9f4b4b95
Oreffo, Richard O.C.
ff9fff72-6855-4d0f-bfb2-311d0e8f3778
Dawson, Jonathan I.
b220fe76-498d-47be-9995-92da6c289cf3
Mousa, Mohamed
f415be35-3a79-48c2-b6f5-e03fc564c5e2
Evans, Nicholas D.
06a05c97-bfed-4abb-9244-34ec9f4b4b95
Oreffo, Richard O.C.
ff9fff72-6855-4d0f-bfb2-311d0e8f3778
Dawson, Jonathan I.
b220fe76-498d-47be-9995-92da6c289cf3

Mousa, Mohamed, Evans, Nicholas D., Oreffo, Richard O.C. and Dawson, Jonathan I. (2018) Clay nanoparticles for regenerative medicine and biomaterial design: a review of clay bioactivity Biomaterials, pp. 1-28. (doi:10.1016/j.biomaterials.2017.12.024).

Record type: Review

Abstract

Clay nanoparticles, composites and hydrogels are emerging as a new class of biomaterial with exciting potential for tissue engineering and regenerative medicine applications. Clay particles have been extensively explored in polymeric nanocomposites for self-assembly and enhanced mechanical properties as well as for their potential as drug delivery modifiers. In recent years, a cluster of studies have explored cellular interactions with clay nanoparticles alone or in combination with polymeric matrices. These pioneering studies have suggested new and unforeseen utility for certain clays as bioactive additives able to enhance cellular functions including adhesion, proliferation and differentiation, most notably for osteogenesis. This review examines the recent literature describing the potential effects of clay-based nanomaterials on cell function and examines the potential role of key clay physicochemical properties in influencing such interactions and their exciting possibilities for regenerative medicine.

Text 1-s2.0-S0142961217308335-main - Accepted Manuscript
Restricted to Repository staff only until 3 January 2019.
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Accepted/In Press date: 3 January 2018
e-pub ahead of print date: 3 January 2018

Identifiers

Local EPrints ID: 417207
URI: https://eprints.soton.ac.uk/id/eprint/417207
ISSN: 0142-9612
PURE UUID: 2b18052f-1738-4b30-87fd-7d78b6dbe29e
ORCID for Richard O.C. Oreffo: ORCID iD orcid.org/0000-0001-5995-6726

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Date deposited: 25 Jan 2018 17:30
Last modified: 31 Jan 2018 17:30

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