Neuroinflammation: microglia and T cells get ready to tango
Neuroinflammation: microglia and T cells get ready to tango
In recent years, many paradigms concerning central nervous system (CNS) immunology have been challenged and shifted, including the discovery of CNS-draining lymphatic vessels, the origin and functional diversity of microglia, the impact of T cells on CNS immunological homeostasis and the role of neuroinflammation in neurodegenerative diseases. In parallel, antigen presentation outside the CNS has revealed the vital role of antigen-presenting cells in maintaining tolerance toward self-proteins, thwarting auto-immunity. Here, we review recent findings that unite these shifted paradigms of microglial functioning, antigen presentation, and CNS-directed T cell activation, focusing on common neurodegenerative diseases. It provides an important update on CNS adaptive immunity, novel targets, and a concept of the microglia T-cell equilibrium.
1-11
Schetters, Sjoerd T.T.
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Gomez-Nicola, Diego
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Garcia-Vallejo, Juan J.
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Van Kooyk, Y.
7554dfb7-cb8a-4479-89ee-c18d23970c38
Schetters, Sjoerd T.T.
548c72ad-c3ad-41de-a9f5-d566065160de
Gomez-Nicola, Diego
0680aa66-9dee-47cf-a8d3-e39c988f85b5
Garcia-Vallejo, Juan J.
a2f390a7-eb2e-41e1-baa5-caea4c51e691
Van Kooyk, Y.
7554dfb7-cb8a-4479-89ee-c18d23970c38
Schetters, Sjoerd T.T., Gomez-Nicola, Diego, Garcia-Vallejo, Juan J. and Van Kooyk, Y.
(2018)
Neuroinflammation: microglia and T cells get ready to tango.
Frontiers in Immunology, .
(doi:10.3389/fimmu.2017.01905).
Abstract
In recent years, many paradigms concerning central nervous system (CNS) immunology have been challenged and shifted, including the discovery of CNS-draining lymphatic vessels, the origin and functional diversity of microglia, the impact of T cells on CNS immunological homeostasis and the role of neuroinflammation in neurodegenerative diseases. In parallel, antigen presentation outside the CNS has revealed the vital role of antigen-presenting cells in maintaining tolerance toward self-proteins, thwarting auto-immunity. Here, we review recent findings that unite these shifted paradigms of microglial functioning, antigen presentation, and CNS-directed T cell activation, focusing on common neurodegenerative diseases. It provides an important update on CNS adaptive immunity, novel targets, and a concept of the microglia T-cell equilibrium.
Text
fimmu-08-01905
- Version of Record
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Accepted/In Press date: 13 December 2017
e-pub ahead of print date: 25 January 2018
Identifiers
Local EPrints ID: 417209
URI: http://eprints.soton.ac.uk/id/eprint/417209
ISSN: 1664-3224
PURE UUID: d01600a9-d4f6-435a-bb19-ba09a96fc170
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Date deposited: 25 Jan 2018 17:30
Last modified: 16 Mar 2024 04:04
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Contributors
Author:
Sjoerd T.T. Schetters
Author:
Juan J. Garcia-Vallejo
Author:
Y. Van Kooyk
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