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Constitutive modelling of the skin accounting for chronological ageing

Constitutive modelling of the skin accounting for chronological ageing
Constitutive modelling of the skin accounting for chronological ageing
A multiphasic constitutive model of the skin capturing the process of intrinsic (i.e. chronological) ageing is proposed. The structurally-motivated constitutive formulation features distinct mechanical contributions from collagen and elastin fibres. The central hypothesis underpinning this study is that the effects of ageing on the mechanical properties of the tissue are directly linked to alterations in the microstructural characteristics of the collagen and elastin networks. Constitutive parameters in the model, corresponding to different ages, are identified from published experimental data on bulge tests of human skin. The identification procedure is based on an inverse finite element method. The numerical results demonstrate that degradation of the elastin mesh work and variations in anisotropy of the collagen network are plausible mechanisms to explain ageing in terms of macroscopic tissue stiffening. Whereas alterations in elastin affect the low-modulus region of the skin stress-strain curve, those related to collagen have an impact on the linear region.
soft tissue , microstructure, anisotropy, collagen, elastin, bulge test, continuum mechanics, ?finite element method
0022-5193
Pond, Damien
4233e4fa-a790-4ade-a0c3-f3099d6e88a1
McBride, Andrew
808d8e40-731d-4b1e-9ca6-5c5a6951132a
Davids, Lester
078a0608-dd47-4b5e-b47e-39d224308535
Reddy, B. Daya
2ad242d6-688c-417d-ba3b-76184d7e2be6
Limbert, Georges
a1b88cb4-c5d9-4c6e-b6c9-7f4c4aa1c2ec
Pond, Damien
4233e4fa-a790-4ade-a0c3-f3099d6e88a1
McBride, Andrew
808d8e40-731d-4b1e-9ca6-5c5a6951132a
Davids, Lester
078a0608-dd47-4b5e-b47e-39d224308535
Reddy, B. Daya
2ad242d6-688c-417d-ba3b-76184d7e2be6
Limbert, Georges
a1b88cb4-c5d9-4c6e-b6c9-7f4c4aa1c2ec

Pond, Damien, McBride, Andrew, Davids, Lester, Reddy, B. Daya and Limbert, Georges (2018) Constitutive modelling of the skin accounting for chronological ageing Journal of Theoretical Biology (In Press).

Record type: Article

Abstract

A multiphasic constitutive model of the skin capturing the process of intrinsic (i.e. chronological) ageing is proposed. The structurally-motivated constitutive formulation features distinct mechanical contributions from collagen and elastin fibres. The central hypothesis underpinning this study is that the effects of ageing on the mechanical properties of the tissue are directly linked to alterations in the microstructural characteristics of the collagen and elastin networks. Constitutive parameters in the model, corresponding to different ages, are identified from published experimental data on bulge tests of human skin. The identification procedure is based on an inverse finite element method. The numerical results demonstrate that degradation of the elastin mesh work and variations in anisotropy of the collagen network are plausible mechanisms to explain ageing in terms of macroscopic tissue stiffening. Whereas alterations in elastin affect the low-modulus region of the skin stress-strain curve, those related to collagen have an impact on the linear region.

Text JTB-S-17-00968 v2 - Accepted Manuscript
Restricted to Repository staff only until 15 April 2019.
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More information

Accepted/In Press date: 15 January 2018
Keywords: soft tissue , microstructure, anisotropy, collagen, elastin, bulge test, continuum mechanics, ?finite element method

Identifiers

Local EPrints ID: 417299
URI: https://eprints.soton.ac.uk/id/eprint/417299
ISSN: 0022-5193
PURE UUID: d4369a14-18c9-4352-969d-e09d06d1d47b

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Date deposited: 29 Jan 2018 17:30
Last modified: 29 Jan 2018 17:30

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Contributors

Author: Damien Pond
Author: Andrew McBride
Author: Lester Davids
Author: B. Daya Reddy
Author: Georges Limbert

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