What has been learnt from study of dopamine receptors in Parkinson's disease?
What has been learnt from study of dopamine receptors in Parkinson's disease?
Since the introduction of dopamine replacement therapy using L-3,4-dihydroxyphenyalanine (L-DOPA) to treat Parkinson's disease and the recognition of the problems associated with L-DOPA use, numerous studies have investigated dopamine receptor regulation and function in Parkinson's disease. These studies have provided insight into the pathological process of the disorder and the molecular consequences of chronic dopaminergic treatment, but they have been less successful in identifying new pharmacological targets or treatment regimes that are as effective as L-DOPA at alleviating the symptoms of Parkinson's disease. This review will present a summary of the reported changes in dopamine receptor regulation and function that occur in Parkinson's disease and will discuss their contribution to the current pharmacological management of Parkinson's disease.
Animals, Genes, Immediate-Early, Humans, Levodopa, Parkinson Disease, Receptors, Dopamine, Receptors, Dopamine D1, Receptors, Dopamine D2, Receptors, N-Methyl-D-Aspartate, Signal Transduction, Journal Article, Research Support, Non-U.S. Gov't, Review
715-728
Hurley, M.J.
07b0180f-8e32-4ce1-8185-e046a42ef15a
Jenner, P.
785c25df-ec64-4181-b057-26dd31cd9d84
September 2006
Hurley, M.J.
07b0180f-8e32-4ce1-8185-e046a42ef15a
Jenner, P.
785c25df-ec64-4181-b057-26dd31cd9d84
Hurley, M.J. and Jenner, P.
(2006)
What has been learnt from study of dopamine receptors in Parkinson's disease?
Pharmacology & Therapeutics, 111 (3), .
(doi:10.1016/j.pharmthera.2005.12.001).
Abstract
Since the introduction of dopamine replacement therapy using L-3,4-dihydroxyphenyalanine (L-DOPA) to treat Parkinson's disease and the recognition of the problems associated with L-DOPA use, numerous studies have investigated dopamine receptor regulation and function in Parkinson's disease. These studies have provided insight into the pathological process of the disorder and the molecular consequences of chronic dopaminergic treatment, but they have been less successful in identifying new pharmacological targets or treatment regimes that are as effective as L-DOPA at alleviating the symptoms of Parkinson's disease. This review will present a summary of the reported changes in dopamine receptor regulation and function that occur in Parkinson's disease and will discuss their contribution to the current pharmacological management of Parkinson's disease.
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e-pub ahead of print date: 3 February 2006
Published date: September 2006
Keywords:
Animals, Genes, Immediate-Early, Humans, Levodopa, Parkinson Disease, Receptors, Dopamine, Receptors, Dopamine D1, Receptors, Dopamine D2, Receptors, N-Methyl-D-Aspartate, Signal Transduction, Journal Article, Research Support, Non-U.S. Gov't, Review
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Local EPrints ID: 417316
URI: http://eprints.soton.ac.uk/id/eprint/417316
ISSN: 0163-7258
PURE UUID: d22b4ddf-9dca-4097-a010-b906671db806
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Date deposited: 29 Jan 2018 17:30
Last modified: 15 Mar 2024 17:13
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Author:
M.J. Hurley
Author:
P. Jenner
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