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An interleukin-1 genotype is associated with fatal outcome of meningococcal disease

An interleukin-1 genotype is associated with fatal outcome of meningococcal disease
An interleukin-1 genotype is associated with fatal outcome of meningococcal disease

To determine whether known variants of the interleukin-1 (IL-1) and tumor necrosis factor (TNF) gene families are associated with severe manifestations of meningococcal disease, 276 white patients 4-70 years of age (median, 17 years) were genotyped. All patients had microbiologically proven Neisseria meningitidis infection; 39 died and 237 survived. A significant association (P<.001) was found between fatal outcome and genotype at IL1B (nucleotide position -511). Homozygous individuals, both for the common (1/1) and the rare (2/2) alleles, had increased odds ratios (ORs) for death, compared with heterozygous individuals (1/2): ORs (95% confidence intervals [CIs]) were 3.39 (1.39-8.29) and 7.35 (2.51-21.45), respectively. The mortality rates according to genotype at IL1B (-511) were 18.0% (1/1), 6.1% (1/2), and 32.3% (2/2), compared with 14.2% overall. The composite genotype, consisting of heterozygosity of IL1B (-511) together with homozygosity of the common allele of the IL-1 receptor antagonist gene (IL1RN) at +2018, was significantly associated with survival (P=.018; OR, 7.78 [95% CI, 1. 05-59.05]). There was no association between TNF genotype and fatal outcome. These data suggest that IL-1 genotype influences the severity of meningococcal disease.

Adolescent, Adult, Aged, Child, Child, Preschool, Genotype, Humans, Interleukin-1, Meningococcal Infections, Middle Aged, Polymorphism, Genetic, Tumor Necrosis Factor-alpha, Journal Article, Research Support, Non-U.S. Gov't
0022-1899
1557-1560
Read, R.C.
b5caca7b-0063-438a-b703-7ecbb6fc2b51
Camp, N.J.
d4eb07e5-5c78-4a79-9525-591325c7fd1e
di Giovine, F.S.
56266edf-877e-424e-adaf-07b7580c2b90
Borrow, R.
ae200ab8-f9f3-49c6-a161-c8fc31d00a58
Kaczmarski, E.B.
b64d93b8-aaee-44f6-a7a3-715f8971d3b3
Chaudhary, A.G.
365397fd-15c6-4f9d-9d29-ad7c7595ff52
Fox, A.J.
78d97a48-fce3-4a3c-ab4b-59bc9e8e1813
Duff, G.W.
bc399880-5c30-42cd-854a-30f9c9bde43c
Read, R.C.
b5caca7b-0063-438a-b703-7ecbb6fc2b51
Camp, N.J.
d4eb07e5-5c78-4a79-9525-591325c7fd1e
di Giovine, F.S.
56266edf-877e-424e-adaf-07b7580c2b90
Borrow, R.
ae200ab8-f9f3-49c6-a161-c8fc31d00a58
Kaczmarski, E.B.
b64d93b8-aaee-44f6-a7a3-715f8971d3b3
Chaudhary, A.G.
365397fd-15c6-4f9d-9d29-ad7c7595ff52
Fox, A.J.
78d97a48-fce3-4a3c-ab4b-59bc9e8e1813
Duff, G.W.
bc399880-5c30-42cd-854a-30f9c9bde43c

Read, R.C., Camp, N.J., di Giovine, F.S., Borrow, R., Kaczmarski, E.B., Chaudhary, A.G., Fox, A.J. and Duff, G.W. (2000) An interleukin-1 genotype is associated with fatal outcome of meningococcal disease. The Journal of Infectious Diseases, 182 (5), 1557-1560. (doi:10.1086/315889).

Record type: Article

Abstract

To determine whether known variants of the interleukin-1 (IL-1) and tumor necrosis factor (TNF) gene families are associated with severe manifestations of meningococcal disease, 276 white patients 4-70 years of age (median, 17 years) were genotyped. All patients had microbiologically proven Neisseria meningitidis infection; 39 died and 237 survived. A significant association (P<.001) was found between fatal outcome and genotype at IL1B (nucleotide position -511). Homozygous individuals, both for the common (1/1) and the rare (2/2) alleles, had increased odds ratios (ORs) for death, compared with heterozygous individuals (1/2): ORs (95% confidence intervals [CIs]) were 3.39 (1.39-8.29) and 7.35 (2.51-21.45), respectively. The mortality rates according to genotype at IL1B (-511) were 18.0% (1/1), 6.1% (1/2), and 32.3% (2/2), compared with 14.2% overall. The composite genotype, consisting of heterozygosity of IL1B (-511) together with homozygosity of the common allele of the IL-1 receptor antagonist gene (IL1RN) at +2018, was significantly associated with survival (P=.018; OR, 7.78 [95% CI, 1. 05-59.05]). There was no association between TNF genotype and fatal outcome. These data suggest that IL-1 genotype influences the severity of meningococcal disease.

Full text not available from this repository.

More information

Published date: November 2000
Keywords: Adolescent, Adult, Aged, Child, Child, Preschool, Genotype, Humans, Interleukin-1, Meningococcal Infections, Middle Aged, Polymorphism, Genetic, Tumor Necrosis Factor-alpha, Journal Article, Research Support, Non-U.S. Gov't

Identifiers

Local EPrints ID: 417323
URI: https://eprints.soton.ac.uk/id/eprint/417323
ISSN: 0022-1899
PURE UUID: 017b0dc1-dab9-4207-9670-953ee26e20ca
ORCID for R.C. Read: ORCID iD orcid.org/0000-0002-4297-6728

Catalogue record

Date deposited: 29 Jan 2018 17:30
Last modified: 17 Jul 2019 17:42

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