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Pro-inflammatory dietary pattern is associated with fractures in women: an eight-year longitudinal cohort study

Pro-inflammatory dietary pattern is associated with fractures in women: an eight-year longitudinal cohort study
Pro-inflammatory dietary pattern is associated with fractures in women: an eight-year longitudinal cohort study

Summary: In this study, during 8 years of follow-up, we reported that higher dietary inflammatory index values were associated with a higher risk of incident fractures in women, but not in men, after adjusting for potential confounders. Introduction: Inflammation is a key risk factor for many adverse outcomes in older people. While diet is a potential source of inflammation, little is known about the impact of inflammatory diet on fractures. Thus, we investigated whether higher Dietary Inflammatory Index (DII)™ ® scores are associated with fractures in a cohort of North American people. Methods: This longitudinal study with a follow-up of 8 years included 3648 participants (1577 males and 2071 females; mean age = 60.6 years) with/at risk of knee osteoarthritis participating with in the Osteoarthritis Initiative. DII scores were calculated using the validated Block Brief 2000 Food Frequency Questionnaire, categorized into sex-specific quintiles. Information on fractures was obtained through self-reported history of fractures at hip, spine, and forearm. The relationship between baseline DII score and incident fracture was assessed through a Cox’s regression analysis, adjusted for potential baseline confounders, and reported as hazard ratios (HRs). Results: During 8 years of follow-up, 560 individuals developed fractures (15.4%). Adjusting for 10 potential confounders, women in the highest DII score quintile (i.e., most pro-inflammatory diet) had a significantly higher risk for fractures (HR = 1.46; 95% CI = 1.02–2.11) compared to women in the lowest quintile. An increase in one standard deviation of DII scores significantly predicted fracture onset in women (adjusted HR = 1.14; 95% CI = 1.02–1.27). The association between DII score and fractures was not significant among men or in the sample as whole. Conclusion: Pro-inflammatory diet is associated with a higher incidence of fractures in women but not men.

Aged, Dietary Inflammatory Index, Fracture, Inflammation, Osteoporosis
0937-941X
143-151
Veronese, N.
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Stubbs, B.
bccb7f03-83dc-4c03-82f7-58b89ce91bc5
Koyanagi, A.
217cfa42-a476-47d9-b158-4cfc6aed2719
Hébert, J. R.
3b57991f-f8d2-4322-bbce-ee49e7b43430
Cooper, C.
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Caruso, M. G.
5582cc01-366e-4214-9762-0cd0922231eb
Guglielmi, G.
96941ab7-b5f8-4a0c-a945-edf599fa088f
Reginster, Jean-Yves
db56b103-184d-46e1-9600-f47f7a09a492
Rizzoli, Rene
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Maggi, Stefania
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Shivappa, N.
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Veronese, N.
4abdab1f-9d90-4e04-b6ba-4bb6b71b5381
Stubbs, B.
bccb7f03-83dc-4c03-82f7-58b89ce91bc5
Koyanagi, A.
217cfa42-a476-47d9-b158-4cfc6aed2719
Hébert, J. R.
3b57991f-f8d2-4322-bbce-ee49e7b43430
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Caruso, M. G.
5582cc01-366e-4214-9762-0cd0922231eb
Guglielmi, G.
96941ab7-b5f8-4a0c-a945-edf599fa088f
Reginster, Jean-Yves
db56b103-184d-46e1-9600-f47f7a09a492
Rizzoli, Rene
e02c0d92-6da1-430c-a669-0c20e94a850a
Maggi, Stefania
57e7e62a-b7dd-4291-82e3-efc8c9a7e12a
Shivappa, N.
ab7ce1dc-e4c3-4adc-9a45-cdd62acdfca0

Veronese, N., Stubbs, B., Koyanagi, A., Hébert, J. R., Cooper, C., Caruso, M. G., Guglielmi, G., Reginster, Jean-Yves, Rizzoli, Rene, Maggi, Stefania and Shivappa, N. (2018) Pro-inflammatory dietary pattern is associated with fractures in women: an eight-year longitudinal cohort study. Osteoporosis International, 29 (1), 143-151. (doi:10.1007/s00198-017-4251-5).

Record type: Article

Abstract

Summary: In this study, during 8 years of follow-up, we reported that higher dietary inflammatory index values were associated with a higher risk of incident fractures in women, but not in men, after adjusting for potential confounders. Introduction: Inflammation is a key risk factor for many adverse outcomes in older people. While diet is a potential source of inflammation, little is known about the impact of inflammatory diet on fractures. Thus, we investigated whether higher Dietary Inflammatory Index (DII)™ ® scores are associated with fractures in a cohort of North American people. Methods: This longitudinal study with a follow-up of 8 years included 3648 participants (1577 males and 2071 females; mean age = 60.6 years) with/at risk of knee osteoarthritis participating with in the Osteoarthritis Initiative. DII scores were calculated using the validated Block Brief 2000 Food Frequency Questionnaire, categorized into sex-specific quintiles. Information on fractures was obtained through self-reported history of fractures at hip, spine, and forearm. The relationship between baseline DII score and incident fracture was assessed through a Cox’s regression analysis, adjusted for potential baseline confounders, and reported as hazard ratios (HRs). Results: During 8 years of follow-up, 560 individuals developed fractures (15.4%). Adjusting for 10 potential confounders, women in the highest DII score quintile (i.e., most pro-inflammatory diet) had a significantly higher risk for fractures (HR = 1.46; 95% CI = 1.02–2.11) compared to women in the lowest quintile. An increase in one standard deviation of DII scores significantly predicted fracture onset in women (adjusted HR = 1.14; 95% CI = 1.02–1.27). The association between DII score and fractures was not significant among men or in the sample as whole. Conclusion: Pro-inflammatory diet is associated with a higher incidence of fractures in women but not men.

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More information

Accepted/In Press date: 27 September 2017
e-pub ahead of print date: 10 October 2017
Published date: 1 January 2018
Keywords: Aged, Dietary Inflammatory Index, Fracture, Inflammation, Osteoporosis

Identifiers

Local EPrints ID: 417329
URI: http://eprints.soton.ac.uk/id/eprint/417329
ISSN: 0937-941X
PURE UUID: edfa252a-f89f-4722-9cea-cb8b8d15fb69
ORCID for C. Cooper: ORCID iD orcid.org/0000-0003-3510-0709

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Date deposited: 30 Jan 2018 17:30
Last modified: 07 Oct 2020 01:40

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Contributors

Author: N. Veronese
Author: B. Stubbs
Author: A. Koyanagi
Author: J. R. Hébert
Author: C. Cooper ORCID iD
Author: M. G. Caruso
Author: G. Guglielmi
Author: Jean-Yves Reginster
Author: Rene Rizzoli
Author: Stefania Maggi
Author: N. Shivappa

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