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Toll receptors and sepsis

Toll receptors and sepsis
Toll receptors and sepsis

Toll-like receptors are a family of receptors that recognize components of bacteria and induce a proinflammatory response by cells, including macrophages and endothelial cells. Ten human Toll receptors differing in their specificity for microbial components have been cloned. They respond to various components, including lipopolysaccharide of Gram-negative bacteria, lipopeptides of Gram-positive cell walls, bacterial DNA, and flagella. Some Toll-like receptors require the cooperation of an adapter protein. Toll-like receptor 4 function requires the presence of the protein MD2. Recently, it has been shown that Toll-like receptors function cooperatively to increase the specificity of response to a given microbe. Human polymorphisms of Toll-like receptor genes have been discovered and are associated with hyporesponsiveness to bacterial components.

Animals, DNA, Bacterial, Drosophila Proteins, Genetic Variation, Humans, Immunity, Innate, Membrane Glycoproteins, Receptors, Cell Surface, Sepsis, Signal Transduction, Toll-Like Receptor 4, Toll-Like Receptors, Journal Article, Review
1070-5295
371-375
Read, R.C.
b5caca7b-0063-438a-b703-7ecbb6fc2b51
Wyllie, D.H.
3ec8a490-efb4-4c0a-b2c4-7299b74c61b5
Read, R.C.
b5caca7b-0063-438a-b703-7ecbb6fc2b51
Wyllie, D.H.
3ec8a490-efb4-4c0a-b2c4-7299b74c61b5

Read, R.C. and Wyllie, D.H. (2001) Toll receptors and sepsis. Current Opinion in Critical Care, 7 (5), 371-375.

Record type: Article

Abstract

Toll-like receptors are a family of receptors that recognize components of bacteria and induce a proinflammatory response by cells, including macrophages and endothelial cells. Ten human Toll receptors differing in their specificity for microbial components have been cloned. They respond to various components, including lipopolysaccharide of Gram-negative bacteria, lipopeptides of Gram-positive cell walls, bacterial DNA, and flagella. Some Toll-like receptors require the cooperation of an adapter protein. Toll-like receptor 4 function requires the presence of the protein MD2. Recently, it has been shown that Toll-like receptors function cooperatively to increase the specificity of response to a given microbe. Human polymorphisms of Toll-like receptor genes have been discovered and are associated with hyporesponsiveness to bacterial components.

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More information

Published date: October 2001
Keywords: Animals, DNA, Bacterial, Drosophila Proteins, Genetic Variation, Humans, Immunity, Innate, Membrane Glycoproteins, Receptors, Cell Surface, Sepsis, Signal Transduction, Toll-Like Receptor 4, Toll-Like Receptors, Journal Article, Review

Identifiers

Local EPrints ID: 417399
URI: https://eprints.soton.ac.uk/id/eprint/417399
ISSN: 1070-5295
PURE UUID: 2e4f540f-7ee5-4da5-9730-d17c33803850
ORCID for R.C. Read: ORCID iD orcid.org/0000-0002-4297-6728

Catalogue record

Date deposited: 30 Jan 2018 17:31
Last modified: 20 Jul 2019 00:42

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