The University of Southampton
University of Southampton Institutional Repository
Warning ePrints Soton is experiencing an issue with some file downloads not being available. We are working hard to fix this. Please bear with us.

Variation within genes encoding interleukin-1 and the interleukin-1 receptor antagonist influence the severity of meningococcal disease

Variation within genes encoding interleukin-1 and the interleukin-1 receptor antagonist influence the severity of meningococcal disease
Variation within genes encoding interleukin-1 and the interleukin-1 receptor antagonist influence the severity of meningococcal disease

BACKGROUND: Genetically determined variation in proinflammatory cytokine release influences severity of meningococcal disease and other serious infections.

OBJECTIVE: To ascertain the relative frequencies of single nucleotide polymorphisms within the interleukin-1 gene locus among patients who survived and those who died of meningococcal disease and a control population of blood donors.

DESIGN: Association study.

SETTING: England and Wales.

PATIENTS: 1106 consecutively received blood samples from persons with microbiologically confirmed meningococcal disease and 839 samples from blood donors.

MEASUREMENTS: Patient demographic and outcome data, infecting meningococcal serogroups, and genotype at the IL1B(-511) and IL1RN(+2018) loci of patients and blood donor controls.

RESULTS: Genotype frequency did not differ between patients with meningococcal disease and blood donor controls. Logistic regression analysis revealed that the likelihood of death was significantly influenced by age but not socioeconomic status and was higher in patients who were infected with serogroup C (odds ratio for survival, 0.50 [95% CI, 0.33 to 0.78]). Patients carrying the common allele at IL1B(-511) were more likely to survive (odds ratio, 2.01 [CI, 1.11 to 3.79]). Patients with this allele were less likely to survive if they also carried the rare allele at IL1RN(+2018) (odds ratio, 0.61 [CI, 0.38 to 0.993]).

CONCLUSION: Genotype at the interleukin-1 gene locus influences likelihood of survival of meningococcal disease but has no effect on susceptibility to the infection. Increasing age and infection with serogroup C also influence the likelihood of death.

Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Alleles, Child, Child, Preschool, England, Genetic Variation, Genotype, Humans, Infant, Infant, Newborn, Interleukin 1 Receptor Antagonist Protein, Interleukin-1, Meningococcal Infections, Middle Aged, Sialoglycoproteins, Socioeconomic Factors, Wales, Journal Article, Research Support, Non-U.S. Gov't
0003-4819
534-41
Read, Robert C.
b5caca7b-0063-438a-b703-7ecbb6fc2b51
Cannings, Chris
1d53c1b0-35b7-42ea-ab2a-b75723ef26d3
Naylor, Simone C.
d0233f03-8cc1-445d-ad95-9d4bacb16f6c
Timms, Janine M.
04ec5ad5-b25f-4554-8582-eb1c9bb20913
Maheswaran, Ravi
d0372689-622d-444d-86e5-7b7b9ddbe4fd
Borrow, Raymond
dd28679e-2072-4639-9d68-851ada2eeea3
Kaczmarski, Edward B.
b64d93b8-aaee-44f6-a7a3-715f8971d3b3
Duff, Gordon W.
bc399880-5c30-42cd-854a-30f9c9bde43c
Read, Robert C.
b5caca7b-0063-438a-b703-7ecbb6fc2b51
Cannings, Chris
1d53c1b0-35b7-42ea-ab2a-b75723ef26d3
Naylor, Simone C.
d0233f03-8cc1-445d-ad95-9d4bacb16f6c
Timms, Janine M.
04ec5ad5-b25f-4554-8582-eb1c9bb20913
Maheswaran, Ravi
d0372689-622d-444d-86e5-7b7b9ddbe4fd
Borrow, Raymond
dd28679e-2072-4639-9d68-851ada2eeea3
Kaczmarski, Edward B.
b64d93b8-aaee-44f6-a7a3-715f8971d3b3
Duff, Gordon W.
bc399880-5c30-42cd-854a-30f9c9bde43c

Read, Robert C., Cannings, Chris, Naylor, Simone C., Timms, Janine M., Maheswaran, Ravi, Borrow, Raymond, Kaczmarski, Edward B. and Duff, Gordon W. (2003) Variation within genes encoding interleukin-1 and the interleukin-1 receptor antagonist influence the severity of meningococcal disease. Annals of Internal Medicine, 138 (7), 534-41. (doi:10.7326/0003-4819-138-7-200304010-00009).

Record type: Article

Abstract

BACKGROUND: Genetically determined variation in proinflammatory cytokine release influences severity of meningococcal disease and other serious infections.

OBJECTIVE: To ascertain the relative frequencies of single nucleotide polymorphisms within the interleukin-1 gene locus among patients who survived and those who died of meningococcal disease and a control population of blood donors.

DESIGN: Association study.

SETTING: England and Wales.

PATIENTS: 1106 consecutively received blood samples from persons with microbiologically confirmed meningococcal disease and 839 samples from blood donors.

MEASUREMENTS: Patient demographic and outcome data, infecting meningococcal serogroups, and genotype at the IL1B(-511) and IL1RN(+2018) loci of patients and blood donor controls.

RESULTS: Genotype frequency did not differ between patients with meningococcal disease and blood donor controls. Logistic regression analysis revealed that the likelihood of death was significantly influenced by age but not socioeconomic status and was higher in patients who were infected with serogroup C (odds ratio for survival, 0.50 [95% CI, 0.33 to 0.78]). Patients carrying the common allele at IL1B(-511) were more likely to survive (odds ratio, 2.01 [CI, 1.11 to 3.79]). Patients with this allele were less likely to survive if they also carried the rare allele at IL1RN(+2018) (odds ratio, 0.61 [CI, 0.38 to 0.993]).

CONCLUSION: Genotype at the interleukin-1 gene locus influences likelihood of survival of meningococcal disease but has no effect on susceptibility to the infection. Increasing age and infection with serogroup C also influence the likelihood of death.

This record has no associated files available for download.

More information

Published date: 1 April 2003
Keywords: Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Alleles, Child, Child, Preschool, England, Genetic Variation, Genotype, Humans, Infant, Infant, Newborn, Interleukin 1 Receptor Antagonist Protein, Interleukin-1, Meningococcal Infections, Middle Aged, Sialoglycoproteins, Socioeconomic Factors, Wales, Journal Article, Research Support, Non-U.S. Gov't

Identifiers

Local EPrints ID: 417400
URI: http://eprints.soton.ac.uk/id/eprint/417400
ISSN: 0003-4819
PURE UUID: 3f81f4d7-1a85-4cfc-b6ad-017eb65d5ae8
ORCID for Robert C. Read: ORCID iD orcid.org/0000-0002-4297-6728

Catalogue record

Date deposited: 30 Jan 2018 17:31
Last modified: 10 Nov 2021 03:30

Export record

Altmetrics

Contributors

Author: Robert C. Read ORCID iD
Author: Chris Cannings
Author: Simone C. Naylor
Author: Janine M. Timms
Author: Ravi Maheswaran
Author: Raymond Borrow
Author: Edward B. Kaczmarski
Author: Gordon W. Duff

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×