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Effective nasal influenza vaccine delivery using chitosan

Effective nasal influenza vaccine delivery using chitosan
Effective nasal influenza vaccine delivery using chitosan

Nasal influenza vaccination may prove to be a good alternative to parenteral injection because of the enhancement of the mucosal immune response and the ease of vaccine administration. This study investigated the use of chitosan, a bioadhesive polymer, as a nasal delivery system with inactivated, subunit influenza vaccine. Subjects received nasally 15 or 7.5 microg of the standard inactivated trivalent influenza vaccine with chitosan or 15 microg of the same vaccine intramuscularly. Serum haemagglutination inhibition (HI) titres for all three vaccine components were measured prior to, and at time points up to 14 weeks after dosing. Serum HI titres following intranasal vaccination with the nasal chitosan-influenza vaccine met the criteria set by the Committee for Proprietary Medicinal Products in terms of seroprotection rate, seroconversion rate and mean fold increase of HI titre for at least one of the three antigens in the vaccination schedules used. These data show that nasal immunisation with chitosan plus trivalent inactivated influenza is a potentially effective, easily-administered form of vaccination.

Administration, Intranasal, Adolescent, Adult, Chitin, Chitosan, Drug Delivery Systems, Female, Hemagglutination Inhibition Tests, Humans, Influenza Vaccines, Male, Middle Aged, Vaccination, Vaccines, Attenuated, Journal Article
0264-410X
4367-4374
Read, Robert C.
b5caca7b-0063-438a-b703-7ecbb6fc2b51
Naylor, Simone C.
d0233f03-8cc1-445d-ad95-9d4bacb16f6c
Potter, Christopher W.
ac01161b-69ce-4f56-8808-26ba90a56d16
Bond, Jenny
abb7f8c8-1b4e-4b26-a1f7-fbee4b8ed8c2
Jabbal-Gill, Inderjit
eab4da6a-c016-4774-ad07-5cf3174ac50f
Fisher, Anthony
549d479f-c5c5-4f96-add1-afccc07ee098
Illum, Lisbeth
673e37e2-913f-41f9-adfd-94c11adff894
Jennings, Roy
85266aa1-6fe8-4fe4-8525-0c665e138e0f
Read, Robert C.
b5caca7b-0063-438a-b703-7ecbb6fc2b51
Naylor, Simone C.
d0233f03-8cc1-445d-ad95-9d4bacb16f6c
Potter, Christopher W.
ac01161b-69ce-4f56-8808-26ba90a56d16
Bond, Jenny
abb7f8c8-1b4e-4b26-a1f7-fbee4b8ed8c2
Jabbal-Gill, Inderjit
eab4da6a-c016-4774-ad07-5cf3174ac50f
Fisher, Anthony
549d479f-c5c5-4f96-add1-afccc07ee098
Illum, Lisbeth
673e37e2-913f-41f9-adfd-94c11adff894
Jennings, Roy
85266aa1-6fe8-4fe4-8525-0c665e138e0f

Read, Robert C., Naylor, Simone C., Potter, Christopher W., Bond, Jenny, Jabbal-Gill, Inderjit, Fisher, Anthony, Illum, Lisbeth and Jennings, Roy (2005) Effective nasal influenza vaccine delivery using chitosan. Vaccine, 23 (35), 4367-4374. (doi:10.1016/j.vaccine.2005.04.021).

Record type: Article

Abstract

Nasal influenza vaccination may prove to be a good alternative to parenteral injection because of the enhancement of the mucosal immune response and the ease of vaccine administration. This study investigated the use of chitosan, a bioadhesive polymer, as a nasal delivery system with inactivated, subunit influenza vaccine. Subjects received nasally 15 or 7.5 microg of the standard inactivated trivalent influenza vaccine with chitosan or 15 microg of the same vaccine intramuscularly. Serum haemagglutination inhibition (HI) titres for all three vaccine components were measured prior to, and at time points up to 14 weeks after dosing. Serum HI titres following intranasal vaccination with the nasal chitosan-influenza vaccine met the criteria set by the Committee for Proprietary Medicinal Products in terms of seroprotection rate, seroconversion rate and mean fold increase of HI titre for at least one of the three antigens in the vaccination schedules used. These data show that nasal immunisation with chitosan plus trivalent inactivated influenza is a potentially effective, easily-administered form of vaccination.

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More information

Accepted/In Press date: 18 April 2005
e-pub ahead of print date: 12 May 2005
Published date: 15 August 2005
Keywords: Administration, Intranasal, Adolescent, Adult, Chitin, Chitosan, Drug Delivery Systems, Female, Hemagglutination Inhibition Tests, Humans, Influenza Vaccines, Male, Middle Aged, Vaccination, Vaccines, Attenuated, Journal Article

Identifiers

Local EPrints ID: 417401
URI: http://eprints.soton.ac.uk/id/eprint/417401
ISSN: 0264-410X
PURE UUID: 3228dac0-ace8-4613-8643-5debc56f8231
ORCID for Robert C. Read: ORCID iD orcid.org/0000-0002-4297-6728

Catalogue record

Date deposited: 30 Jan 2018 17:31
Last modified: 26 Nov 2021 02:58

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Contributors

Author: Robert C. Read ORCID iD
Author: Simone C. Naylor
Author: Christopher W. Potter
Author: Jenny Bond
Author: Inderjit Jabbal-Gill
Author: Anthony Fisher
Author: Lisbeth Illum
Author: Roy Jennings

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