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Preservation of nuclear spin order by precipitation

Preservation of nuclear spin order by precipitation
Preservation of nuclear spin order by precipitation
We demonstrate that non-equilibrium nuclear spin order survives precipitation from solution and redissolution. The effect is demonstrated on 13C- and 2H-labeled sodium fumarate, with precipitation and dissolution achieved by altering the pH. The lifetime of the spin magnetization in the precipitate suspension is found to be much longer than in solution. Our preliminary results show an extension of the effective relaxation time T1 for the metabolite fumarate by a factor of ≈6. We show that when the free radical agent TEMPO is present in the solution, it is not incorporated into the precipitate, suggesting that this procedure may provide a means to store and transport agents polarized by dynamic nuclear polarization. Although the relaxation time, T1, of the precipitate suspension is longer than that of the same molecules in solution, it is significantly shorter than that observed in the immobilized solid state.
1439-4235
40–44
Eills, James
23130b21-68fa-4c8b-9399-e55f2e71ef36
Alonso-Valdesueiro, Javier
ee87ede4-2a13-4e6e-af22-bda1d4c83517
Salazar Marcano, David E.
2d352f7d-9de0-4b38-88d3-c6eed7a29e85
Ferreira da Silva, Jesse
53724662-c835-4e07-b461-e555cad4f40b
Alom, Shamim
f6b56fb1-7f94-432a-87cd-887f6e5d9f64
Rees, Gregory J.
2a9e69dd-adf4-4c26-8e53-86d3c7f64397
Hanna, John V.
20ab8960-4ac0-41c7-bc4a-a40195717a51
Carravetta, Marina
1b12fa96-4a6a-4689-ab3b-ccc68f1d7691
Levitt, Malcolm H.
bcc5a80a-e5c5-4e0e-9a9a-249d036747c3
Eills, James
23130b21-68fa-4c8b-9399-e55f2e71ef36
Alonso-Valdesueiro, Javier
ee87ede4-2a13-4e6e-af22-bda1d4c83517
Salazar Marcano, David E.
2d352f7d-9de0-4b38-88d3-c6eed7a29e85
Ferreira da Silva, Jesse
53724662-c835-4e07-b461-e555cad4f40b
Alom, Shamim
f6b56fb1-7f94-432a-87cd-887f6e5d9f64
Rees, Gregory J.
2a9e69dd-adf4-4c26-8e53-86d3c7f64397
Hanna, John V.
20ab8960-4ac0-41c7-bc4a-a40195717a51
Carravetta, Marina
1b12fa96-4a6a-4689-ab3b-ccc68f1d7691
Levitt, Malcolm H.
bcc5a80a-e5c5-4e0e-9a9a-249d036747c3

Eills, James, Alonso-Valdesueiro, Javier, Salazar Marcano, David E., Ferreira da Silva, Jesse, Alom, Shamim, Rees, Gregory J., Hanna, John V., Carravetta, Marina and Levitt, Malcolm H. (2018) Preservation of nuclear spin order by precipitation. Chemphyschem, 19 (1), 40–44. (doi:10.1002/cphc.201701189).

Record type: Article

Abstract

We demonstrate that non-equilibrium nuclear spin order survives precipitation from solution and redissolution. The effect is demonstrated on 13C- and 2H-labeled sodium fumarate, with precipitation and dissolution achieved by altering the pH. The lifetime of the spin magnetization in the precipitate suspension is found to be much longer than in solution. Our preliminary results show an extension of the effective relaxation time T1 for the metabolite fumarate by a factor of ≈6. We show that when the free radical agent TEMPO is present in the solution, it is not incorporated into the precipitate, suggesting that this procedure may provide a means to store and transport agents polarized by dynamic nuclear polarization. Although the relaxation time, T1, of the precipitate suspension is longer than that of the same molecules in solution, it is significantly shorter than that observed in the immobilized solid state.

Text Eills_et_al._accepted - Accepted Manuscript
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Text Eills_et_al-2017-ChemPhysChem (1) - Version of Record
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More information

Accepted/In Press date: 2 November 2017
e-pub ahead of print date: 27 November 2017
Published date: 5 January 2018

Identifiers

Local EPrints ID: 417470
URI: https://eprints.soton.ac.uk/id/eprint/417470
ISSN: 1439-4235
PURE UUID: 184edc5f-085b-4a3e-ae55-8016b42fe69f
ORCID for Marina Carravetta: ORCID iD orcid.org/0000-0002-6296-2104
ORCID for Malcolm H. Levitt: ORCID iD orcid.org/0000-0001-9878-1180

Catalogue record

Date deposited: 31 Jan 2018 17:30
Last modified: 14 Jul 2018 00:34

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