Hypercalcaemia secondary to ectopic parathyroid hormone expression in an adolescent with metastatic alveolar rhabdomyosarcoma
Hypercalcaemia secondary to ectopic parathyroid hormone expression in an adolescent with metastatic alveolar rhabdomyosarcoma
We report the case of a 14-year-old male with metastatic alveolar rhabdomyosarcoma, presenting with hypercalcaemia (3.89 mmol/l) and elevated parathyroid hormone (PTH) level (10.2 pmol/l). Imaging demonstrated extensive bony lytic damage, with “floating teeth” in the mandible. Normalisation of calcium levels and bony reformation of the mandible occurred following chemotherapy; PTH levels decreased initially but remained above normal levels. Imaging did not demonstrate any evidence of parathyroid abnormality. Tumour ectopic PTH secretion is a very rare cause of hypercalcaemia of malignancy in children. Hypercalcaemia with an elevated PTH, in the absence of parathyroid-related cause, should prompt investigation for underlying malignancy.
alveolar rhabdomyosarcoma, ectopic parathyroid hormone, hypercalcaemia
Brooks, Rachael
0124a3e0-152c-4d86-8276-780141dbb1e9
Lord, Christopher
ef9354fa-36c0-475b-a777-f8ab88a44cbf
Davies, Justin H.
9f18fcad-f488-4c72-ac23-c154995443a9
Gray, Juliet C.
12d5e17c-97bb-4d6d-8fc4-3914b730ed42
1 January 2018
Brooks, Rachael
0124a3e0-152c-4d86-8276-780141dbb1e9
Lord, Christopher
ef9354fa-36c0-475b-a777-f8ab88a44cbf
Davies, Justin H.
9f18fcad-f488-4c72-ac23-c154995443a9
Gray, Juliet C.
12d5e17c-97bb-4d6d-8fc4-3914b730ed42
Brooks, Rachael, Lord, Christopher, Davies, Justin H. and Gray, Juliet C.
(2018)
Hypercalcaemia secondary to ectopic parathyroid hormone expression in an adolescent with metastatic alveolar rhabdomyosarcoma.
Pediatric Blood and Cancer, 65 (1), [e26778].
(doi:10.1002/pbc.26778).
Abstract
We report the case of a 14-year-old male with metastatic alveolar rhabdomyosarcoma, presenting with hypercalcaemia (3.89 mmol/l) and elevated parathyroid hormone (PTH) level (10.2 pmol/l). Imaging demonstrated extensive bony lytic damage, with “floating teeth” in the mandible. Normalisation of calcium levels and bony reformation of the mandible occurred following chemotherapy; PTH levels decreased initially but remained above normal levels. Imaging did not demonstrate any evidence of parathyroid abnormality. Tumour ectopic PTH secretion is a very rare cause of hypercalcaemia of malignancy in children. Hypercalcaemia with an elevated PTH, in the absence of parathyroid-related cause, should prompt investigation for underlying malignancy.
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Accepted/In Press date: 31 July 2017
e-pub ahead of print date: 26 August 2017
Published date: 1 January 2018
Keywords:
alveolar rhabdomyosarcoma, ectopic parathyroid hormone, hypercalcaemia
Identifiers
Local EPrints ID: 417493
URI: http://eprints.soton.ac.uk/id/eprint/417493
ISSN: 1545-5009
PURE UUID: 112d85fe-f931-416b-8e6e-67b62ca98db2
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Date deposited: 01 Feb 2018 17:30
Last modified: 16 Mar 2024 03:33
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Author:
Rachael Brooks
Author:
Christopher Lord
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