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Hypercalcaemia secondary to ectopic parathyroid hormone expression in an adolescent with metastatic alveolar rhabdomyosarcoma

Hypercalcaemia secondary to ectopic parathyroid hormone expression in an adolescent with metastatic alveolar rhabdomyosarcoma
Hypercalcaemia secondary to ectopic parathyroid hormone expression in an adolescent with metastatic alveolar rhabdomyosarcoma

We report the case of a 14-year-old male with metastatic alveolar rhabdomyosarcoma, presenting with hypercalcaemia (3.89 mmol/l) and elevated parathyroid hormone (PTH) level (10.2 pmol/l). Imaging demonstrated extensive bony lytic damage, with “floating teeth” in the mandible. Normalisation of calcium levels and bony reformation of the mandible occurred following chemotherapy; PTH levels decreased initially but remained above normal levels. Imaging did not demonstrate any evidence of parathyroid abnormality. Tumour ectopic PTH secretion is a very rare cause of hypercalcaemia of malignancy in children. Hypercalcaemia with an elevated PTH, in the absence of parathyroid-related cause, should prompt investigation for underlying malignancy.

alveolar rhabdomyosarcoma, ectopic parathyroid hormone, hypercalcaemia
1545-5009
Brooks, Rachael
0124a3e0-152c-4d86-8276-780141dbb1e9
Lord, Christopher
ef9354fa-36c0-475b-a777-f8ab88a44cbf
Davies, Justin H.
9f18fcad-f488-4c72-ac23-c154995443a9
Gray, Juliet C.
12d5e17c-97bb-4d6d-8fc4-3914b730ed42
Brooks, Rachael
0124a3e0-152c-4d86-8276-780141dbb1e9
Lord, Christopher
ef9354fa-36c0-475b-a777-f8ab88a44cbf
Davies, Justin H.
9f18fcad-f488-4c72-ac23-c154995443a9
Gray, Juliet C.
12d5e17c-97bb-4d6d-8fc4-3914b730ed42

Brooks, Rachael, Lord, Christopher, Davies, Justin H. and Gray, Juliet C. (2018) Hypercalcaemia secondary to ectopic parathyroid hormone expression in an adolescent with metastatic alveolar rhabdomyosarcoma Pediatric Blood and Cancer, 65, (1) (doi:10.1002/pbc.26778).

Record type: Article

Abstract

We report the case of a 14-year-old male with metastatic alveolar rhabdomyosarcoma, presenting with hypercalcaemia (3.89 mmol/l) and elevated parathyroid hormone (PTH) level (10.2 pmol/l). Imaging demonstrated extensive bony lytic damage, with “floating teeth” in the mandible. Normalisation of calcium levels and bony reformation of the mandible occurred following chemotherapy; PTH levels decreased initially but remained above normal levels. Imaging did not demonstrate any evidence of parathyroid abnormality. Tumour ectopic PTH secretion is a very rare cause of hypercalcaemia of malignancy in children. Hypercalcaemia with an elevated PTH, in the absence of parathyroid-related cause, should prompt investigation for underlying malignancy.

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More information

Accepted/In Press date: 31 July 2017
e-pub ahead of print date: 26 August 2017
Published date: 1 January 2018
Keywords: alveolar rhabdomyosarcoma, ectopic parathyroid hormone, hypercalcaemia

Identifiers

Local EPrints ID: 417493
URI: https://eprints.soton.ac.uk/id/eprint/417493
ISSN: 1545-5009
PURE UUID: 112d85fe-f931-416b-8e6e-67b62ca98db2

Catalogue record

Date deposited: 01 Feb 2018 17:30
Last modified: 22 Feb 2018 17:31

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