Ultraviolet B-induced maturation of CD11b-Type Langerin² dendritic cells controls the expansion of foxp3⁺ regulatory t cells in the skin

Yamazaki, Sayuri, Odanaka, Mizuyu, Nishioka, Akiko, Kasuya, Saori, Shime, Hiroaki, Hemmi, Hiroaki, Imai, Masaki, Riethmacher, Dieter, Kaisho, Tsuneyasu, Ohkura, Naganari, Sakaguchi, Shimon and Morita, Akimichi (2018) Ultraviolet B-induced maturation of CD11b-Type Langerin² dendritic cells controls the expansion of foxp3⁺ regulatory t cells in the skin. Journal of Immunology, 200 (1), 119-129. (doi:10.4049/jimmunol.1701056).

Abstract

Skin dendritic cells (DCs) are divided into several subsets with distinctive functions. This study shows a previously unappreciated role of dermal CD11b-type Langerin² DCs in maintaining immunological self-tolerance after UVB exposure. After UVB exposure, dermal CD11b-type Langerin² DCs upregulated surface CD86 expression, induced proliferation of Foxp3⁺ regulatory T (Treg) cells without exogenous Ags, and upregulated a set of genes associated with immunological tolerance. This Treg-expansion activity was significantly hampered by CD80/CD86 blockade in vivo. These results indicate that CD11b-type Langerin² DCs from the UVB-exposed skin are specialized to expand Treg cells in the skin, which suppress autoimmunity.

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Contributors

Author: Dieter Riethmacher

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