The University of Southampton
University of Southampton Institutional Repository

Prostate-specific antigen velocity in a prospective prostate cancer screening study of men with genetic predisposition

Prostate-specific antigen velocity in a prospective prostate cancer screening study of men with genetic predisposition
Prostate-specific antigen velocity in a prospective prostate cancer screening study of men with genetic predisposition
Background:

Prostate-specific antigen (PSA) and PSA-velocity (PSAV) have been used to identify men at risk of prostate cancer (PrCa). The IMPACT study is evaluating PSA screening in men with a known genetic predisposition to PrCa due to BRCA1/2 mutations. This analysis evaluates the utility of PSA and PSAV for identifying PrCa and high-grade disease in this cohort.

Methods:

PSAV was calculated using logistic regression to determine if PSA or PSAV predicted the result of prostate biopsy (PB) in men with elevated PSA values. Cox regression was used to determine whether PSA or PSAV predicted PSA elevation in men with low PSAs. Interaction terms were included in the models to determine whether BRCA status influenced the predictiveness of PSA or PSAV.

Results:

1634 participants had ⩾3 PSA readings of whom 174 underwent PB and 45 PrCas diagnosed. In men with PSA >3.0 ng ml−l, PSAV was not significantly associated with presence of cancer or high-grade disease. PSAV did not add to PSA for predicting time to an elevated PSA. When comparing BRCA1/2 carriers to non-carriers, we found a significant interaction between BRCA status and last PSA before biopsy (P=0.031) and BRCA2 status and PSAV (P=0.024). However, PSAV was not predictive of biopsy outcome in BRCA2 carriers.

Conclusions:

PSA is more strongly predictive of PrCa in BRCA carriers than non-carriers. We did not find evidence that PSAV aids decision-making for BRCA carriers over absolute PSA value alone.

0007-0920
266-276
Mikropoulos, Christos
8da9c89b-e707-472b-9270-de1ecf3ea557
Selkirk, Christina G.Hutten
9d3836a5-eff3-472e-95d9-aec4f38e27a7
Saya, Sibel
6eed0054-4fe3-4af6-9b83-1d92f3675197
Bancroft, Elizabeth
3b9eca84-7e95-4db7-b68f-43a69d70c3b6
Vertosick, Emily
23aa8973-57dd-4370-9032-ddf647f79f59
Dadaev, Tokhir
94476e01-4512-4955-aa99-dca12a490806
Brendler, Charles
94feda4e-78a0-4514-ace8-e84d040adf01
Page, Elizabeth
7e14b568-da27-48c8-b20f-c4388bc75365
Dias, Alexander
23e13ce6-e08b-4e22-a471-74ccb5754fe3
Evans, D. Gareth
314acefb-89fb-4eb7-a0e7-0a6949c9af6c
Rothwell, Jeanette
a67ca687-9b0a-4c44-add2-5d5038b8f0be
Maehle, Lovise
d36d3d47-c751-4744-bc73-d82fd6bf47d4
Axcrona, Karol
9c49fa22-5562-408c-8faf-16166613891d
Richardson, Kate
f7d3fa93-d183-4775-8aa4-13cc12653c18
Eccles, Diana
5b59bc73-11c9-4cf0-a9d5-7a8e523eee23
Jensen, Thomas
a2352049-ccd1-4785-a9a8-b3822b8e82eb
Osther, Palle J.
1f11ae5c-6f1d-4f8d-bc1c-471798ed4bba
Van Asperen, Christi J.
126d1936-de55-443e-9f88-889d5252a4eb
Vasen, Hans
f06afc40-a2e3-4033-a881-662b3934878f
Kiemeney, Lambertus A.
a6af871e-f8d5-4a1f-a114-842b0f2a88e2
Ringelberg, Janneke
83e32404-fd90-4854-95c4-4d279905ffd4
Cybulski, Cezary
6c6cf54d-5e0e-4395-b8bb-7f1691a90e7f
Wokolorczyk, Dominika
f5486ac7-451b-4fc0-b4ab-fd3f1f0dfcf5
Hart, Rachel
d94da143-77ec-4dbc-8abd-a8f1d84b3d51
Glover, Wayne
48fa6019-759c-4cca-83f1-223ef419be91
Lam, Jimmy
3719041b-01f5-4821-94ea-5b173bf4356f
Taylor, Louise
ccba1810-76b9-403e-8212-37983539afac
Salinas, Monica
6c801b51-e3b4-4153-a192-9127c2fdefc7
Feliubadaló, Lidia
a4645fea-e41b-4cf3-96b9-00cfe8becefe
Oldenburg, Rogier
b12d0328-2535-49e9-ab89-721e013d2c0a
Cremers, Ruben
0f3ba54e-2a2f-4ea3-b3ec-91fedc053acd
Verhaegh, Gerald
b285e260-5e99-42f2-bea8-e702dc788bb4
Van Zelst-Stams, Wendy A.
eecc135f-e73a-4c10-a57b-9327ea592ef4
Oosterwijk, Jan C.
281f3aba-7b6a-4ce5-a1c6-a71194155181
Cook, Jackie
b24e3336-f47a-4590-bc3f-7e2ab7d78e0d
Rosario, Derek J.
692789e4-89a4-4d0d-9cbb-94473a1765c4
Buys, Saundra S.
afc30830-c4ff-43ee-b6cd-9ec8eb6fa052
Conner, Tom
7d06bbdc-f408-41af-b2cd-bd310a000681
Domchek, Susan
df50a114-d9f2-4796-934d-6344bbac5637
Powers, Jacquelyn
f95649f0-f2af-452a-91d9-9cb856b5c8a5
Ausems, Margreet Gem
e7a4b7e9-0039-4aeb-bc0d-c48d902e388d
Teixeira, Manuel R.
bc0e9fc9-4f2f-4c30-a6ca-9c3a5e40a3bc
Maia, Sofia
1684dd26-26ad-4987-8c62-6f8023d8d8bb
Izatt, Louise
5d6201a8-8a56-4923-ac9d-75dca6be0a40
Schmutzler, Rita
f2db338c-096b-4e95-bfb3-ff2602117ea5
Rhiem, Kerstin
5fbe374e-0810-4da0-a4fa-3e311fa952d7
Foulkes, William D.
86f8fdac-c1e5-41d2-87f0-fc0eb7977b6e
Boshari, Talia
36094a99-a0d0-4e2a-8ff7-9b80e13f4e58
Davidson, Rosemarie
81692cd9-0a70-4a01-a68f-8eb623f0fbe0
Ruijs, Marielle
cd73ee2f-1df8-49a3-85f6-45f4a6232a23
Helderman-Van Den Enden, Apollonia Tjm
b3472170-cb01-4e6f-86c7-62154bf3daf6
Andrews, Lesley
ca8071e2-d653-448a-97d6-7a0ce6ffcd7f
Walker, Lisa
682b9d2c-3469-416e-b9dc-a5c68626fba7
Snape, Katie
bfd0af55-1a6d-41d0-aad6-2b3b0b4c73e2
Henderson, Alex
fc45580d-3aa1-4f4f-98f6-dc0ea809ac2f
Jobson, Irene
4099836e-9e46-4463-94f6-6411f56c92cc
Lindeman, Geoffrey J.
4bc92f9c-f152-4cf2-87f5-0d4efc62166a
Liljegren, Annelie
2bb446db-228b-4e61-91cc-655d47196ac1
Harris, Marion
678a742e-dfbe-45aa-806c-9154147857ba
Adank, Muriel A.
d2d60f0a-ef7b-4f1e-82e3-b879249bf920
Kirk, Judy
face1434-33b8-44b1-a342-e9a394c75281
Taylor, Amy
a9782022-0291-4d7b-947a-824e0ed3762c
Susman, Rachel
9b6e2a11-08dc-4a4d-831f-351dcaa74683
Chen-Shtoyerman, Rakefet
fef0592e-be75-4a48-aed0-091f85e9392f
Pachter, Nicholas
83e90843-a470-43a2-a60c-9b898e750287
Spigelman, Allan
6f1ad6b1-3d43-4623-a318-6c2459315a64
Side, Lucy
197fd9f8-2bd8-4e7e-b46f-4a87df3f20d2
Zgajnar, Janez
32094a66-fa7a-46fb-b6f1-5dd8eaa64990
Mora, Josefina
e504bdd3-1465-469f-8892-f6b7c439872c
Brewer, Carole
f497c7f3-050d-4494-aecb-7e6a23101d18
Gadea, Neus
59d9ee72-1148-4f11-af6c-d2a92dc470e4
Brady, Angela F.
6a592734-d3ec-40dd-a159-f157cd8f56eb
Gallagher, David
30784cbc-6c0b-4bd7-b2ec-47caf8a8fd25
Van Os, Theo
bafeac3f-4b03-425f-a19d-9e10d7e837cf
Donaldson, Alan
8bd5454f-be4c-4b7a-ae31-c602f391920e
Stefansdottir, Vigdis
6e0f9725-c096-4cc5-bc8a-07c1c8df5286
Barwell, Julian
775206d7-77c1-46bb-a6ff-932204a3c2f5
James, Paul A.
9fb2dc20-8439-4f29-9587-72caa150f0f9
Murphy, Declan
e9bd7d40-a8fd-4732-abfe-f8a9dae34a7f
Friedman, Eitan
764d4102-31ee-4826-ad68-0da74dba88f2
Nicolai, Nicola
d5f1b7a2-19e0-443f-8dfb-7ab122bd1010
Greenhalgh, Lynn
c763cce9-4b01-453d-8975-2a7390a8beaa
Obeid, Elias
bd285a04-9236-4a2a-8dc9-de70690aca74
Murthy, Vedang
a5a4b39a-bfc3-43ad-aa2c-e8b151bb9fdc
Copakova, Lucia
ac141946-7066-4424-8447-e4fc2e433cc8
McGrath, John
4854f383-9346-4ffa-a1d7-4aedc3b5ce29
Teo, Soo Hwang
f48023c5-9e80-487b-83c7-f09563a9579d
Strom, Sara
739ce0d8-eca1-4229-892e-4f1a6ac05bf1
Kast, Karin
7cde00f5-f897-4c84-bb86-2ecdd6e23b6d
Leongamornlert, Daniel A.
139db594-d5e3-4765-9e00-539798fbab09
Chamberlain, Anthony
46300b12-7190-4468-b9f1-8d6024fb9d0b
Pope, Jenny
ab3723d8-6238-4a21-8e74-80b4c9263906
Newlin, Anna C.
a435907c-3bc4-4b93-89a9-1fb470285813
Aaronson, Neil
621af15d-8045-42c9-a803-49273f941079
Ardern-Jones, Audrey
312b76d6-ceac-49a7-b3ef-1b04688686f3
Bangma, Chris
9e224fa7-6b4d-46b6-86b2-817bc6966fb9
Castro, Elena
c7e21bea-2fec-4682-b744-051720d4a6ce
Dearnaley, David
9254156f-ba5e-4d15-8522-0f0d00b07584
Eyfjord, Jorunn
ef819853-3020-42ac-a273-5b9f6df74e55
Falconer, Alison
0a4fbe1a-def8-4bb2-8d09-2e8b86d4233b
Foster, Christopher S.
849411da-44cf-4cf4-a479-b34844c2dcba
Gronberg, Henrik
2fd55a37-b19b-48c3-885f-da70c1b4735c
Hamdy, Freddie C.
b4c01384-52e7-432e-816a-57f2bc50215d
Johannsson, Oskar
e50b7b3b-1562-4ce9-9c4b-7f1ca784f9ec
Khoo, Vincent
d650b6bc-1490-439c-9ee1-e1e657b81d24
Lubinski, Jan
e7a9709c-36b3-44ed-a5e0-675177ca3d51
Grindedal, Eli Marie
9e052052-e4d3-42c3-ae08-7378781d8707
McKinley, Joanne
3d15a8c2-2fcc-40b0-959e-9a81d21352f2
Shackleton, Kylie
c6a41f07-fef8-4528-9e7a-acce538aec17
Mitra, Anita V.
dda5ffa5-fa8e-444d-9bdb-07fd1cfbb120
Moynihan, Clare
5830406c-b68c-4ec6-ac83-833c2af9b095
Rennert, Gad
76f7951d-133b-4b7e-86a2-175be20d775d
Suri, Mohnish
bb44c6fb-9bfd-4bd5-a187-b245c17bbd6f
Tricker, Karen
85523ce4-f7b4-4f67-bd6c-2adec2ff2695
Moss, Sue
27396331-96bc-49cf-9243-e46025fc701b
Kote-Jarai, Zsofia
c5b0a417-48b3-4cd4-a242-8fad3f4d4bf6
Vickers, Andrew
5bc6f722-6eb7-4136-84ef-a75d5e7e3df7
Lilja, Hans
784c879d-cba0-456a-8bbc-a08b5ed687ac
Helfand, Brian T.
c65e6e24-00a8-45bd-b09b-1e46a33c2f9b
Eeles, Rosalind A.
b11a81ed-c0fc-4edc-a3b9-bbc300f19576
Mikropoulos, Christos
8da9c89b-e707-472b-9270-de1ecf3ea557
Selkirk, Christina G.Hutten
9d3836a5-eff3-472e-95d9-aec4f38e27a7
Saya, Sibel
6eed0054-4fe3-4af6-9b83-1d92f3675197
Bancroft, Elizabeth
3b9eca84-7e95-4db7-b68f-43a69d70c3b6
Vertosick, Emily
23aa8973-57dd-4370-9032-ddf647f79f59
Dadaev, Tokhir
94476e01-4512-4955-aa99-dca12a490806
Brendler, Charles
94feda4e-78a0-4514-ace8-e84d040adf01
Page, Elizabeth
7e14b568-da27-48c8-b20f-c4388bc75365
Dias, Alexander
23e13ce6-e08b-4e22-a471-74ccb5754fe3
Evans, D. Gareth
314acefb-89fb-4eb7-a0e7-0a6949c9af6c
Rothwell, Jeanette
a67ca687-9b0a-4c44-add2-5d5038b8f0be
Maehle, Lovise
d36d3d47-c751-4744-bc73-d82fd6bf47d4
Axcrona, Karol
9c49fa22-5562-408c-8faf-16166613891d
Richardson, Kate
f7d3fa93-d183-4775-8aa4-13cc12653c18
Eccles, Diana
5b59bc73-11c9-4cf0-a9d5-7a8e523eee23
Jensen, Thomas
a2352049-ccd1-4785-a9a8-b3822b8e82eb
Osther, Palle J.
1f11ae5c-6f1d-4f8d-bc1c-471798ed4bba
Van Asperen, Christi J.
126d1936-de55-443e-9f88-889d5252a4eb
Vasen, Hans
f06afc40-a2e3-4033-a881-662b3934878f
Kiemeney, Lambertus A.
a6af871e-f8d5-4a1f-a114-842b0f2a88e2
Ringelberg, Janneke
83e32404-fd90-4854-95c4-4d279905ffd4
Cybulski, Cezary
6c6cf54d-5e0e-4395-b8bb-7f1691a90e7f
Wokolorczyk, Dominika
f5486ac7-451b-4fc0-b4ab-fd3f1f0dfcf5
Hart, Rachel
d94da143-77ec-4dbc-8abd-a8f1d84b3d51
Glover, Wayne
48fa6019-759c-4cca-83f1-223ef419be91
Lam, Jimmy
3719041b-01f5-4821-94ea-5b173bf4356f
Taylor, Louise
ccba1810-76b9-403e-8212-37983539afac
Salinas, Monica
6c801b51-e3b4-4153-a192-9127c2fdefc7
Feliubadaló, Lidia
a4645fea-e41b-4cf3-96b9-00cfe8becefe
Oldenburg, Rogier
b12d0328-2535-49e9-ab89-721e013d2c0a
Cremers, Ruben
0f3ba54e-2a2f-4ea3-b3ec-91fedc053acd
Verhaegh, Gerald
b285e260-5e99-42f2-bea8-e702dc788bb4
Van Zelst-Stams, Wendy A.
eecc135f-e73a-4c10-a57b-9327ea592ef4
Oosterwijk, Jan C.
281f3aba-7b6a-4ce5-a1c6-a71194155181
Cook, Jackie
b24e3336-f47a-4590-bc3f-7e2ab7d78e0d
Rosario, Derek J.
692789e4-89a4-4d0d-9cbb-94473a1765c4
Buys, Saundra S.
afc30830-c4ff-43ee-b6cd-9ec8eb6fa052
Conner, Tom
7d06bbdc-f408-41af-b2cd-bd310a000681
Domchek, Susan
df50a114-d9f2-4796-934d-6344bbac5637
Powers, Jacquelyn
f95649f0-f2af-452a-91d9-9cb856b5c8a5
Ausems, Margreet Gem
e7a4b7e9-0039-4aeb-bc0d-c48d902e388d
Teixeira, Manuel R.
bc0e9fc9-4f2f-4c30-a6ca-9c3a5e40a3bc
Maia, Sofia
1684dd26-26ad-4987-8c62-6f8023d8d8bb
Izatt, Louise
5d6201a8-8a56-4923-ac9d-75dca6be0a40
Schmutzler, Rita
f2db338c-096b-4e95-bfb3-ff2602117ea5
Rhiem, Kerstin
5fbe374e-0810-4da0-a4fa-3e311fa952d7
Foulkes, William D.
86f8fdac-c1e5-41d2-87f0-fc0eb7977b6e
Boshari, Talia
36094a99-a0d0-4e2a-8ff7-9b80e13f4e58
Davidson, Rosemarie
81692cd9-0a70-4a01-a68f-8eb623f0fbe0
Ruijs, Marielle
cd73ee2f-1df8-49a3-85f6-45f4a6232a23
Helderman-Van Den Enden, Apollonia Tjm
b3472170-cb01-4e6f-86c7-62154bf3daf6
Andrews, Lesley
ca8071e2-d653-448a-97d6-7a0ce6ffcd7f
Walker, Lisa
682b9d2c-3469-416e-b9dc-a5c68626fba7
Snape, Katie
bfd0af55-1a6d-41d0-aad6-2b3b0b4c73e2
Henderson, Alex
fc45580d-3aa1-4f4f-98f6-dc0ea809ac2f
Jobson, Irene
4099836e-9e46-4463-94f6-6411f56c92cc
Lindeman, Geoffrey J.
4bc92f9c-f152-4cf2-87f5-0d4efc62166a
Liljegren, Annelie
2bb446db-228b-4e61-91cc-655d47196ac1
Harris, Marion
678a742e-dfbe-45aa-806c-9154147857ba
Adank, Muriel A.
d2d60f0a-ef7b-4f1e-82e3-b879249bf920
Kirk, Judy
face1434-33b8-44b1-a342-e9a394c75281
Taylor, Amy
a9782022-0291-4d7b-947a-824e0ed3762c
Susman, Rachel
9b6e2a11-08dc-4a4d-831f-351dcaa74683
Chen-Shtoyerman, Rakefet
fef0592e-be75-4a48-aed0-091f85e9392f
Pachter, Nicholas
83e90843-a470-43a2-a60c-9b898e750287
Spigelman, Allan
6f1ad6b1-3d43-4623-a318-6c2459315a64
Side, Lucy
197fd9f8-2bd8-4e7e-b46f-4a87df3f20d2
Zgajnar, Janez
32094a66-fa7a-46fb-b6f1-5dd8eaa64990
Mora, Josefina
e504bdd3-1465-469f-8892-f6b7c439872c
Brewer, Carole
f497c7f3-050d-4494-aecb-7e6a23101d18
Gadea, Neus
59d9ee72-1148-4f11-af6c-d2a92dc470e4
Brady, Angela F.
6a592734-d3ec-40dd-a159-f157cd8f56eb
Gallagher, David
30784cbc-6c0b-4bd7-b2ec-47caf8a8fd25
Van Os, Theo
bafeac3f-4b03-425f-a19d-9e10d7e837cf
Donaldson, Alan
8bd5454f-be4c-4b7a-ae31-c602f391920e
Stefansdottir, Vigdis
6e0f9725-c096-4cc5-bc8a-07c1c8df5286
Barwell, Julian
775206d7-77c1-46bb-a6ff-932204a3c2f5
James, Paul A.
9fb2dc20-8439-4f29-9587-72caa150f0f9
Murphy, Declan
e9bd7d40-a8fd-4732-abfe-f8a9dae34a7f
Friedman, Eitan
764d4102-31ee-4826-ad68-0da74dba88f2
Nicolai, Nicola
d5f1b7a2-19e0-443f-8dfb-7ab122bd1010
Greenhalgh, Lynn
c763cce9-4b01-453d-8975-2a7390a8beaa
Obeid, Elias
bd285a04-9236-4a2a-8dc9-de70690aca74
Murthy, Vedang
a5a4b39a-bfc3-43ad-aa2c-e8b151bb9fdc
Copakova, Lucia
ac141946-7066-4424-8447-e4fc2e433cc8
McGrath, John
4854f383-9346-4ffa-a1d7-4aedc3b5ce29
Teo, Soo Hwang
f48023c5-9e80-487b-83c7-f09563a9579d
Strom, Sara
739ce0d8-eca1-4229-892e-4f1a6ac05bf1
Kast, Karin
7cde00f5-f897-4c84-bb86-2ecdd6e23b6d
Leongamornlert, Daniel A.
139db594-d5e3-4765-9e00-539798fbab09
Chamberlain, Anthony
46300b12-7190-4468-b9f1-8d6024fb9d0b
Pope, Jenny
ab3723d8-6238-4a21-8e74-80b4c9263906
Newlin, Anna C.
a435907c-3bc4-4b93-89a9-1fb470285813
Aaronson, Neil
621af15d-8045-42c9-a803-49273f941079
Ardern-Jones, Audrey
312b76d6-ceac-49a7-b3ef-1b04688686f3
Bangma, Chris
9e224fa7-6b4d-46b6-86b2-817bc6966fb9
Castro, Elena
c7e21bea-2fec-4682-b744-051720d4a6ce
Dearnaley, David
9254156f-ba5e-4d15-8522-0f0d00b07584
Eyfjord, Jorunn
ef819853-3020-42ac-a273-5b9f6df74e55
Falconer, Alison
0a4fbe1a-def8-4bb2-8d09-2e8b86d4233b
Foster, Christopher S.
849411da-44cf-4cf4-a479-b34844c2dcba
Gronberg, Henrik
2fd55a37-b19b-48c3-885f-da70c1b4735c
Hamdy, Freddie C.
b4c01384-52e7-432e-816a-57f2bc50215d
Johannsson, Oskar
e50b7b3b-1562-4ce9-9c4b-7f1ca784f9ec
Khoo, Vincent
d650b6bc-1490-439c-9ee1-e1e657b81d24
Lubinski, Jan
e7a9709c-36b3-44ed-a5e0-675177ca3d51
Grindedal, Eli Marie
9e052052-e4d3-42c3-ae08-7378781d8707
McKinley, Joanne
3d15a8c2-2fcc-40b0-959e-9a81d21352f2
Shackleton, Kylie
c6a41f07-fef8-4528-9e7a-acce538aec17
Mitra, Anita V.
dda5ffa5-fa8e-444d-9bdb-07fd1cfbb120
Moynihan, Clare
5830406c-b68c-4ec6-ac83-833c2af9b095
Rennert, Gad
76f7951d-133b-4b7e-86a2-175be20d775d
Suri, Mohnish
bb44c6fb-9bfd-4bd5-a187-b245c17bbd6f
Tricker, Karen
85523ce4-f7b4-4f67-bd6c-2adec2ff2695
Moss, Sue
27396331-96bc-49cf-9243-e46025fc701b
Kote-Jarai, Zsofia
c5b0a417-48b3-4cd4-a242-8fad3f4d4bf6
Vickers, Andrew
5bc6f722-6eb7-4136-84ef-a75d5e7e3df7
Lilja, Hans
784c879d-cba0-456a-8bbc-a08b5ed687ac
Helfand, Brian T.
c65e6e24-00a8-45bd-b09b-1e46a33c2f9b
Eeles, Rosalind A.
b11a81ed-c0fc-4edc-a3b9-bbc300f19576

Mikropoulos, Christos, Selkirk, Christina G.Hutten, Saya, Sibel, Bancroft, Elizabeth, Vertosick, Emily, Dadaev, Tokhir, Brendler, Charles, Page, Elizabeth, Dias, Alexander, Evans, D. Gareth, Rothwell, Jeanette, Maehle, Lovise, Axcrona, Karol, Richardson, Kate, Eccles, Diana, Jensen, Thomas, Osther, Palle J., Van Asperen, Christi J., Vasen, Hans, Kiemeney, Lambertus A., Ringelberg, Janneke, Cybulski, Cezary, Wokolorczyk, Dominika, Hart, Rachel, Glover, Wayne, Lam, Jimmy, Taylor, Louise, Salinas, Monica, Feliubadaló, Lidia, Oldenburg, Rogier, Cremers, Ruben, Verhaegh, Gerald, Van Zelst-Stams, Wendy A., Oosterwijk, Jan C., Cook, Jackie, Rosario, Derek J., Buys, Saundra S., Conner, Tom, Domchek, Susan, Powers, Jacquelyn, Ausems, Margreet Gem, Teixeira, Manuel R., Maia, Sofia, Izatt, Louise, Schmutzler, Rita, Rhiem, Kerstin, Foulkes, William D., Boshari, Talia, Davidson, Rosemarie, Ruijs, Marielle, Helderman-Van Den Enden, Apollonia Tjm, Andrews, Lesley, Walker, Lisa, Snape, Katie, Henderson, Alex, Jobson, Irene, Lindeman, Geoffrey J., Liljegren, Annelie, Harris, Marion, Adank, Muriel A., Kirk, Judy, Taylor, Amy, Susman, Rachel, Chen-Shtoyerman, Rakefet, Pachter, Nicholas, Spigelman, Allan, Side, Lucy, Zgajnar, Janez, Mora, Josefina, Brewer, Carole, Gadea, Neus, Brady, Angela F., Gallagher, David, Van Os, Theo, Donaldson, Alan, Stefansdottir, Vigdis, Barwell, Julian, James, Paul A., Murphy, Declan, Friedman, Eitan, Nicolai, Nicola, Greenhalgh, Lynn, Obeid, Elias, Murthy, Vedang, Copakova, Lucia, McGrath, John, Teo, Soo Hwang, Strom, Sara, Kast, Karin, Leongamornlert, Daniel A., Chamberlain, Anthony, Pope, Jenny, Newlin, Anna C., Aaronson, Neil, Ardern-Jones, Audrey, Bangma, Chris, Castro, Elena, Dearnaley, David, Eyfjord, Jorunn, Falconer, Alison, Foster, Christopher S., Gronberg, Henrik, Hamdy, Freddie C., Johannsson, Oskar, Khoo, Vincent, Lubinski, Jan, Grindedal, Eli Marie, McKinley, Joanne, Shackleton, Kylie, Mitra, Anita V., Moynihan, Clare, Rennert, Gad, Suri, Mohnish, Tricker, Karen, Moss, Sue, Kote-Jarai, Zsofia, Vickers, Andrew, Lilja, Hans, Helfand, Brian T. and Eeles, Rosalind A. (2018) Prostate-specific antigen velocity in a prospective prostate cancer screening study of men with genetic predisposition. British Journal of Cancer, 118 (2), 266-276. (doi:10.1038/bjc.2017.429).

Record type: Article

Abstract

Background:

Prostate-specific antigen (PSA) and PSA-velocity (PSAV) have been used to identify men at risk of prostate cancer (PrCa). The IMPACT study is evaluating PSA screening in men with a known genetic predisposition to PrCa due to BRCA1/2 mutations. This analysis evaluates the utility of PSA and PSAV for identifying PrCa and high-grade disease in this cohort.

Methods:

PSAV was calculated using logistic regression to determine if PSA or PSAV predicted the result of prostate biopsy (PB) in men with elevated PSA values. Cox regression was used to determine whether PSA or PSAV predicted PSA elevation in men with low PSAs. Interaction terms were included in the models to determine whether BRCA status influenced the predictiveness of PSA or PSAV.

Results:

1634 participants had ⩾3 PSA readings of whom 174 underwent PB and 45 PrCas diagnosed. In men with PSA >3.0 ng ml−l, PSAV was not significantly associated with presence of cancer or high-grade disease. PSAV did not add to PSA for predicting time to an elevated PSA. When comparing BRCA1/2 carriers to non-carriers, we found a significant interaction between BRCA status and last PSA before biopsy (P=0.031) and BRCA2 status and PSAV (P=0.024). However, PSAV was not predictive of biopsy outcome in BRCA2 carriers.

Conclusions:

PSA is more strongly predictive of PrCa in BRCA carriers than non-carriers. We did not find evidence that PSAV aids decision-making for BRCA carriers over absolute PSA value alone.

Text bjc2017429 - Version of Record
Download (367kB)

More information

Accepted/In Press date: 6 November 2017
Published date: 1 January 2018

Identifiers

Local EPrints ID: 417589
URI: https://eprints.soton.ac.uk/id/eprint/417589
ISSN: 0007-0920
PURE UUID: a2587e52-2ba8-427b-8a40-257ce47a8853

Catalogue record

Date deposited: 06 Feb 2018 17:30
Last modified: 23 May 2018 16:31

Export record

Altmetrics

Contributors

Author: Christos Mikropoulos
Author: Christina G.Hutten Selkirk
Author: Sibel Saya
Author: Elizabeth Bancroft
Author: Emily Vertosick
Author: Tokhir Dadaev
Author: Charles Brendler
Author: Elizabeth Page
Author: Alexander Dias
Author: D. Gareth Evans
Author: Jeanette Rothwell
Author: Lovise Maehle
Author: Karol Axcrona
Author: Kate Richardson
Author: Diana Eccles
Author: Thomas Jensen
Author: Palle J. Osther
Author: Christi J. Van Asperen
Author: Hans Vasen
Author: Lambertus A. Kiemeney
Author: Janneke Ringelberg
Author: Cezary Cybulski
Author: Dominika Wokolorczyk
Author: Rachel Hart
Author: Wayne Glover
Author: Jimmy Lam
Author: Louise Taylor
Author: Monica Salinas
Author: Lidia Feliubadaló
Author: Rogier Oldenburg
Author: Ruben Cremers
Author: Gerald Verhaegh
Author: Wendy A. Van Zelst-Stams
Author: Jan C. Oosterwijk
Author: Jackie Cook
Author: Derek J. Rosario
Author: Saundra S. Buys
Author: Tom Conner
Author: Susan Domchek
Author: Jacquelyn Powers
Author: Margreet Gem Ausems
Author: Manuel R. Teixeira
Author: Sofia Maia
Author: Louise Izatt
Author: Rita Schmutzler
Author: Kerstin Rhiem
Author: William D. Foulkes
Author: Talia Boshari
Author: Rosemarie Davidson
Author: Marielle Ruijs
Author: Apollonia Tjm Helderman-Van Den Enden
Author: Lesley Andrews
Author: Lisa Walker
Author: Katie Snape
Author: Alex Henderson
Author: Irene Jobson
Author: Geoffrey J. Lindeman
Author: Annelie Liljegren
Author: Marion Harris
Author: Muriel A. Adank
Author: Judy Kirk
Author: Amy Taylor
Author: Rachel Susman
Author: Rakefet Chen-Shtoyerman
Author: Nicholas Pachter
Author: Allan Spigelman
Author: Lucy Side
Author: Janez Zgajnar
Author: Josefina Mora
Author: Carole Brewer
Author: Neus Gadea
Author: Angela F. Brady
Author: David Gallagher
Author: Theo Van Os
Author: Alan Donaldson
Author: Vigdis Stefansdottir
Author: Julian Barwell
Author: Paul A. James
Author: Declan Murphy
Author: Eitan Friedman
Author: Nicola Nicolai
Author: Lynn Greenhalgh
Author: Elias Obeid
Author: Vedang Murthy
Author: Lucia Copakova
Author: John McGrath
Author: Soo Hwang Teo
Author: Sara Strom
Author: Karin Kast
Author: Daniel A. Leongamornlert
Author: Anthony Chamberlain
Author: Jenny Pope
Author: Anna C. Newlin
Author: Neil Aaronson
Author: Audrey Ardern-Jones
Author: Chris Bangma
Author: Elena Castro
Author: David Dearnaley
Author: Jorunn Eyfjord
Author: Alison Falconer
Author: Christopher S. Foster
Author: Henrik Gronberg
Author: Freddie C. Hamdy
Author: Oskar Johannsson
Author: Vincent Khoo
Author: Jan Lubinski
Author: Eli Marie Grindedal
Author: Joanne McKinley
Author: Kylie Shackleton
Author: Anita V. Mitra
Author: Clare Moynihan
Author: Gad Rennert
Author: Mohnish Suri
Author: Karen Tricker
Author: Sue Moss
Author: Zsofia Kote-Jarai
Author: Andrew Vickers
Author: Hans Lilja
Author: Brian T. Helfand
Author: Rosalind A. Eeles

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of https://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×