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Fine-mapping of genetic loci driving spontaneous clearance of hepatitis C virus infection

Fine-mapping of genetic loci driving spontaneous clearance of hepatitis C virus infection
Fine-mapping of genetic loci driving spontaneous clearance of hepatitis C virus infection
Approximately three quarters of acute hepatitis C (HCV) infections evolve to a chronic state, while one quarter are spontaneously cleared. Genetic predispositions strongly contribute to the development of chronicity. We have conducted a genome-wide association study to identify genomic variants underlying HCV spontaneous clearance using ImmunoChip in European and African ancestries. We confirmed two previously reported significant associations, in the IL28B/IFNL4 and the major histocompatibility complex (MHC) regions, with spontaneous clearance in the European population. We further fine-mapped the association in the MHC to a region of about 50 kilo base pairs, down from 1 mega base pairs in the previous study. Additional analyses suggested that the association in MHC is stronger in samples from North America than those from Europe
2045-2322
1-9
Huang, Hailiang
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Duggal, Priya
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Thio, Chloe L.
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Latanich, Rachel
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Goedert, James J.
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Mangia, Alessandra
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Cox, Andrea L.
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Kirk, Gregory D.
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Mehta, Shruti
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Aneja, Jasneet
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Alric, Laurent
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Donfield, Sharyne M.
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Cramp, Matthew E.
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Khakoo, Salim
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Tobler, Leslie H.
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Busch, Michael
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Alexander, Graeme J.
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Rosen, Hugo R.
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Edlin, Brian R.
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Segal, Florencia P.
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Lauer, Georg M.
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Thomas, David L.
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Daly, Mark J.
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Chung, Raymond T.
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Kim, Arthur Y.
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Huang, Hailiang
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Duggal, Priya
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Thio, Chloe L.
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Latanich, Rachel
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Goedert, James J.
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Mangia, Alessandra
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Cox, Andrea L.
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Kirk, Gregory D.
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Mehta, Shruti
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Aneja, Jasneet
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Alric, Laurent
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Donfield, Sharyne M.
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Cramp, Matthew E.
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Khakoo, Salim
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Tobler, Leslie H.
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Busch, Michael
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Alexander, Graeme J.
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Rosen, Hugo R.
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Edlin, Brian R.
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Segal, Florencia P.
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Lauer, Georg M.
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Thomas, David L.
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Daly, Mark J.
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Chung, Raymond T.
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Kim, Arthur Y.
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Huang, Hailiang, Duggal, Priya, Thio, Chloe L., Latanich, Rachel, Goedert, James J., Mangia, Alessandra, Cox, Andrea L., Kirk, Gregory D., Mehta, Shruti, Aneja, Jasneet, Alric, Laurent, Donfield, Sharyne M., Cramp, Matthew E., Khakoo, Salim, Tobler, Leslie H., Busch, Michael, Alexander, Graeme J., Rosen, Hugo R., Edlin, Brian R., Segal, Florencia P., Lauer, Georg M., Thomas, David L., Daly, Mark J., Chung, Raymond T. and Kim, Arthur Y. (2017) Fine-mapping of genetic loci driving spontaneous clearance of hepatitis C virus infection. Scientific Reports, 7, 1-9, [15843]. (doi:10.1038/s41598-017-16011-2).

Record type: Article

Abstract

Approximately three quarters of acute hepatitis C (HCV) infections evolve to a chronic state, while one quarter are spontaneously cleared. Genetic predispositions strongly contribute to the development of chronicity. We have conducted a genome-wide association study to identify genomic variants underlying HCV spontaneous clearance using ImmunoChip in European and African ancestries. We confirmed two previously reported significant associations, in the IL28B/IFNL4 and the major histocompatibility complex (MHC) regions, with spontaneous clearance in the European population. We further fine-mapped the association in the MHC to a region of about 50 kilo base pairs, down from 1 mega base pairs in the previous study. Additional analyses suggested that the association in MHC is stronger in samples from North America than those from Europe

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s41598-017-16011-2 - Version of Record
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Accepted/In Press date: 6 November 2017
e-pub ahead of print date: 20 November 2017

Identifiers

Local EPrints ID: 417637
URI: http://eprints.soton.ac.uk/id/eprint/417637
ISSN: 2045-2322
PURE UUID: b66aed9f-6ca7-4a5f-a9bc-6f2e3627370e

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Date deposited: 08 Feb 2018 17:30
Last modified: 06 Oct 2020 22:34

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Contributors

Author: Hailiang Huang
Author: Priya Duggal
Author: Chloe L. Thio
Author: Rachel Latanich
Author: James J. Goedert
Author: Alessandra Mangia
Author: Andrea L. Cox
Author: Gregory D. Kirk
Author: Shruti Mehta
Author: Jasneet Aneja
Author: Laurent Alric
Author: Sharyne M. Donfield
Author: Matthew E. Cramp
Author: Salim Khakoo
Author: Leslie H. Tobler
Author: Michael Busch
Author: Graeme J. Alexander
Author: Hugo R. Rosen
Author: Brian R. Edlin
Author: Florencia P. Segal
Author: Georg M. Lauer
Author: David L. Thomas
Author: Mark J. Daly
Author: Raymond T. Chung
Author: Arthur Y. Kim

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