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Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives. Since the field continues to expand and novel mechanisms that orchestrate multiple cell death pathways are unveiled, we propose an updated classification of cell death subroutines focusing on mechanistic and essential (as opposed to correlative and dispensable) aspects of the process. As we provide molecularly oriented definitions of terms including intrinsic apoptosis, extrinsic apoptosis, mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, entotic cell death, NETotic cell death, lysosome-dependent cell death, autophagy-dependent cell death, immunogenic cell death, cellular senescence, and mitotic catastrophe, we discuss the utility of neologisms that refer to highly specialized instances of these processes. The mission of the NCCD is to provide a widely accepted nomenclature on cell death in support of the continued development of the field.

Journal Article, Review
1350-9047
Galluzzi, Lorenzo
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Vitale, Ilio
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Aaronson, Stuart A
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Abrams, John M
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Adam, Dieter
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Agostinis, Patrizia
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Alnemri, Emad S
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Altucci, Lucia
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Amelio, Ivano
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Andrews, David W
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Annicchiarico-Petruzzelli, Margherita
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Antonov, Alexey V
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Arama, Eli
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Baehrecke, Eric H
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Barlev, Nickolai A
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Bazan, Nicolas G
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Bernassola, Francesca
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Bertrand, Mathieu J M
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Bianchi, Katiuscia
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Blagosklonny, Mikhail V
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Blomgren, Klas
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Borner, Christoph
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Boya, Patricia
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Brenner, Catherine
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Campanella, Michelangelo
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Candi, Eleonora
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Carmona-Gutierrez, Didac
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Cecconi, Francesco
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Chan, Francis K-M
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Chandel, Navdeep S
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Cheng, Emily H
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Chipuk, Jerry E
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Cidlowski, John A
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Ciechanover, Aaron
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Cohen, Gerald M
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Conrad, Marcus
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Cubillos-Ruiz, Juan R
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Czabotar, Peter E
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D'Angiolella, Vincenzo
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Dawson, Ted M
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Dawson, Valina L
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De Laurenzi, Vincenzo
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De Maria, Ruggero
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Debatin, Klaus-Michael
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DeBerardinis, Ralph J
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Deshmukh, Mohanish
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Di Daniele, Nicola
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Di Virgilio, Francesco
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Dixit, Vishva M
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Dixon, Scott J
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Duckett, Colin S
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Dynlacht, Brian D
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El-Deiry, Wafik S
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Elrod, John W
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Fimia, Gian Maria
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Fulda, Simone
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García-Sáez, Ana J
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Garg, Abhishek D
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Garrido, Carmen
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Gavathiotis, Evripidis
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Golstein, Pierre
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Gottlieb, Eyal
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Green, Douglas R
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Greene, Lloyd A
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Gronemeyer, Hinrich
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Gross, Atan
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Hajnoczky, Gyorgy
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Hardwick, J Marie
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Harris, Isaac S
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Hengartner, Michael O
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Hetz, Claudio
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Ichijo, Hidenori
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Jäättelä, Marja
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Joseph, Bertrand
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Jost, Philipp J
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Juin, Philippe P
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Kaiser, William J
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Karin, Michael
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Kaufmann, Thomas
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Kepp, Oliver
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Kimchi, Adi
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Kitsis, Richard N
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Klionsky, Daniel J
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Knight, Richard A
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Kumar, Sharad
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Lee, Sam W
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Lemasters, John J
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Levine, Beth
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Linkermann, Andreas
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Lipton, Stuart A
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Lockshin, Richard A
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López-Otín, Carlos
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Lowe, Scott W
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Luedde, Tom
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Lugli, Enrico
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MacFarlane, Marion
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Madeo, Frank
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Malewicz, Michal
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Malorni, Walter
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Manic, Gwenola
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Marine, Jean-Christophe
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Martin, Seamus J
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Martinou, Jean-Claude
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Medema, Jan Paul
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Mehlen, Patrick
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Meier, Pascal
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Melino, Sonia
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Miao, Edward A
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Molkentin, Jeffery D
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Moll, Ute M
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Muñoz-Pinedo, Cristina
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Nagata, Shigekazu
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Nuñez, Gabriel
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Oberst, Andrew
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Oren, Moshe
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Overholtzer, Michael
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Pagano, Michele
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Panaretakis, Theocharis
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Pasparakis, Manolis
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Penninger, Josef M
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Pereira, David M
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Pervaiz, Shazib
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Peter, Marcus E
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Piacentini, Mauro
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Pinton, Paolo
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Prehn, Jochen H M
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Puthalakath, Hamsa
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Rabinovich, Gabriel A
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Rehm, Markus
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Rizzuto, Rosario
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Rodrigues, Cecilia M P
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Rubinsztein, David C
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Rudel, Thomas
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Ryan, Kevin M
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Sayan, Emre
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Scorrano, Luca
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Shao, Feng
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Shi, Yufang
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Silke, John
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Simon, Hans-Uwe
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Sistigu, Antonella
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Stockwell, Brent R
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Strasser, Andreas
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Szabadkai, Gyorgy
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Tait, Stephen W G
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Tang, Daolin
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Tavernarakis, Nektarios
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Thorburn, Andrew
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Tsujimoto, Yoshihide
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Turk, Boris
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Vanden Berghe, Tom
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Vandenabeele, Peter
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Vander Heiden, Matthew G
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Villunger, Andreas
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Virgin, Herbert W
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Vousden, Karen H
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Vucic, Domagoj
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Wagner, Erwin F
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Walczak, Henning
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Wallach, David
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Wang, Ying
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Wells, James A
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Wood, Will
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Yuan, Junying
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Zakeri, Zahra
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Zhivotovsky, Boris
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Zitvogel, Laurence
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Melino, Gerry
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Kroemer, Guido
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Galluzzi, Lorenzo
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Vitale, Ilio
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Aaronson, Stuart A
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Abrams, John M
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Adam, Dieter
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Agostinis, Patrizia
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Alnemri, Emad S
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Altucci, Lucia
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Amelio, Ivano
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Andrews, David W
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Annicchiarico-Petruzzelli, Margherita
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Antonov, Alexey V
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Arama, Eli
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Baehrecke, Eric H
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Barlev, Nickolai A
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Bazan, Nicolas G
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Bernassola, Francesca
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Bertrand, Mathieu J M
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Bianchi, Katiuscia
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Blagosklonny, Mikhail V
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Blomgren, Klas
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Borner, Christoph
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Boya, Patricia
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Brenner, Catherine
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Campanella, Michelangelo
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Candi, Eleonora
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Carmona-Gutierrez, Didac
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Cecconi, Francesco
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Chan, Francis K-M
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Chandel, Navdeep S
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Cheng, Emily H
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Chipuk, Jerry E
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Cidlowski, John A
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Ciechanover, Aaron
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Cohen, Gerald M
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Conrad, Marcus
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Cubillos-Ruiz, Juan R
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Czabotar, Peter E
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D'Angiolella, Vincenzo
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Dawson, Ted M
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Dawson, Valina L
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De Laurenzi, Vincenzo
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De Maria, Ruggero
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Debatin, Klaus-Michael
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DeBerardinis, Ralph J
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Deshmukh, Mohanish
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Di Daniele, Nicola
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Di Virgilio, Francesco
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Dixit, Vishva M
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Dixon, Scott J
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Duckett, Colin S
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Dynlacht, Brian D
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El-Deiry, Wafik S
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Elrod, John W
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Fimia, Gian Maria
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Fulda, Simone
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García-Sáez, Ana J
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Garg, Abhishek D
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Garrido, Carmen
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Gavathiotis, Evripidis
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Overholtzer, Michael
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Pagano, Michele
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Panaretakis, Theocharis
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Pasparakis, Manolis
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Penninger, Josef M
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Pereira, David M
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Pervaiz, Shazib
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Piacentini, Mauro
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Galluzzi, Lorenzo, Vitale, Ilio, Aaronson, Stuart A, Abrams, John M, Adam, Dieter, Agostinis, Patrizia, Alnemri, Emad S, Altucci, Lucia, Amelio, Ivano, Andrews, David W, Annicchiarico-Petruzzelli, Margherita, Antonov, Alexey V, Arama, Eli, Baehrecke, Eric H, Barlev, Nickolai A, Bazan, Nicolas G, Bernassola, Francesca, Bertrand, Mathieu J M, Bianchi, Katiuscia, Blagosklonny, Mikhail V, Blomgren, Klas, Borner, Christoph, Boya, Patricia, Brenner, Catherine, Campanella, Michelangelo, Candi, Eleonora, Carmona-Gutierrez, Didac, Cecconi, Francesco, Chan, Francis K-M, Chandel, Navdeep S, Cheng, Emily H, Chipuk, Jerry E, Cidlowski, John A, Ciechanover, Aaron, Cohen, Gerald M, Conrad, Marcus, Cubillos-Ruiz, Juan R, Czabotar, Peter E, D'Angiolella, Vincenzo, Dawson, Ted M, Dawson, Valina L, De Laurenzi, Vincenzo, De Maria, Ruggero, Debatin, Klaus-Michael, DeBerardinis, Ralph J, Deshmukh, Mohanish, Di Daniele, Nicola, Di Virgilio, Francesco, Dixit, Vishva M, Dixon, Scott J, Duckett, Colin S, Dynlacht, Brian D, El-Deiry, Wafik S, Elrod, John W, Fimia, Gian Maria, Fulda, Simone, García-Sáez, Ana J, Garg, Abhishek D, Garrido, Carmen, Gavathiotis, Evripidis, Golstein, Pierre, Gottlieb, Eyal, Green, Douglas R, Greene, Lloyd A, Gronemeyer, Hinrich, Gross, Atan, Hajnoczky, Gyorgy, Hardwick, J Marie, Harris, Isaac S, Hengartner, Michael O, Hetz, Claudio, Ichijo, Hidenori, Jäättelä, Marja, Joseph, Bertrand, Jost, Philipp J, Juin, Philippe P, Kaiser, William J, Karin, Michael, Kaufmann, Thomas, Kepp, Oliver, Kimchi, Adi, Kitsis, Richard N, Klionsky, Daniel J, Knight, Richard A, Kumar, Sharad, Lee, Sam W, Lemasters, John J, Levine, Beth, Linkermann, Andreas, Lipton, Stuart A, Lockshin, Richard A, López-Otín, Carlos, Lowe, Scott W, Luedde, Tom, Lugli, Enrico, MacFarlane, Marion, Madeo, Frank, Malewicz, Michal, Malorni, Walter, Manic, Gwenola, Marine, Jean-Christophe, Martin, Seamus J, Martinou, Jean-Claude, Medema, Jan Paul, Mehlen, Patrick, Meier, Pascal, Melino, Sonia, Miao, Edward A, Molkentin, Jeffery D, Moll, Ute M, Muñoz-Pinedo, Cristina, Nagata, Shigekazu, Nuñez, Gabriel, Oberst, Andrew, Oren, Moshe, Overholtzer, Michael, Pagano, Michele, Panaretakis, Theocharis, Pasparakis, Manolis, Penninger, Josef M, Pereira, David M, Pervaiz, Shazib, Peter, Marcus E, Piacentini, Mauro, Pinton, Paolo, Prehn, Jochen H M, Puthalakath, Hamsa, Rabinovich, Gabriel A, Rehm, Markus, Rizzuto, Rosario, Rodrigues, Cecilia M P, Rubinsztein, David C, Rudel, Thomas, Ryan, Kevin M, Sayan, Emre, Scorrano, Luca, Shao, Feng, Shi, Yufang, Silke, John, Simon, Hans-Uwe, Sistigu, Antonella, Stockwell, Brent R, Strasser, Andreas, Szabadkai, Gyorgy, Tait, Stephen W G, Tang, Daolin, Tavernarakis, Nektarios, Thorburn, Andrew, Tsujimoto, Yoshihide, Turk, Boris, Vanden Berghe, Tom, Vandenabeele, Peter, Vander Heiden, Matthew G, Villunger, Andreas, Virgin, Herbert W, Vousden, Karen H, Vucic, Domagoj, Wagner, Erwin F, Walczak, Henning, Wallach, David, Wang, Ying, Wells, James A, Wood, Will, Yuan, Junying, Zakeri, Zahra, Zhivotovsky, Boris, Zitvogel, Laurence, Melino, Gerry and Kroemer, Guido (2018) Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death and Differentiation. (doi:10.1038/s41418-017-0012-4).

Record type: Review

Abstract

Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives. Since the field continues to expand and novel mechanisms that orchestrate multiple cell death pathways are unveiled, we propose an updated classification of cell death subroutines focusing on mechanistic and essential (as opposed to correlative and dispensable) aspects of the process. As we provide molecularly oriented definitions of terms including intrinsic apoptosis, extrinsic apoptosis, mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, entotic cell death, NETotic cell death, lysosome-dependent cell death, autophagy-dependent cell death, immunogenic cell death, cellular senescence, and mitotic catastrophe, we discuss the utility of neologisms that refer to highly specialized instances of these processes. The mission of the NCCD is to provide a widely accepted nomenclature on cell death in support of the continued development of the field.

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Accepted/In Press date: 13 October 2017
e-pub ahead of print date: 23 January 2018
Keywords: Journal Article, Review

Identifiers

Local EPrints ID: 417640
URI: https://eprints.soton.ac.uk/id/eprint/417640
ISSN: 1350-9047
PURE UUID: 02e0e0e8-a7b8-4286-87e0-bddde0054b8e

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Date deposited: 08 Feb 2018 17:30
Last modified: 28 Apr 2018 16:30

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Contributors

Author: Lorenzo Galluzzi
Author: Ilio Vitale
Author: Stuart A Aaronson
Author: John M Abrams
Author: Dieter Adam
Author: Patrizia Agostinis
Author: Emad S Alnemri
Author: Lucia Altucci
Author: Ivano Amelio
Author: David W Andrews
Author: Margherita Annicchiarico-Petruzzelli
Author: Alexey V Antonov
Author: Eli Arama
Author: Eric H Baehrecke
Author: Nickolai A Barlev
Author: Nicolas G Bazan
Author: Francesca Bernassola
Author: Mathieu J M Bertrand
Author: Katiuscia Bianchi
Author: Mikhail V Blagosklonny
Author: Klas Blomgren
Author: Christoph Borner
Author: Patricia Boya
Author: Catherine Brenner
Author: Michelangelo Campanella
Author: Eleonora Candi
Author: Didac Carmona-Gutierrez
Author: Francesco Cecconi
Author: Francis K-M Chan
Author: Navdeep S Chandel
Author: Emily H Cheng
Author: Jerry E Chipuk
Author: John A Cidlowski
Author: Aaron Ciechanover
Author: Gerald M Cohen
Author: Marcus Conrad
Author: Juan R Cubillos-Ruiz
Author: Peter E Czabotar
Author: Vincenzo D'Angiolella
Author: Ted M Dawson
Author: Valina L Dawson
Author: Vincenzo De Laurenzi
Author: Ruggero De Maria
Author: Klaus-Michael Debatin
Author: Ralph J DeBerardinis
Author: Mohanish Deshmukh
Author: Nicola Di Daniele
Author: Francesco Di Virgilio
Author: Vishva M Dixit
Author: Scott J Dixon
Author: Colin S Duckett
Author: Brian D Dynlacht
Author: Wafik S El-Deiry
Author: John W Elrod
Author: Gian Maria Fimia
Author: Simone Fulda
Author: Ana J García-Sáez
Author: Abhishek D Garg
Author: Carmen Garrido
Author: Evripidis Gavathiotis
Author: Pierre Golstein
Author: Eyal Gottlieb
Author: Douglas R Green
Author: Lloyd A Greene
Author: Hinrich Gronemeyer
Author: Atan Gross
Author: Gyorgy Hajnoczky
Author: J Marie Hardwick
Author: Isaac S Harris
Author: Michael O Hengartner
Author: Claudio Hetz
Author: Hidenori Ichijo
Author: Marja Jäättelä
Author: Bertrand Joseph
Author: Philipp J Jost
Author: Philippe P Juin
Author: William J Kaiser
Author: Michael Karin
Author: Thomas Kaufmann
Author: Oliver Kepp
Author: Adi Kimchi
Author: Richard N Kitsis
Author: Daniel J Klionsky
Author: Richard A Knight
Author: Sharad Kumar
Author: Sam W Lee
Author: John J Lemasters
Author: Beth Levine
Author: Andreas Linkermann
Author: Stuart A Lipton
Author: Richard A Lockshin
Author: Carlos López-Otín
Author: Scott W Lowe
Author: Tom Luedde
Author: Enrico Lugli
Author: Marion MacFarlane
Author: Frank Madeo
Author: Michal Malewicz
Author: Walter Malorni
Author: Gwenola Manic
Author: Jean-Christophe Marine
Author: Seamus J Martin
Author: Jean-Claude Martinou
Author: Jan Paul Medema
Author: Patrick Mehlen
Author: Pascal Meier
Author: Sonia Melino
Author: Edward A Miao
Author: Jeffery D Molkentin
Author: Ute M Moll
Author: Cristina Muñoz-Pinedo
Author: Shigekazu Nagata
Author: Gabriel Nuñez
Author: Andrew Oberst
Author: Moshe Oren
Author: Michael Overholtzer
Author: Michele Pagano
Author: Theocharis Panaretakis
Author: Manolis Pasparakis
Author: Josef M Penninger
Author: David M Pereira
Author: Shazib Pervaiz
Author: Marcus E Peter
Author: Mauro Piacentini
Author: Paolo Pinton
Author: Jochen H M Prehn
Author: Hamsa Puthalakath
Author: Gabriel A Rabinovich
Author: Markus Rehm
Author: Rosario Rizzuto
Author: Cecilia M P Rodrigues
Author: David C Rubinsztein
Author: Thomas Rudel
Author: Kevin M Ryan
Author: Emre Sayan
Author: Luca Scorrano
Author: Feng Shao
Author: Yufang Shi
Author: John Silke
Author: Hans-Uwe Simon
Author: Antonella Sistigu
Author: Brent R Stockwell
Author: Andreas Strasser
Author: Gyorgy Szabadkai
Author: Stephen W G Tait
Author: Daolin Tang
Author: Nektarios Tavernarakis
Author: Andrew Thorburn
Author: Yoshihide Tsujimoto
Author: Boris Turk
Author: Tom Vanden Berghe
Author: Peter Vandenabeele
Author: Matthew G Vander Heiden
Author: Andreas Villunger
Author: Herbert W Virgin
Author: Karen H Vousden
Author: Domagoj Vucic
Author: Erwin F Wagner
Author: Henning Walczak
Author: David Wallach
Author: Ying Wang
Author: James A Wells
Author: Will Wood
Author: Junying Yuan
Author: Zahra Zakeri
Author: Boris Zhivotovsky
Author: Laurence Zitvogel
Author: Gerry Melino
Author: Guido Kroemer

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