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Origins of lifetime health around the time of conception: causes and consequences

Origins of lifetime health around the time of conception: causes and consequences
Origins of lifetime health around the time of conception: causes and consequences
Parental environmental factors including diet, body composition, metabolism and stress affect the health and chronic disease risk of people throughout their lives, as captured in the ‘Developmental Origins of Health and Disease’ (DOHaD) concept. Research across epidemiological, clinical and basic science fields has identified the period around conception as being critical in the processes mediating parental influences on the next generation’s health. During this time, from the maturation of gametes through to early embryonic development, parental lifestyle can adversely influence long-term risks of offspring cardiovascular, metabolic, immune and neurological morbidities, often termed ‘developmental programming’. We review ‘periconceptional’ induction of disease risk from four broad exposures: maternal overnutrition and obesity; maternal undernutrition; related paternal factors; and from the use of assisted reproductive treatment. Human studies and animal models demonstrate the underlying biological mechanisms, including epigenetic, cellular, physiological and metabolic processes. A novel meta-analysis of mouse paternal and maternal protein undernutrition indicate distinct parental periconceptional contributions to postnatal outcomes. We propose that the evidence for periconceptional effects on lifetime health is now so compelling that it calls for new guidance on parental preparation for pregnancy, beginning before conception, to protect the health of offspring.
0140-6736
1842–1852
Fleming, T.P.
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Watkins, A.
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Velazquez, M.A.
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Mathers, J. C.
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Prentice, A.M.
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Stephenson, J.
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Barker, Mary
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Saffery, R.
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Yajnik, Chittaranjan S.
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Eckert, Judith
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Hanson, Mark
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Forrester, T.
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Gluckman, Peter D.
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Godfrey, Keith
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Fleming, T.P.
1431b2dc-b145-4bc2-aea4-bc360fc370e9
Watkins, A.
122e9b72-0622-41bd-b98b-e2c9ae8afe11
Velazquez, M.A.
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Mathers, J. C.
4c3a2689-21c5-4449-83fa-636a20dce0b3
Prentice, A.M.
79bebd56-9f48-4687-9fbc-708b6a418f37
Stephenson, J.
b85633be-3938-4dcc-8907-82bc93a34d1f
Barker, Mary
374310ad-d308-44af-b6da-515bf5d2d6d2
Saffery, R.
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Yajnik, Chittaranjan S.
f5777038-bba7-49bd-80b9-be4e586eecf4
Eckert, Judith
729bfa49-7053-458d-8e84-3e70e4d98e57
Hanson, Mark
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Forrester, T.
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Gluckman, Peter D.
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Godfrey, Keith
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd

Fleming, T.P., Watkins, A., Velazquez, M.A., Mathers, J. C., Prentice, A.M., Stephenson, J., Barker, Mary, Saffery, R., Yajnik, Chittaranjan S., Eckert, Judith, Hanson, Mark, Forrester, T., Gluckman, Peter D. and Godfrey, Keith (2018) Origins of lifetime health around the time of conception: causes and consequences. The Lancet, 391 (10132), 1842–1852. (doi:10.1016/S0140-6736(18)30312-X).

Record type: Article

Abstract

Parental environmental factors including diet, body composition, metabolism and stress affect the health and chronic disease risk of people throughout their lives, as captured in the ‘Developmental Origins of Health and Disease’ (DOHaD) concept. Research across epidemiological, clinical and basic science fields has identified the period around conception as being critical in the processes mediating parental influences on the next generation’s health. During this time, from the maturation of gametes through to early embryonic development, parental lifestyle can adversely influence long-term risks of offspring cardiovascular, metabolic, immune and neurological morbidities, often termed ‘developmental programming’. We review ‘periconceptional’ induction of disease risk from four broad exposures: maternal overnutrition and obesity; maternal undernutrition; related paternal factors; and from the use of assisted reproductive treatment. Human studies and animal models demonstrate the underlying biological mechanisms, including epigenetic, cellular, physiological and metabolic processes. A novel meta-analysis of mouse paternal and maternal protein undernutrition indicate distinct parental periconceptional contributions to postnatal outcomes. We propose that the evidence for periconceptional effects on lifetime health is now so compelling that it calls for new guidance on parental preparation for pregnancy, beginning before conception, to protect the health of offspring.

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More information

Accepted/In Press date: 31 January 2018
e-pub ahead of print date: 16 April 2018
Published date: 5 May 2018

Identifiers

Local EPrints ID: 417666
URI: https://eprints.soton.ac.uk/id/eprint/417666
ISSN: 0140-6736
PURE UUID: fb85adf1-fb65-4fdb-a5db-96d9ef078e2f
ORCID for Mary Barker: ORCID iD orcid.org/0000-0003-2976-0217
ORCID for Mark Hanson: ORCID iD orcid.org/0000-0002-6907-613X
ORCID for Keith Godfrey: ORCID iD orcid.org/0000-0002-4643-0618

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Date deposited: 09 Feb 2018 17:30
Last modified: 03 Dec 2019 05:36

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Contributors

Author: T.P. Fleming
Author: A. Watkins
Author: M.A. Velazquez
Author: J. C. Mathers
Author: A.M. Prentice
Author: J. Stephenson
Author: Mary Barker ORCID iD
Author: R. Saffery
Author: Chittaranjan S. Yajnik
Author: Judith Eckert
Author: Mark Hanson ORCID iD
Author: T. Forrester
Author: Peter D. Gluckman
Author: Keith Godfrey ORCID iD

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