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Associations of childhood and adulthood cognition with bone mineral density in later adulthood: a population-based longitudinal study

Associations of childhood and adulthood cognition with bone mineral density in later adulthood: a population-based longitudinal study
Associations of childhood and adulthood cognition with bone mineral density in later adulthood: a population-based longitudinal study
This study explores the association between cognitive ability in childhood and midlife and bone health outcomes in early old age; and the relationships of these bone measures with contemporaneous and subsequent cognitive ability in the MRC National Survey of Health and Development (NSHD). This British birth cohort assessed areal and volumetric bone mineral density (aBMD and vBMD) at age 60–64, derived from peripheral quantitative computed tomography and dual-energy X-ray absorptiometry, and cognitive performance from childhood to age 69, among 866 women and 792 men. Cognitive performance at age 15 was assessed using tests of verbal and non-verbal ability, and mathematics; and memory and search speed tasks were administered at ages 53, 60–64, and 69. Covariates included body size, pubertal timing, smoking, leisure time physical activity, socioeconomic circumstances and menopause timing. Multiple linear regression analyses showed that higher childhood cognitive ability was associated with higher hip aBMD, in women, and greater cortical and trabecular vBMD, in men. For women, there were positive associations between hip aBMD and total vBMD, and contemporaneous cognitive ability with associations also extending to subsequent cognitive ability for total vBMD. For men, some associations with trabecular and total vBMD emerged at ages 60–64 and 69 but only after adjusting for education, occupational class and health behaviors. Our findings highlight that higher cognitive ability in childhood is associated with BMD in early old age and these associations might be explained by social and behavioral pathways. The results suggest that individuals with greater cognitive ability in early life are more likely to engage in healthy behaviors (e.g., leisure time physical activity) in adulthood, which in turn are associated with greater BMD later in life. Associations between bone health and cognitive performance should be considered within a life course framework; and the potential role of smoking and physical activity should be addressed when advising adults at high future risk of osteoporosis and fracture.
1663-4365
Bendayan, R.
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Kuh, D.
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Cooper, R.
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Murthuri, S.
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Muniz-Terrera, G.
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Adams, J
fbe5d085-ac98-4962-8f13-b96029380352
Ward, Kathryn
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Richards, M
fb2a2c42-9deb-4a40-b594-a1a63073a3a3
Bendayan, R.
b33c7de3-878a-46bd-a40a-74a64925ed56
Kuh, D.
6c5d95a4-433d-4895-bd95-86a7d5fe76a5
Cooper, R.
6cd7b578-a1fa-4511-bc7d-9addc4baf372
Murthuri, S.
9e2d94d5-6b61-4261-a76b-5bb920260d5f
Muniz-Terrera, G.
b1dd9234-1c31-4991-ad7a-94dbb67437af
Adams, J
fbe5d085-ac98-4962-8f13-b96029380352
Ward, Kathryn
39bd4db1-c948-4e32-930e-7bec8deb54c7
Richards, M
fb2a2c42-9deb-4a40-b594-a1a63073a3a3

Bendayan, R., Kuh, D., Cooper, R., Murthuri, S., Muniz-Terrera, G., Adams, J, Ward, Kathryn and Richards, M (2017) Associations of childhood and adulthood cognition with bone mineral density in later adulthood: a population-based longitudinal study. Frontiers in Aging Neuroscience, 9. (doi:10.3389/fnagi.2017.00241).

Record type: Article

Abstract

This study explores the association between cognitive ability in childhood and midlife and bone health outcomes in early old age; and the relationships of these bone measures with contemporaneous and subsequent cognitive ability in the MRC National Survey of Health and Development (NSHD). This British birth cohort assessed areal and volumetric bone mineral density (aBMD and vBMD) at age 60–64, derived from peripheral quantitative computed tomography and dual-energy X-ray absorptiometry, and cognitive performance from childhood to age 69, among 866 women and 792 men. Cognitive performance at age 15 was assessed using tests of verbal and non-verbal ability, and mathematics; and memory and search speed tasks were administered at ages 53, 60–64, and 69. Covariates included body size, pubertal timing, smoking, leisure time physical activity, socioeconomic circumstances and menopause timing. Multiple linear regression analyses showed that higher childhood cognitive ability was associated with higher hip aBMD, in women, and greater cortical and trabecular vBMD, in men. For women, there were positive associations between hip aBMD and total vBMD, and contemporaneous cognitive ability with associations also extending to subsequent cognitive ability for total vBMD. For men, some associations with trabecular and total vBMD emerged at ages 60–64 and 69 but only after adjusting for education, occupational class and health behaviors. Our findings highlight that higher cognitive ability in childhood is associated with BMD in early old age and these associations might be explained by social and behavioral pathways. The results suggest that individuals with greater cognitive ability in early life are more likely to engage in healthy behaviors (e.g., leisure time physical activity) in adulthood, which in turn are associated with greater BMD later in life. Associations between bone health and cognitive performance should be considered within a life course framework; and the potential role of smoking and physical activity should be addressed when advising adults at high future risk of osteoporosis and fracture.

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Accepted/In Press date: 10 July 2017
e-pub ahead of print date: 25 July 2017

Identifiers

Local EPrints ID: 417731
URI: https://eprints.soton.ac.uk/id/eprint/417731
ISSN: 1663-4365
PURE UUID: 15fc8439-97db-4e6e-b1d8-98a3ccf9d913
ORCID for Kathryn Ward: ORCID iD orcid.org/0000-0001-7034-6750

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Date deposited: 12 Feb 2018 17:30
Last modified: 11 Apr 2019 00:29

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Contributors

Author: R. Bendayan
Author: D. Kuh
Author: R. Cooper
Author: S. Murthuri
Author: G. Muniz-Terrera
Author: J Adams
Author: Kathryn Ward ORCID iD
Author: M Richards

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