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Communication between the leaflets of asymmetric membranes revealed from coarse-grain molecular dynamics simulations

Communication between the leaflets of asymmetric membranes revealed from coarse-grain molecular dynamics simulations
Communication between the leaflets of asymmetric membranes revealed from coarse-grain molecular dynamics simulations

We use coarse-grain molecular simulations to investigate the structural and dynamics differences between an asymmetric and a symmetrical membrane, both containing beta barrel transmembrane proteins. We find in where the dynamics of the two leaflets differ greatly, the slowest leaflet dominates the structural effects and importance of protein-lipid interactions.

2045-2322
1-6
Shearer, Jonathan, Roy William
44810f0c-f875-465e-be3b-810155814bc5
Khalid, Syma
90fbd954-7248-4f47-9525-4d6af9636394
Shearer, Jonathan, Roy William
44810f0c-f875-465e-be3b-810155814bc5
Khalid, Syma
90fbd954-7248-4f47-9525-4d6af9636394

Shearer, Jonathan, Roy William and Khalid, Syma (2018) Communication between the leaflets of asymmetric membranes revealed from coarse-grain molecular dynamics simulations. Scientific Reports, 8 (1), 1-6, [1805]. (doi:10.1038/s41598-018-20227-1).

Record type: Article

Abstract

We use coarse-grain molecular simulations to investigate the structural and dynamics differences between an asymmetric and a symmetrical membrane, both containing beta barrel transmembrane proteins. We find in where the dynamics of the two leaflets differ greatly, the slowest leaflet dominates the structural effects and importance of protein-lipid interactions.

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41598-018-20227-1 - Version of Record
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Accepted/In Press date: 4 January 2018
e-pub ahead of print date: 29 January 2018
Published date: 1 December 2018
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Identifiers

Local EPrints ID: 417777
URI: http://eprints.soton.ac.uk/id/eprint/417777
DOI: doi:10.1038/s41598-018-20227-1
ISSN: 2045-2322
PURE UUID: 4c20275e-30e5-4d30-b5b7-cf402ca19715
ORCID for Syma Khalid: ORCID iD orcid.org/0000-0002-3694-5044

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Date deposited: 14 Feb 2018 17:30
Last modified: 16 Mar 2024 03:56

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Contributors

Author: Jonathan, Roy William Shearer
Author: Syma Khalid ORCID iD

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