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Molecular dynamic studies of the antimicrobial peptide Dermaseptin B2 and its derivative Dermaseptin DS01

Molecular dynamic studies of the antimicrobial peptide Dermaseptin B2 and its derivative Dermaseptin DS01
Molecular dynamic studies of the antimicrobial peptide Dermaseptin B2 and its derivative Dermaseptin DS01
Rapid development of resistance to antimicrobials and the lack of new therapy development are critical issues facing infectious disease treatment globally. Over the past two decades, antimicrobial peptides (AMPs) have been extensively researched and shown to exhibit broad-spectrum activity against various microbes, viruses, fungi and even cancerous cells, thus they are thought to have the solution to the increasing resistance problem. Understanding the role that antimicrobial peptides play in preventing infections is essential if these peptides are to form a new class of clinically effective antimicrobial agents and for them to be used therapeutically in humans. This research will look at a family of antimicrobial peptides known as Dermaseptin that are secreted by an Amazonian frog species. These peptides have shown potent activity against Gram-negative and positive bacteria, viruses, fungi and cancer cells. They exhibit bacterial colony inhibition effect at the micromolar concentration level with minimal effect on host cells. For its high potency and lack of toxicity to host cell, the Dermaseptin family appears to have therapeutic potential and this thesis will attempt to understand how they interact with membranes at the molecular level using coarse-grained computational models and simulations.
University of Southampton
Elhussein, Malaz
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Elhussein, Malaz
70264e9a-dbc9-40d1-8abd-64a3594d2815
Khalid, Syma
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Elhussein, Malaz (2015) Molecular dynamic studies of the antimicrobial peptide Dermaseptin B2 and its derivative Dermaseptin DS01. University of Southampton, Doctoral Thesis, 183pp.

Record type: Thesis (Doctoral)

Abstract

Rapid development of resistance to antimicrobials and the lack of new therapy development are critical issues facing infectious disease treatment globally. Over the past two decades, antimicrobial peptides (AMPs) have been extensively researched and shown to exhibit broad-spectrum activity against various microbes, viruses, fungi and even cancerous cells, thus they are thought to have the solution to the increasing resistance problem. Understanding the role that antimicrobial peptides play in preventing infections is essential if these peptides are to form a new class of clinically effective antimicrobial agents and for them to be used therapeutically in humans. This research will look at a family of antimicrobial peptides known as Dermaseptin that are secreted by an Amazonian frog species. These peptides have shown potent activity against Gram-negative and positive bacteria, viruses, fungi and cancer cells. They exhibit bacterial colony inhibition effect at the micromolar concentration level with minimal effect on host cells. For its high potency and lack of toxicity to host cell, the Dermaseptin family appears to have therapeutic potential and this thesis will attempt to understand how they interact with membranes at the molecular level using coarse-grained computational models and simulations.

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Published date: September 2015

Identifiers

Local EPrints ID: 417808
URI: http://eprints.soton.ac.uk/id/eprint/417808
PURE UUID: e20304e3-3942-4ea5-aedc-ca1c55e93ef0
ORCID for Syma Khalid: ORCID iD orcid.org/0000-0002-3694-5044

Catalogue record

Date deposited: 14 Feb 2018 17:30
Last modified: 20 Nov 2020 05:01

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Contributors

Author: Malaz Elhussein
Thesis advisor: Syma Khalid ORCID iD

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