The evolving dialogue of microglia and neurons in Alzheimer's disease: microglia as necessary transducers of pathology
The evolving dialogue of microglia and neurons in Alzheimer's disease: microglia as necessary transducers of pathology
The understanding of the contribution of microglial cells to the onset and/or progression chronic neurodegenerative diseases is key to identify disease-modifying therapies, given the strong neuroimmune component of these disorders. In this review, we dissect the different pathways by which microglia can affect, directly or indirectly, neuronal function and dysfunction associated with diseases like Alzheimer’s. We here present the rationale for proposing a model to explain the contribution of microglia to the pathophysiology of Alzheimer’s disease, defining microglial cells as necessary transducers of pathology and ideal targets for intervention.
Simon, Emilie
22a3ee84-1834-4038-91cb-15d6163b1c56
Obst, Juliane
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Gomez-Nicola, Diego
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Simon, Emilie
22a3ee84-1834-4038-91cb-15d6163b1c56
Obst, Juliane
0c499ee6-0290-4792-8c99-049e05332227
Gomez-Nicola, Diego
0680aa66-9dee-47cf-a8d3-e39c988f85b5
Simon, Emilie, Obst, Juliane and Gomez-Nicola, Diego
(2018)
The evolving dialogue of microglia and neurons in Alzheimer's disease: microglia as necessary transducers of pathology.
Neuroscience.
(doi:10.1016/j.neuroscience.2018.01.059).
Abstract
The understanding of the contribution of microglial cells to the onset and/or progression chronic neurodegenerative diseases is key to identify disease-modifying therapies, given the strong neuroimmune component of these disorders. In this review, we dissect the different pathways by which microglia can affect, directly or indirectly, neuronal function and dysfunction associated with diseases like Alzheimer’s. We here present the rationale for proposing a model to explain the contribution of microglia to the pathophysiology of Alzheimer’s disease, defining microglial cells as necessary transducers of pathology and ideal targets for intervention.
Text
1-s2.0-S0306452218300897-main
- Accepted Manuscript
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Accepted/In Press date: 29 January 2018
e-pub ahead of print date: 7 February 2018
Identifiers
Local EPrints ID: 417891
URI: http://eprints.soton.ac.uk/id/eprint/417891
ISSN: 0306-4522
PURE UUID: c545552c-88c2-470f-ab7f-eb57ff418829
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Date deposited: 16 Feb 2018 17:30
Last modified: 16 Mar 2024 06:12
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Author:
Emilie Simon
Author:
Juliane Obst
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