Major histocompatibility complex class I antigen presentation

Van Hateren, Andrew (2016) Major histocompatibility complex class I antigen presentation. In, Ratcliffe, Michael (ed.) Encyclopedia of Immunobiology. 1 ed. Academic Press.

Record type: Book Section

Abstract

At the cell surface the function of Major Histocompatibility Complex class I proteins (MHC I) is to present peptide to T cell receptors (TcR) and recruit cofactor CD8. Inside the cell the function of MHC I is to select peptides for presentation (collectively forming the immunome) from a pool (collectively called the peptidome) derived mainly in the cytoplasm and delivered to the endoplasmic reticulum by TAP, the transporter associated with antigen presentation. MHC I peptide selection is assisted by cofactors in the early secretory pathway including the peptide-loading complex (PLC) in the ER which comprises newly assembled MHCI:beta2-microglobulin (b2m), tapasin, ERp57, calreticulin and TAP; and UDP-glucose:glycoprotein glucosyltransferase (UGGT), the tapasin-related protein TAPBPR and calreticulin in the Cis-Golgi. Initial binding of peptides to MHC is not thought to be very selective: selection is achieved by subsequent “filtration” or “refinement” steps. The first occurs in the PLC and is assisted primarily by tapasin; the second occurs in the cis Golgi network and is assisted primarily by TAPBPR, UGGT and calreticulin, and the third occurs at the cell surface.

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