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The effect of vitamin A supplementation on serum retinol and retinol binding protein levels

The effect of vitamin A supplementation on serum retinol and retinol binding protein levels
The effect of vitamin A supplementation on serum retinol and retinol binding protein levels
A randomised double blind controlled trial was conduced to see whether vitamin A supplementation in the form of retinyl palmitate would increase the concentrations of serum retinol and retinol binding protein. A total of 376 people were studied and were allocated to one of 7 regimens covering doses of vitamin A from 0 (placebo) to 36,000 IU daily. Supplementation continued for 6 months and blood samples were collected immediately before the start of supplementation, after 3 months and after 6 months. There was a small but statistically significant increase in serum retinol levels associated with supplementation, but no significant increase in serum retinol binding protein. The extent of the increase in serum retinol was related to the extent of the supplementation. On average, for every 10,000 IU of retinyl palmitate per day, the serum retinol concentration increased by 13 μg/l after 3 months (an increase of 2%) and 12 μg/l after 6 months of supplementation (2% increase). All the regimens used showed no evidence of toxicity other than minor symptomatic and physical changes affecting the skin and mucous membranes.
0304-3835
203-213
Wald, N.J.
ab02141b-306d-4d4f-8986-59274565dafb
Cuckle, H.S.
565bc95d-fa21-42fc-9ab3-3346dbec2d5b
Barlow, R.D.
8864bd3c-0c94-4b17-98e5-7348983743c6
Thompson, P.
0a0015a4-61ee-473c-9e4b-8afca6adff45
Nanchahal, K.
221d187e-c494-4846-bb6c-aae1619d8ee9
Blow, R.J.
911643f3-8600-4525-9f47-6d394a5dd2d4
Brown, I.
13b13988-789f-40e2-a2d8-8f326f68eedd
Harling, C.C.
5aa04b75-8f5d-4754-a999-e11c84831f64
McCulloch, W.J.
9978273f-dda3-478c-8179-7bf3e065d7d1
Morgan, J.
7891d404-a419-4f8e-94db-09d7925209e5
Reid, A.R.
61b9df80-e4a5-4a47-8bad-3b0901cc061f
Wald, N.J.
ab02141b-306d-4d4f-8986-59274565dafb
Cuckle, H.S.
565bc95d-fa21-42fc-9ab3-3346dbec2d5b
Barlow, R.D.
8864bd3c-0c94-4b17-98e5-7348983743c6
Thompson, P.
0a0015a4-61ee-473c-9e4b-8afca6adff45
Nanchahal, K.
221d187e-c494-4846-bb6c-aae1619d8ee9
Blow, R.J.
911643f3-8600-4525-9f47-6d394a5dd2d4
Brown, I.
13b13988-789f-40e2-a2d8-8f326f68eedd
Harling, C.C.
5aa04b75-8f5d-4754-a999-e11c84831f64
McCulloch, W.J.
9978273f-dda3-478c-8179-7bf3e065d7d1
Morgan, J.
7891d404-a419-4f8e-94db-09d7925209e5
Reid, A.R.
61b9df80-e4a5-4a47-8bad-3b0901cc061f

Wald, N.J., Cuckle, H.S., Barlow, R.D., Thompson, P., Nanchahal, K., Blow, R.J., Brown, I., Harling, C.C., McCulloch, W.J., Morgan, J. and Reid, A.R. (1985) The effect of vitamin A supplementation on serum retinol and retinol binding protein levels. Cancer Letters, 29 (2), 203-213. (doi:10.1016/0304-3835(85)90160-0).

Record type: Article

Abstract

A randomised double blind controlled trial was conduced to see whether vitamin A supplementation in the form of retinyl palmitate would increase the concentrations of serum retinol and retinol binding protein. A total of 376 people were studied and were allocated to one of 7 regimens covering doses of vitamin A from 0 (placebo) to 36,000 IU daily. Supplementation continued for 6 months and blood samples were collected immediately before the start of supplementation, after 3 months and after 6 months. There was a small but statistically significant increase in serum retinol levels associated with supplementation, but no significant increase in serum retinol binding protein. The extent of the increase in serum retinol was related to the extent of the supplementation. On average, for every 10,000 IU of retinyl palmitate per day, the serum retinol concentration increased by 13 μg/l after 3 months (an increase of 2%) and 12 μg/l after 6 months of supplementation (2% increase). All the regimens used showed no evidence of toxicity other than minor symptomatic and physical changes affecting the skin and mucous membranes.

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Accepted/In Press date: 12 September 1985
Published date: November 1985

Identifiers

Local EPrints ID: 417918
URI: https://eprints.soton.ac.uk/id/eprint/417918
ISSN: 0304-3835
PURE UUID: dfa2de54-8745-40e1-9a5a-5d70a598a256
ORCID for C.C. Harling: ORCID iD orcid.org/0000-0001-5122-2568

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Date deposited: 16 Feb 2018 17:30
Last modified: 14 Mar 2019 01:26

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Contributors

Author: N.J. Wald
Author: H.S. Cuckle
Author: R.D. Barlow
Author: P. Thompson
Author: K. Nanchahal
Author: R.J. Blow
Author: I. Brown
Author: C.C. Harling ORCID iD
Author: W.J. McCulloch
Author: J. Morgan
Author: A.R. Reid

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