Contact dependent suppression of CD4 T cell activation and proliferation by B cells activated through IgD cross-linking

Preciado-Llanes, Lorena, Wing, James B., Foster, Rachel A., Carlring, Jennifer, Lees, Andrew, Read, Robert C. and Heath, Andrew W. (2015) Contact dependent suppression of CD4 T cell activation and proliferation by B cells activated through IgD cross-linking. Immunology, 144 (3), 444-452. (doi:10.1111/imm.12389).

Abstract

Although the co-stimulatory interaction between B and T cells is well defined, recent evidence suggests that B cells also have a regulatory role. Here, we show that B cells activated using anti-IgD conjugated to dextran (α-δ-dex) directly inhibit TCR-induced CD4 T cell activation, proliferation and cytokine production. This effect was observed in CD4 T cells activated both with and without CD28 co-stimulation. T cell viability was unaffected, and the T cell suppressive effect was mediated by contact with IgD activated purified B cells and not by IL-10 or other soluble factors. This is the first evidence of IgD activated B cells mediating inhibition of activation and proliferation of CD4 T cells in humans. This article is protected by copyright. All rights reserved.

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Contributors

Author: Robert C. Read

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