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Contact dependent suppression of CD4 T cell activation and proliferation by B cells activated through IgD cross-linking

Contact dependent suppression of CD4 T cell activation and proliferation by B cells activated through IgD cross-linking
Contact dependent suppression of CD4 T cell activation and proliferation by B cells activated through IgD cross-linking

Although the co-stimulatory interaction between B and T cells is well defined, recent evidence suggests that B cells also have a regulatory role. Here, we show that B cells activated using anti-IgD conjugated to dextran (α-δ-dex) directly inhibit TCR-induced CD4 T cell activation, proliferation and cytokine production. This effect was observed in CD4 T cells activated both with and without CD28 co-stimulation. T cell viability was unaffected, and the T cell suppressive effect was mediated by contact with IgD activated purified B cells and not by IL-10 or other soluble factors. This is the first evidence of IgD activated B cells mediating inhibition of activation and proliferation of CD4 T cells in humans. This article is protected by copyright. All rights reserved.

Journal Article
0019-2805
444-452
Preciado-Llanes, Lorena
122ac7cb-7e03-4736-b1c6-e05850db1cf7
Wing, James B.
f1e7db81-a229-4386-87ea-f58dd0e8519a
Foster, Rachel A.
ae78b2b5-6fee-486e-ac49-b755d2d2314c
Carlring, Jennifer
6d5de399-1da9-45e6-83ac-b7735f806348
Lees, Andrew
dba4db52-3b05-4414-a801-e3255d068b67
Read, Robert C.
b5caca7b-0063-438a-b703-7ecbb6fc2b51
Heath, Andrew W.
303a3623-9848-4b85-add7-880752386f0d
Preciado-Llanes, Lorena
122ac7cb-7e03-4736-b1c6-e05850db1cf7
Wing, James B.
f1e7db81-a229-4386-87ea-f58dd0e8519a
Foster, Rachel A.
ae78b2b5-6fee-486e-ac49-b755d2d2314c
Carlring, Jennifer
6d5de399-1da9-45e6-83ac-b7735f806348
Lees, Andrew
dba4db52-3b05-4414-a801-e3255d068b67
Read, Robert C.
b5caca7b-0063-438a-b703-7ecbb6fc2b51
Heath, Andrew W.
303a3623-9848-4b85-add7-880752386f0d

Preciado-Llanes, Lorena, Wing, James B., Foster, Rachel A., Carlring, Jennifer, Lees, Andrew, Read, Robert C. and Heath, Andrew W. (2015) Contact dependent suppression of CD4 T cell activation and proliferation by B cells activated through IgD cross-linking. Immunology, 144 (3), 444-452. (doi:10.1111/imm.12389).

Record type: Article

Abstract

Although the co-stimulatory interaction between B and T cells is well defined, recent evidence suggests that B cells also have a regulatory role. Here, we show that B cells activated using anti-IgD conjugated to dextran (α-δ-dex) directly inhibit TCR-induced CD4 T cell activation, proliferation and cytokine production. This effect was observed in CD4 T cells activated both with and without CD28 co-stimulation. T cell viability was unaffected, and the T cell suppressive effect was mediated by contact with IgD activated purified B cells and not by IL-10 or other soluble factors. This is the first evidence of IgD activated B cells mediating inhibition of activation and proliferation of CD4 T cells in humans. This article is protected by copyright. All rights reserved.

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More information

Accepted/In Press date: 20 September 2014
e-pub ahead of print date: 13 February 2015
Published date: March 2015
Additional Information: This article is protected by copyright. All rights reserved.
Keywords: Journal Article

Identifiers

Local EPrints ID: 417933
URI: https://eprints.soton.ac.uk/id/eprint/417933
ISSN: 0019-2805
PURE UUID: f133d032-c4de-4899-88d3-245e687d5c06
ORCID for Robert C. Read: ORCID iD orcid.org/0000-0002-4297-6728

Catalogue record

Date deposited: 16 Feb 2018 17:31
Last modified: 14 Mar 2019 01:36

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Contributors

Author: Lorena Preciado-Llanes
Author: James B. Wing
Author: Rachel A. Foster
Author: Jennifer Carlring
Author: Andrew Lees
Author: Robert C. Read ORCID iD
Author: Andrew W. Heath

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