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A sub-30 mpH resolution thin film transistor-based nanoribbon biosensing platform

A sub-30 mpH resolution thin film transistor-based nanoribbon biosensing platform
A sub-30 mpH resolution thin film transistor-based nanoribbon biosensing platform
We present a complete biosensing system that comprises a Thin Film Transistor (TFT)-based nanoribbon biosensor and a low noise, high-performance bioinstrumentation platform, capable of detecting sub-30 mpH unit changes, validated by an enzymatic biochemical reaction. The nanoribbon biosensor was fabricated top-down with an ultra-thin (15 nm) polysilicon semiconducting channel that offers excellent sensitivity to surface potential changes. The sensor is coupled to an integrated circuit (IC), which combines dual switched-capacitor integrators with high precision analog-to-digital converters (ADCs). Throughout this work, we employed both conventional pH buffer measurements as well as urea-urease enzymatic reactions for benchmarking the overall performance of the system. The measured results from the urea-urease reaction demonstrate that the system can detect urea in concentrations as low as 25 µM, which translates to a change of 27 mpH, according to our initial pH characterisation measurements. The attained accuracy and resolution of our system as well as its
low-cost manufacturability, high processing speed and portability make it a competitive solution for applications requiring rapid and accurate results at remote locations; a necessity for Point-of-Care (POC) diagnostic platforms.
analog-to-digital conversion, biosensor, nanoribbon, pH sensing, Point-of-Care diagnostics, switched capacitor, TFT, urea-urease reaction
1424-8220
1-12
Zeimpekis, Ioannis
a2c354ec-3891-497c-adac-89b3a5d96af0
Papadimitriou, Konstantinos
c0535540-f862-41b1-9cf3-92b1f46a4145
Sun, Kai
b7c648a3-7be8-4613-9d4d-1bf937fb487b
Hu, Chunxiao
4892b566-6809-42a8-8285-1c1e93aac730
Ashburn, Peter
68cef6b7-205b-47aa-9efb-f1f09f5c1038
Morgan, Hywel
de00d59f-a5a2-48c4-a99a-1d5dd7854174
Prodromakis, Themistoklis
d58c9c10-9d25-4d22-b155-06c8437acfbf
Zeimpekis, Ioannis
a2c354ec-3891-497c-adac-89b3a5d96af0
Papadimitriou, Konstantinos
c0535540-f862-41b1-9cf3-92b1f46a4145
Sun, Kai
b7c648a3-7be8-4613-9d4d-1bf937fb487b
Hu, Chunxiao
4892b566-6809-42a8-8285-1c1e93aac730
Ashburn, Peter
68cef6b7-205b-47aa-9efb-f1f09f5c1038
Morgan, Hywel
de00d59f-a5a2-48c4-a99a-1d5dd7854174
Prodromakis, Themistoklis
d58c9c10-9d25-4d22-b155-06c8437acfbf

Zeimpekis, Ioannis, Papadimitriou, Konstantinos, Sun, Kai, Hu, Chunxiao, Ashburn, Peter, Morgan, Hywel and Prodromakis, Themistoklis (2017) A sub-30 mpH resolution thin film transistor-based nanoribbon biosensing platform. Sensors, 17 (9), 1-12. (doi:10.3390/s17092000).

Record type: Article

Abstract

We present a complete biosensing system that comprises a Thin Film Transistor (TFT)-based nanoribbon biosensor and a low noise, high-performance bioinstrumentation platform, capable of detecting sub-30 mpH unit changes, validated by an enzymatic biochemical reaction. The nanoribbon biosensor was fabricated top-down with an ultra-thin (15 nm) polysilicon semiconducting channel that offers excellent sensitivity to surface potential changes. The sensor is coupled to an integrated circuit (IC), which combines dual switched-capacitor integrators with high precision analog-to-digital converters (ADCs). Throughout this work, we employed both conventional pH buffer measurements as well as urea-urease enzymatic reactions for benchmarking the overall performance of the system. The measured results from the urea-urease reaction demonstrate that the system can detect urea in concentrations as low as 25 µM, which translates to a change of 27 mpH, according to our initial pH characterisation measurements. The attained accuracy and resolution of our system as well as its
low-cost manufacturability, high processing speed and portability make it a competitive solution for applications requiring rapid and accurate results at remote locations; a necessity for Point-of-Care (POC) diagnostic platforms.

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More information

Accepted/In Press date: 28 August 2017
e-pub ahead of print date: 1 September 2017
Keywords: analog-to-digital conversion, biosensor, nanoribbon, pH sensing, Point-of-Care diagnostics, switched capacitor, TFT, urea-urease reaction

Identifiers

Local EPrints ID: 417953
URI: https://eprints.soton.ac.uk/id/eprint/417953
ISSN: 1424-8220
PURE UUID: 61e8bb18-3797-49ce-9925-bc9f13b29abc
ORCID for Hywel Morgan: ORCID iD orcid.org/0000-0003-4850-5676
ORCID for Themistoklis Prodromakis: ORCID iD orcid.org/0000-0002-6267-6909

Catalogue record

Date deposited: 19 Feb 2018 17:30
Last modified: 10 Sep 2019 00:45

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