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Statin use and knee osteoarthritis progression: Results from a post-hoc analysis of the SEKOIA trial

Statin use and knee osteoarthritis progression: Results from a post-hoc analysis of the SEKOIA trial
Statin use and knee osteoarthritis progression: Results from a post-hoc analysis of the SEKOIA trial
Objective Epidemiological and experimental studies have suggested that lipid disorders might be involved in the pathophysiology of knee osteoarthritis (OA). Studies assessing the effect of statins on knee OA progression have shown conflicting results. We investigated the impact of statin use on radiological progression in patients with radiological and symptomatic knee OA.Methods In total, 336 patients from the placebo arm of SEKOIA trial completed the 3-year follow-up and were included in this post-hoc analysis. Statin use was recorded at baseline interview. Minimal medial tibiofemoral joint space was measured on plain radiographs by an automated method at baseline and then annually. Radiologic progression was defined as joint space narrowing ≥ 0.5 mm over 3 years.Results Overall, 71 patients were statin users (21.1%). They had a higher BMI (31.1 ± 5.3 vs. 29.3 ± 5.2 kg/m2, P = 0.008), a higher sum of metabolic factors (≥ 3 factors: 43.7% vs 7.2%; P for trend < 0.001) and a higher rate of radiological progression (49.3% vs. 32.1%, P = 0.007) as compared to statin non-users. The significant association between radiological progression and statin use was independent of age, gender, WOMAC global score, disease duration, baseline joint space width, hypertension, type 2 diabetes, obesity (BMI > 30 kg/m2) and cardiovascular diseases [relative risk 1.49 (95% CI: 1.10–2.02), P = 0.010].Conclusion Among patients with knee OA, statin use was associated with radiological worsening over 3 years, regardless of other potential confounding factors (obesity, type 2 diabetes, hypertension, disease duration, symptom intensity and radiological severity).
1297-319X
609-614
Eymard, F.
2265cc6f-025b-48ef-b7d0-c939aa0860bd
Parsons, Camille
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Edwards, Mark
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Petit Dop, Florence
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Reginster, Jean-Yves
db56b103-184d-46e1-9600-f47f7a09a492
Bruyère, O.
855151e7-5d67-44ef-a7bd-b1d0898b432a
Chevalier, X.
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Cooper, Cyrus
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Richette, P.
81184c8f-3602-4bf4-93ca-dc720d42f6c1
Eymard, F.
2265cc6f-025b-48ef-b7d0-c939aa0860bd
Parsons, Camille
9730e5c3-0382-4ed7-8eaa-6932ab09ec15
Edwards, Mark
b81ff294-1d16-4a1b-af14-9374c5989d4c
Petit Dop, Florence
0af40637-efb0-4e14-a41f-9a6c9f891916
Reginster, Jean-Yves
db56b103-184d-46e1-9600-f47f7a09a492
Bruyère, O.
855151e7-5d67-44ef-a7bd-b1d0898b432a
Chevalier, X.
c1ff9aea-e2ee-4c00-a499-70d892d3c428
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Richette, P.
81184c8f-3602-4bf4-93ca-dc720d42f6c1

Eymard, F., Parsons, Camille, Edwards, Mark, Petit Dop, Florence, Reginster, Jean-Yves, Bruyère, O., Chevalier, X., Cooper, Cyrus and Richette, P. (2018) Statin use and knee osteoarthritis progression: Results from a post-hoc analysis of the SEKOIA trial. Joint Bone Spine, 85 (5), 609-614. (doi:10.1016/j.jbspin.2017.09.014).

Record type: Article

Abstract

Objective Epidemiological and experimental studies have suggested that lipid disorders might be involved in the pathophysiology of knee osteoarthritis (OA). Studies assessing the effect of statins on knee OA progression have shown conflicting results. We investigated the impact of statin use on radiological progression in patients with radiological and symptomatic knee OA.Methods In total, 336 patients from the placebo arm of SEKOIA trial completed the 3-year follow-up and were included in this post-hoc analysis. Statin use was recorded at baseline interview. Minimal medial tibiofemoral joint space was measured on plain radiographs by an automated method at baseline and then annually. Radiologic progression was defined as joint space narrowing ≥ 0.5 mm over 3 years.Results Overall, 71 patients were statin users (21.1%). They had a higher BMI (31.1 ± 5.3 vs. 29.3 ± 5.2 kg/m2, P = 0.008), a higher sum of metabolic factors (≥ 3 factors: 43.7% vs 7.2%; P for trend < 0.001) and a higher rate of radiological progression (49.3% vs. 32.1%, P = 0.007) as compared to statin non-users. The significant association between radiological progression and statin use was independent of age, gender, WOMAC global score, disease duration, baseline joint space width, hypertension, type 2 diabetes, obesity (BMI > 30 kg/m2) and cardiovascular diseases [relative risk 1.49 (95% CI: 1.10–2.02), P = 0.010].Conclusion Among patients with knee OA, statin use was associated with radiological worsening over 3 years, regardless of other potential confounding factors (obesity, type 2 diabetes, hypertension, disease duration, symptom intensity and radiological severity).

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Accepted/In Press date: 27 September 2017
e-pub ahead of print date: 14 November 2017
Published date: October 2018

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Local EPrints ID: 417973
URI: https://eprints.soton.ac.uk/id/eprint/417973
ISSN: 1297-319X
PURE UUID: 8fe39238-76a3-4991-89de-930d08b0760e
ORCID for Cyrus Cooper: ORCID iD orcid.org/0000-0003-3510-0709

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Date deposited: 19 Feb 2018 17:31
Last modified: 03 Dec 2019 05:44

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Contributors

Author: F. Eymard
Author: Camille Parsons
Author: Mark Edwards
Author: Florence Petit Dop
Author: Jean-Yves Reginster
Author: O. Bruyère
Author: X. Chevalier
Author: Cyrus Cooper ORCID iD
Author: P. Richette

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