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Immunotherapy for Pediatric Malignancies

Immunotherapy for Pediatric Malignancies
Immunotherapy for Pediatric Malignancies
This book provides a comprehensive overview of current immunotherapy strategies, and how these may be applicable to childhood cancers. The first part of the book reviews how the immune system recognizes cancer, and the various escape mechanisms allowing tumour growth. The importance of the tumor microenvironment and the challenges this may present to achieving effective immunotherapy are discussed. Monoclonal antibodies, cellular, cytokine and vaccine therapies are all comprehensively reviewed, with particular focus on their potential application to pediatric cancers. Practical aspects of delivering such therapies to children, likely toxicities and potential biomarkers are considered. Finally, consideration is given to how, in the longer term, such therapies may be combined with conventional therapies such as chemotherapy and radiotherapy.
Springer
Gray, Juliet C.
12d5e17c-97bb-4d6d-8fc4-3914b730ed42
Marabelle, Aurelien
ea40ca57-8883-4101-a7a4-7c2606a4d686
Gray, Juliet C.
12d5e17c-97bb-4d6d-8fc4-3914b730ed42
Marabelle, Aurelien
ea40ca57-8883-4101-a7a4-7c2606a4d686

Gray, Juliet C. and Marabelle, Aurelien (2018) Immunotherapy for Pediatric Malignancies , Springer, 297pp.

Record type: Book

Abstract

This book provides a comprehensive overview of current immunotherapy strategies, and how these may be applicable to childhood cancers. The first part of the book reviews how the immune system recognizes cancer, and the various escape mechanisms allowing tumour growth. The importance of the tumor microenvironment and the challenges this may present to achieving effective immunotherapy are discussed. Monoclonal antibodies, cellular, cytokine and vaccine therapies are all comprehensively reviewed, with particular focus on their potential application to pediatric cancers. Practical aspects of delivering such therapies to children, likely toxicities and potential biomarkers are considered. Finally, consideration is given to how, in the longer term, such therapies may be combined with conventional therapies such as chemotherapy and radiotherapy.

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Published date: 2018

Identifiers

Local EPrints ID: 418099
URI: https://eprints.soton.ac.uk/id/eprint/418099
PURE UUID: 33f190f5-89bd-4051-88c6-5a8809d84133

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Date deposited: 22 Feb 2018 17:30
Last modified: 13 Mar 2019 18:52

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Contributors

Author: Juliet C. Gray
Author: Aurelien Marabelle

University divisions

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