The versatility of the CD1 lipid antigen presentation pathway
The versatility of the CD1 lipid antigen presentation pathway
The family of non-classical MHC class-I like CD1 molecules has an emerging role in human disease. Group 1 CD1 includes CD1a, CD1b, and CD1c which function to display lipids on the cell surface of antigen presenting cells for direct recognition by T cells. The recent advent of CD1 tetramers and the identification of novel lipid ligands has contributed towards the increasing number of CD1 restricted T cell clones captured. These advances have helped to identify novel donor unrestricted and semi-invariant T cell populations in humans and new mechanisms of T cell recognition. However, while there is opportunity to design broadly acting lipids and harness the therapeutic potential of conserved T cells, knowledge of their role in health and disease is lacking. We briefly summarise the current evidence implicating group 1 CD1 molecules in infection, cancer and autoimmunity and show that although CD1 are not as diverse as MHC, recent discoveries highlight their versatility as they exhibit intricate mechanisms of antigen presentation.
CD1, lipids , T cells, mycolic acid, Mycobacterium tuberculosis, cholesteryl-esters
Chancellor, Andrew
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Gadola, S.D.
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Mansour, Salah
4aecba5a-8387-4f7b-b766-0a9c309ccb8b
Chancellor, Andrew
d4ccaa1c-5d43-4476-b19f-4e3f27465d38
Gadola, S.D.
11e97b92-d3bd-4e93-b006-90c4c47c57c1
Mansour, Salah
4aecba5a-8387-4f7b-b766-0a9c309ccb8b
Chancellor, Andrew, Gadola, S.D. and Mansour, Salah
(2018)
The versatility of the CD1 lipid antigen presentation pathway.
Immunology.
Abstract
The family of non-classical MHC class-I like CD1 molecules has an emerging role in human disease. Group 1 CD1 includes CD1a, CD1b, and CD1c which function to display lipids on the cell surface of antigen presenting cells for direct recognition by T cells. The recent advent of CD1 tetramers and the identification of novel lipid ligands has contributed towards the increasing number of CD1 restricted T cell clones captured. These advances have helped to identify novel donor unrestricted and semi-invariant T cell populations in humans and new mechanisms of T cell recognition. However, while there is opportunity to design broadly acting lipids and harness the therapeutic potential of conserved T cells, knowledge of their role in health and disease is lacking. We briefly summarise the current evidence implicating group 1 CD1 molecules in infection, cancer and autoimmunity and show that although CD1 are not as diverse as MHC, recent discoveries highlight their versatility as they exhibit intricate mechanisms of antigen presentation.
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CD1 review Chancellor et al Revision - Clean
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Accepted/In Press date: 14 February 2018
e-pub ahead of print date: 20 February 2018
Keywords:
CD1, lipids , T cells, mycolic acid, Mycobacterium tuberculosis, cholesteryl-esters
Identifiers
Local EPrints ID: 418178
URI: http://eprints.soton.ac.uk/id/eprint/418178
ISSN: 0019-2805
PURE UUID: 32740df0-f1f3-465f-8669-8f6589c9ec3a
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Date deposited: 23 Feb 2018 17:30
Last modified: 16 Mar 2024 06:15
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Author:
Andrew Chancellor
Author:
S.D. Gadola
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