Dynamic contrast enhanced CT in nodule characterization: How we review and report

Qureshi, Nagmi R., Shah, Andrew, Eaton, Rosemary J., Miles, Ken and Gilbert, Fiona J. , Sputnik Investigators (2016) Dynamic contrast enhanced CT in nodule characterization: How we review and report. Cancer imaging : the official publication of the International Cancer Imaging Society, 16 (1), 16. (doi:10.1186/s40644-016-0074-4).

Abstract

Incidental indeterminate solitary pulmonary nodules (SPN) that measure less than 3 cm in size are an increasingly common finding on computed tomography (CT) worldwide. Once identified there are a number of imaging strategies that can be performed to help with nodule characterization. These include interval CT, dynamic contrast enhanced computed tomography (DCE-CT), (18)F-fluorodeoxyglucose positron emission tomography-computed tomography ((18)F-FDG-PET-CT). To date the most cost effective and efficient non-invasive test or combination of tests for optimal nodule characterization has yet to be determined.DCE-CT is a functional test that involves the acquisition of a dynamic series of images of a nodule before and following the administration of intravenous iodinated contrast medium. This article provides an overview of the current indications and limitations of DCE- CT in nodule characterization and a systematic approach to how to perform, analyse and interpret a DCE-CT scan.

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