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Exosomal microRNAs (exomiRs): small molecules with a big role in cancer

Exosomal microRNAs (exomiRs): small molecules with a big role in cancer
Exosomal microRNAs (exomiRs): small molecules with a big role in cancer

Exosomes are secreted vesicles which can transmit molecular cargo between cells. Exosomal microRNAs (exomiRs) have drawn much attention in recent years because there is increasing evidence to suggest that loading of microRNAs into exosomes is not a random process. Preclinical studies have identified functional roles for exomiRs in influencing many hallmarks of cancer. Mechanisms underpinning their actions, such as exomiR receptors ("miRceptors"), are now becoming apparent. Even more exciting is the fact that exomiRs are highly suitable candidates for use as non-invasive biomarkers in an era of personalized cancer medicine.

Journal Article
0304-3835
228-235
Bhome, Rahul
d7b1e0d3-5925-460a-871d-5f52f69c649b
Del Vecchio, Filippo
df19608c-9cd6-4f4e-aaa5-8b1c29ca56ab
Lee, Gui-Han
563bd569-ef2e-44ec-b1ca-b11be716ff40
Bullock, Marc D
e060d2b2-5e6f-449b-b8ae-f411b5a396c2
Primrose, John N
d85f3b28-24c6-475f-955b-ec457a3f9185
Sayan, A Emre
d1dbbcad-9c53-47c1-8b7e-1b45cc56e077
Mirnezami, Alex H
b3c7aee7-46a4-404c-bfe3-f72388e0bc94
Bhome, Rahul
d7b1e0d3-5925-460a-871d-5f52f69c649b
Del Vecchio, Filippo
df19608c-9cd6-4f4e-aaa5-8b1c29ca56ab
Lee, Gui-Han
563bd569-ef2e-44ec-b1ca-b11be716ff40
Bullock, Marc D
e060d2b2-5e6f-449b-b8ae-f411b5a396c2
Primrose, John N
d85f3b28-24c6-475f-955b-ec457a3f9185
Sayan, A Emre
d1dbbcad-9c53-47c1-8b7e-1b45cc56e077
Mirnezami, Alex H
b3c7aee7-46a4-404c-bfe3-f72388e0bc94

Bhome, Rahul, Del Vecchio, Filippo, Lee, Gui-Han, Bullock, Marc D, Primrose, John N, Sayan, A Emre and Mirnezami, Alex H (2018) Exosomal microRNAs (exomiRs): small molecules with a big role in cancer. Cancer Letters, 420, 228-235. (doi:10.1016/j.canlet.2018.02.002).

Record type: Article

Abstract

Exosomes are secreted vesicles which can transmit molecular cargo between cells. Exosomal microRNAs (exomiRs) have drawn much attention in recent years because there is increasing evidence to suggest that loading of microRNAs into exosomes is not a random process. Preclinical studies have identified functional roles for exomiRs in influencing many hallmarks of cancer. Mechanisms underpinning their actions, such as exomiR receptors ("miRceptors"), are now becoming apparent. Even more exciting is the fact that exomiRs are highly suitable candidates for use as non-invasive biomarkers in an era of personalized cancer medicine.

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More information

Accepted/In Press date: 2 February 2018
e-pub ahead of print date: 7 February 2018
Published date: 28 April 2018
Additional Information: Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.
Keywords: Journal Article

Identifiers

Local EPrints ID: 418257
URI: https://eprints.soton.ac.uk/id/eprint/418257
ISSN: 0304-3835
PURE UUID: d315affe-0664-45cf-9641-9732cd176a66
ORCID for John N Primrose: ORCID iD orcid.org/0000-0002-2069-7605

Catalogue record

Date deposited: 26 Feb 2018 17:30
Last modified: 06 Jun 2018 13:06

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Contributors

Author: Rahul Bhome
Author: Filippo Del Vecchio
Author: Gui-Han Lee
Author: Marc D Bullock
Author: John N Primrose ORCID iD
Author: A Emre Sayan

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