Exosomal microRNAs (exomiRs): small molecules with a big role in cancer
Exosomal microRNAs (exomiRs): small molecules with a big role in cancer
Exosomes are secreted vesicles which can transmit molecular cargo between cells. Exosomal microRNAs (exomiRs) have drawn much attention in recent years because there is increasing evidence to suggest that loading of microRNAs into exosomes is not a random process. Preclinical studies have identified functional roles for exomiRs in influencing many hallmarks of cancer. Mechanisms underpinning their actions, such as exomiR receptors ("miRceptors"), are now becoming apparent. Even more exciting is the fact that exomiRs are highly suitable candidates for use as non-invasive biomarkers in an era of personalized cancer medicine.
Journal Article
228-235
Bhome, Rahul
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Del Vecchio, Filippo
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Lee, Gui-Han
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Bullock, Marc D
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Primrose, John N
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Sayan, A Emre
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Mirnezami, Alex H
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28 April 2018
Bhome, Rahul
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Del Vecchio, Filippo
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Lee, Gui-Han
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Bullock, Marc D
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Primrose, John N
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Sayan, A Emre
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Mirnezami, Alex H
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Bhome, Rahul, Del Vecchio, Filippo, Lee, Gui-Han, Bullock, Marc D, Primrose, John N, Sayan, A Emre and Mirnezami, Alex H
(2018)
Exosomal microRNAs (exomiRs): small molecules with a big role in cancer.
Cancer Letters, 420, .
(doi:10.1016/j.canlet.2018.02.002).
Abstract
Exosomes are secreted vesicles which can transmit molecular cargo between cells. Exosomal microRNAs (exomiRs) have drawn much attention in recent years because there is increasing evidence to suggest that loading of microRNAs into exosomes is not a random process. Preclinical studies have identified functional roles for exomiRs in influencing many hallmarks of cancer. Mechanisms underpinning their actions, such as exomiR receptors ("miRceptors"), are now becoming apparent. Even more exciting is the fact that exomiRs are highly suitable candidates for use as non-invasive biomarkers in an era of personalized cancer medicine.
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Exosomal microRNAs (exomiRs) Small molecules with a big role in cancer
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Accepted/In Press date: 2 February 2018
e-pub ahead of print date: 7 February 2018
Published date: 28 April 2018
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Journal Article
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Local EPrints ID: 418257
URI: http://eprints.soton.ac.uk/id/eprint/418257
ISSN: 0304-3835
PURE UUID: d315affe-0664-45cf-9641-9732cd176a66
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Date deposited: 26 Feb 2018 17:30
Last modified: 16 Mar 2024 04:14
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Author:
Filippo Del Vecchio
Author:
Gui-Han Lee
Author:
Marc D Bullock
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