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Compound optimal designs for percentile estimation in dose-response models with restricted design intervals

Record type: Conference or Workshop Item (Paper)

In dose-response studies, the dose range is often restricted due to ethics concerns over drug toxicity and/or efficacy, particularly when human subjects are involved. We present locally optimal designs for the estimation of several percentiles simultaneously on restricted as well as unrestricted design intervals. Our results hold true for most of the commonly applied link functions with respect to the model under consideration.

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Citation

Biedermann, Stefanie, Dette, Holger and Zhu, Wei, (2005) Compound optimal designs for percentile estimation in dose-response models with restricted design intervals Ermakov, S.M., Melas, V.B. and Pepelyshev, A.N. (eds.) In Proceedings of the 5th St. Petersburg Workshop on Simulation. St. Petersburg State University., pp. 143-148.

More information

Published date: July 2005
Venue - Dates: The Fifth Workshop on Simulation, 2005-07-01
Keywords: Dose-response model, link function, percentile estimation, compound optimal design, A-optimality
Organisations: Statistics

Identifiers

Local EPrints ID: 41828
URI: http://eprints.soton.ac.uk/id/eprint/41828
PURE UUID: a0dc3e57-29ee-4862-8dbc-5679a9f6a5ef

Catalogue record

Date deposited: 06 Oct 2006
Last modified: 17 Jul 2017 15:27

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Contributors

Author: Holger Dette
Author: Wei Zhu
Editor: S.M. Ermakov
Editor: V.B. Melas
Editor: A.N. Pepelyshev

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