Compound optimal designs for percentile estimation in dose-response models with restricted design intervals


Biedermann, Stefanie, Dette, Holger and Zhu, Wei, (2005) Compound optimal designs for percentile estimation in dose-response models with restricted design intervals Ermakov, S.M., Melas, V.B. and Pepelyshev, A.N. (eds.) In Proceedings of the 5th St. Petersburg Workshop on Simulation. St. Petersburg State University., pp. 143-148.

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Description/Abstract

In dose-response studies, the dose range is often restricted due to ethics concerns over drug toxicity and/or efficacy, particularly when human subjects are involved. We present locally optimal designs for the estimation of several percentiles simultaneously on restricted as well as unrestricted design intervals. Our results hold true for most of the commonly applied link functions with respect to the model under consideration.

Item Type: Conference or Workshop Item (Paper)
Venue - Dates: The Fifth Workshop on Simulation, 2005-07-01
Keywords: Dose-response model, link function, percentile estimation, compound optimal design, A-optimality
Subjects:
Organisations: Statistics
ePrint ID: 41828
Date :
Date Event
July 2005Published
Date Deposited: 06 Oct 2006
Last Modified: 16 Apr 2017 18:58
Further Information:Google Scholar
URI: http://eprints.soton.ac.uk/id/eprint/41828

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