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Experimental medicine approaches to drug development in anxiety disorders

Experimental medicine approaches to drug development in anxiety disorders
Experimental medicine approaches to drug development in anxiety disorders
Numerous pharmacological and psychological approaches are efficacious in patients with generalized anxiety disorder (GAD) and social anxiety disorder (SAD), though some patients do not respond to treatment and others relapse despite continuing with interventions that were initially beneficial. Other patients respond but stop treatment because of unwanted effects including sexual dysfunction, emotional blunting and weight gain. There is much need for novel interventions with greater overall effectiveness and enhanced acceptability when compared to current treatments, or with particular effectiveness in specific patient groups.

‘Experimental medicine’ studies conducted in healthy subjects provide a ‘proof-of-concept’ approach for determining whether to progress to pivotal efficacy studies, thereby potentially reducing delays in translating innovations into clinical practice. Examples of such studies include inhalation of air ‘enriched’ with 7.5% carbon dioxide, which mirrors the subjective, autonomic and cognitive features of GAD, and administration of testosterone or oxytocin, which respectively target the social avoidance and emotion processing biases of SAD.
experimental medicine, , translation, carbon dioxide inhalation, testosterone, oxytocin, pharmacotherapy, generalized anxiety disorder, social anxiety disorder
Elesevier
Baldwin, David Stewart
1beaa192-0ef1-4914-897a-3a49fc2ed15e
Ayman, Abou-Aisha
514d9775-8070-485f-b59d-84b4a23c0d56
Nomikos, George
Feltner, Doug
Baldwin, David Stewart
1beaa192-0ef1-4914-897a-3a49fc2ed15e
Ayman, Abou-Aisha
514d9775-8070-485f-b59d-84b4a23c0d56
Nomikos, George
Feltner, Doug

Baldwin, David Stewart and Ayman, Abou-Aisha (2018) Experimental medicine approaches to drug development in anxiety disorders. In, Nomikos, George and Feltner, Doug (eds.) Translational Medicine in CNS Drug Development. Elesevier. ,

Record type: Book Section

Abstract

Numerous pharmacological and psychological approaches are efficacious in patients with generalized anxiety disorder (GAD) and social anxiety disorder (SAD), though some patients do not respond to treatment and others relapse despite continuing with interventions that were initially beneficial. Other patients respond but stop treatment because of unwanted effects including sexual dysfunction, emotional blunting and weight gain. There is much need for novel interventions with greater overall effectiveness and enhanced acceptability when compared to current treatments, or with particular effectiveness in specific patient groups.

‘Experimental medicine’ studies conducted in healthy subjects provide a ‘proof-of-concept’ approach for determining whether to progress to pivotal efficacy studies, thereby potentially reducing delays in translating innovations into clinical practice. Examples of such studies include inhalation of air ‘enriched’ with 7.5% carbon dioxide, which mirrors the subjective, autonomic and cognitive features of GAD, and administration of testosterone or oxytocin, which respectively target the social avoidance and emotion processing biases of SAD.

Text Baldwin-AbouAisha-060218 - Accepted Manuscript
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Accepted/In Press date: 1 February 2018
Published date: 1 September 2018
Keywords: experimental medicine, , translation, carbon dioxide inhalation, testosterone, oxytocin, pharmacotherapy, generalized anxiety disorder, social anxiety disorder

Identifiers

Local EPrints ID: 418284
URI: https://eprints.soton.ac.uk/id/eprint/418284
PURE UUID: 86d8d6c7-a67a-4c1e-b236-a0c3ce3ee73a

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Date deposited: 27 Feb 2018 17:30
Last modified: 27 Feb 2018 17:30

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Contributors

Author: Abou-Aisha Ayman
Editor: George Nomikos
Editor: Doug Feltner

University divisions

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