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FVIIa-antithrombin levels in early and late preeclampsia

FVIIa-antithrombin levels in early and late preeclampsia
FVIIa-antithrombin levels in early and late preeclampsia
Background Preeclampsia (PE) is associated with a hypercoagulability state. According to the gestational age (GA) at the onset of the disease, PE has been classified as early (GA < 34 weeks) and late (GA ≥ 34 weeks). It has been admitted that early PE is associated with ischemic placental lesions, while in late PE an adequate or slightly impaired placentation occurs, which suggests that the two clinical forms have distinct etiology. Tissue factor (TF) binds and activates plasma factor VII triggering the coagulation. The inhibitor antithrombin (AT), along with tissue factor pathway inhibitor, acts as an inhibitor of the FVIIa-TF pathway. Once the TF-FVIIa complex is formed, the binding and transfer of FVIIa to AT is facilitated and FVIIa activity is inhibited. Objective: We evaluated the FVIIa-AT complex levels in pregnant women with early and late severe PE (sPE), in order to verify if this biomarker can be useful for discriminating the two forms of the disease. Methods We evaluated 26 pregnant with severe early PE and 19 pregnant with severe late PE. FVIIa-AT levels were measured by STACLOT® (Diagnostica Stago). Statistical analysis was done by Mann-Whitney test. Results: Increased FVIIa-AT levels were found in early sPE [148.4 pM (137.1)] compared to late sPE [95.9 pM (66.5)] (P = 0.046), which suggests a higher pro-coagulant state when PE onset occurs before 34 weeks of gestation. Conclusion: These pioneer data allow inferring the relevance of FVIIa-AT as a device for early sPE diagnosis. However, the clinical relevance of FVIIa-AT complex surely needs to be fully clarified.
0009-8981
67-69
Dusse, Luci Maria S.
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Godoi, Lara C.
a290b120-d348-45b2-aee4-3c38dc40040f
Alpoim, Patrıcia N.
d1255031-cdda-4bc0-bc70-b999aa024b7c
Gomes, Karina B.
3ecaac52-151b-4740-86f9-207378d7b243
Sousa, Lirlândia P.
c59126a9-9243-4a67-a40f-4f640b838c81
Perucci, Luiza O.
d11e9d86-f928-4132-a2c7-d8495794b056
Lwaleed, Bashir
e7c59131-82ad-4a14-a227-7370e91e3f21
Carvalho, Maria G.
b7495b77-148e-47f5-88f2-f613b58be29f
Dusse, Luci Maria S.
3f8aa691-06d7-4d37-81d3-12719e292769
Godoi, Lara C.
a290b120-d348-45b2-aee4-3c38dc40040f
Alpoim, Patrıcia N.
d1255031-cdda-4bc0-bc70-b999aa024b7c
Gomes, Karina B.
3ecaac52-151b-4740-86f9-207378d7b243
Sousa, Lirlândia P.
c59126a9-9243-4a67-a40f-4f640b838c81
Perucci, Luiza O.
d11e9d86-f928-4132-a2c7-d8495794b056
Lwaleed, Bashir
e7c59131-82ad-4a14-a227-7370e91e3f21
Carvalho, Maria G.
b7495b77-148e-47f5-88f2-f613b58be29f

Dusse, Luci Maria S., Godoi, Lara C., Alpoim, Patrıcia N., Gomes, Karina B., Sousa, Lirlândia P., Perucci, Luiza O., Lwaleed, Bashir and Carvalho, Maria G. (2017) FVIIa-antithrombin levels in early and late preeclampsia. Clinica Chimica Acta, 474, 67-69. (doi:10.1016/j.cca.2017.08.040).

Record type: Letter

Abstract

Background Preeclampsia (PE) is associated with a hypercoagulability state. According to the gestational age (GA) at the onset of the disease, PE has been classified as early (GA < 34 weeks) and late (GA ≥ 34 weeks). It has been admitted that early PE is associated with ischemic placental lesions, while in late PE an adequate or slightly impaired placentation occurs, which suggests that the two clinical forms have distinct etiology. Tissue factor (TF) binds and activates plasma factor VII triggering the coagulation. The inhibitor antithrombin (AT), along with tissue factor pathway inhibitor, acts as an inhibitor of the FVIIa-TF pathway. Once the TF-FVIIa complex is formed, the binding and transfer of FVIIa to AT is facilitated and FVIIa activity is inhibited. Objective: We evaluated the FVIIa-AT complex levels in pregnant women with early and late severe PE (sPE), in order to verify if this biomarker can be useful for discriminating the two forms of the disease. Methods We evaluated 26 pregnant with severe early PE and 19 pregnant with severe late PE. FVIIa-AT levels were measured by STACLOT® (Diagnostica Stago). Statistical analysis was done by Mann-Whitney test. Results: Increased FVIIa-AT levels were found in early sPE [148.4 pM (137.1)] compared to late sPE [95.9 pM (66.5)] (P = 0.046), which suggests a higher pro-coagulant state when PE onset occurs before 34 weeks of gestation. Conclusion: These pioneer data allow inferring the relevance of FVIIa-AT as a device for early sPE diagnosis. However, the clinical relevance of FVIIa-AT complex surely needs to be fully clarified.

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FVIIa-antithrombin levels - Clinica Chimica Acta - Letter - Version of Record
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Accepted/In Press date: 28 August 2017
e-pub ahead of print date: 6 September 2017
Published date: November 2017

Identifiers

Local EPrints ID: 418297
URI: http://eprints.soton.ac.uk/id/eprint/418297
ISSN: 0009-8981
PURE UUID: 0b145cee-c02c-44ef-86dc-a57135631631

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Date deposited: 27 Feb 2018 17:31
Last modified: 25 Nov 2021 22:31

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Contributors

Author: Luci Maria S. Dusse
Author: Lara C. Godoi
Author: Patrıcia N. Alpoim
Author: Karina B. Gomes
Author: Lirlândia P. Sousa
Author: Luiza O. Perucci
Author: Bashir Lwaleed
Author: Maria G. Carvalho

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