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Sleep in adults with ADHD: systematic review and meta-analysis of subjective and objective studies

Sleep in adults with ADHD: systematic review and meta-analysis of subjective and objective studies
Sleep in adults with ADHD: systematic review and meta-analysis of subjective and objective studies
Sleep alterations associated with adulthood ADHD are poorly understood. Here, we conducted the first meta-analysis of sleep studies in adults with ADHD. Based on a pre-registered protocol (PROSPERO-CRD42017065407), we searched Pubmed, Ovid and Web of Knowledge databases through August 3rd, 2017, with no language or publication type restrictions, and contacted study authors for unpublished data/information. From a pool of 8,812 references, we retained 13 studies. Random-effects models were performed and study quality was rated using the Newcastle-Ottawa Scale. Compared to adults without ADHD, those with ADHD significantly differed in seven out of nine subjective parameters (Standardized Mean Difference, SMD, ranging from 0.56 to 1.55) and two out of five actigraphic parameters [SMD (95% CI): sleep onset latency: 0.80 (0.46-1.14); sleep efficiency: -0.68 (-1.03, -0.34)]. No significant differences were detected for polysomnographic parameters. We conclude that, whereas subjectively reported sleep problems are significantly associated with ADHD in adults and should be systematically screened during the clinical interview, additional research is needed to understand if they are underpinned by objective sleep alterations.
0149-7634
Diaz Roman, Amparo
47ad1105-3105-4a04-a4d1-f17eb8a36596
Cortese, Samuele
53d4bf2c-4e0e-4c77-9385-218350560fdb
Mitchell, Raziya
e070a965-f581-4418-8b07-4b20a78fd793
Diaz Roman, Amparo
47ad1105-3105-4a04-a4d1-f17eb8a36596
Cortese, Samuele
53d4bf2c-4e0e-4c77-9385-218350560fdb
Mitchell, Raziya
e070a965-f581-4418-8b07-4b20a78fd793

Diaz Roman, Amparo, Cortese, Samuele and Mitchell, Raziya (2018) Sleep in adults with ADHD: systematic review and meta-analysis of subjective and objective studies. Neuroscience & Biobehavioral Reviews. (doi:10.1016/j.neubiorev.2018.02.014).

Record type: Article

Abstract

Sleep alterations associated with adulthood ADHD are poorly understood. Here, we conducted the first meta-analysis of sleep studies in adults with ADHD. Based on a pre-registered protocol (PROSPERO-CRD42017065407), we searched Pubmed, Ovid and Web of Knowledge databases through August 3rd, 2017, with no language or publication type restrictions, and contacted study authors for unpublished data/information. From a pool of 8,812 references, we retained 13 studies. Random-effects models were performed and study quality was rated using the Newcastle-Ottawa Scale. Compared to adults without ADHD, those with ADHD significantly differed in seven out of nine subjective parameters (Standardized Mean Difference, SMD, ranging from 0.56 to 1.55) and two out of five actigraphic parameters [SMD (95% CI): sleep onset latency: 0.80 (0.46-1.14); sleep efficiency: -0.68 (-1.03, -0.34)]. No significant differences were detected for polysomnographic parameters. We conclude that, whereas subjectively reported sleep problems are significantly associated with ADHD in adults and should be systematically screened during the clinical interview, additional research is needed to understand if they are underpinned by objective sleep alterations.

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Submitted date: 2 February 2018
Accepted/In Press date: 19 February 2018
e-pub ahead of print date: 2 March 2018

Identifiers

Local EPrints ID: 418332
URI: http://eprints.soton.ac.uk/id/eprint/418332
ISSN: 0149-7634
PURE UUID: fdaa3109-2561-492d-b96e-935159a7d4ff
ORCID for Samuele Cortese: ORCID iD orcid.org/0000-0001-5877-8075

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Date deposited: 28 Feb 2018 17:30
Last modified: 24 Oct 2020 04:02

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